scholarly journals Zebrafishfoggy/spt5is required for migration of facial branchiomotor neurons but not for their survival

2005 ◽  
Vol 234 (3) ◽  
pp. 651-658 ◽  
Author(s):  
Kimberly L. Cooper ◽  
Juli Armstrong ◽  
Cecilia B. Moens
Keyword(s):  
Facial Branchiomotor Neurons

scholarly journals Cadherin-2 Is Required Cell Autonomously for Collective Migration of Facial Branchiomotor Neurons

PLoS ONE ◽  
2016 ◽  
Vol 11 (10) ◽  
pp. e0164433 ◽  
Author(s):  
Jane K. Rebman ◽  
Kathryn E. Kirchoff ◽  
Gregory S. Walsh
Keyword(s):  
Collective Migration ◽  
Facial Branchiomotor Neurons

scholarly journals The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4

Development ◽  
1999 ◽  
Vol 126 (23) ◽  
pp. 5523-5531 ◽  
Author(s):  
I. Pata ◽  
M. Studer ◽  
J.H. van Doorninck ◽  
J. Briscoe ◽  
S. Kuuse ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Motor Neurons ◽  
Ectopic Expression ◽  
Downstream Effector ◽  
Gata3 Expression ◽  
Efferent Neurons ◽  
Facial Branchiomotor Neurons ◽  
Deficient Mice ◽  
Rhombomere 4

In this paper, we show that the transcription factor GATA3 is dynamically expressed during hindbrain development. Function of GATA3 in ventral rhombomere (r) 4 is dependent on functional GATA2, which in turn is under the control of Hoxb1. In particular, the absence of Hoxb1 results in the loss of GATA2 expression in r4 and the absence of GATA2 results in the loss of GATA3 expression. The lack of GATA3 expression in r4 inhibits the projection of contralateral vestibuloacoustic efferent neurons and the migration of facial branchiomotor neurons similar to Hoxb1-deficient mice. Ubiquitous expression of Hoxb1 in the hindbrain induces ectopic expression of GATA2 and GATA3 in ventral r2 and r3. These findings demonstrate that GATA2 and GATA3 lie downstream of Hoxb1 and provide the first example of Hox pathway transcription factors within a defined population of vertebrate motor neurons.

scholarly journals Dpysl2 (CRMP2) is required for the migration of facial branchiomotor neurons in the developing zebrafish embryo

2020 ◽  
Vol 64 (10-11-12) ◽  
pp. 479-484
Author(s):  
Carolina Fiallos-Oliveros ◽  
Toshio Ohshima
Keyword(s):  
Motor Neurons ◽  
System Development ◽  
Nervous System Development ◽  
Knock Out ◽  
Facial Branchiomotor Neurons ◽  
Morpholino Oligonucleotides ◽  
Mutant Phenotypes ◽  
Antisense Morpholino Oligonucleotides

Dihydropyrimidinase-like family proteins (Dpysls) are relevant in several processes during nervous system development; among others, they are involved in axonal growth and cell migration. Dpysl2 (CRMP2) is the most studied member of this family; however, its role in vivo is still being investigated. Our previous studies in zebrafish showed the requirement of Dpysl2 for the proper positioning of caudal primary motor neurons and Rohon-Beard neurons in the spinal cord.In the present study, we show that Dpysl2 is necessary for the proper migration of facial branchiomotor neurons during early development in zebrafish. We generated a dpysl2 knock-out (KO) zebrafish mutant line and used different types of antisense morpholino oligonucleotides (AMO) to analyze the role of Dpysl2 in this process. Both dpysl2 KO mutants and morphants exhibited abnormalities in the migration of these neurons from rhombomers (r) 4 and 5 to 6 and 7. The facial branchiomotor neurons that were expected to be at r6 were still located at r4 and r5 hours after the migration process should have been completed. In addition, mutant phenotypes were rescued by injecting dpysl2 mRNA into the KO embryos. These results indicate that Dpysl2 is involved in the proper migration of facial branchiomotor neurons in developing zebrafish embryos.

scholarly journals The atypical cadherin Celsr1 functions non-cell autonomously to block rostral migration of facial branchiomotor neurons in mice

2016 ◽  
Vol 417 (1) ◽  
pp. 40-49 ◽  
Author(s):  
Derrick M. Glasco ◽  
Whitney Pike ◽  
Yibo Qu ◽  
Lindsay Reustle ◽  
Kamana Misra ◽  
...  
Keyword(s):  
Facial Branchiomotor Neurons

scholarly journals Atypical Cadherins Celsr1-3 Differentially Regulate Migration of Facial Branchiomotor Neurons in Mice

2010 ◽  
Vol 30 (28) ◽  
pp. 9392-9401 ◽  
Author(s):  
Y. Qu ◽  
D. M. Glasco ◽  
L. Zhou ◽  
A. Sawant ◽  
A. Ravni ◽  
...  
Keyword(s):  
Facial Branchiomotor Neurons

scholarly journals The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled

2012 ◽  
Vol 369 (2) ◽  
pp. 211-222 ◽  
Author(s):  
Derrick M. Glasco ◽  
Vinoth Sittaramane ◽  
Whitney Bryant ◽  
Bernd Fritzsch ◽  
Anagha Sawant ◽  
...  
Keyword(s):  
Facial Branchiomotor Neurons

scholarly journals Prickle1 is necessary for the caudal migration of murine facial branchiomotor neurons

2014 ◽  
Vol 357 (3) ◽  
pp. 549-561 ◽  
Author(s):  
Tian Yang ◽  
Alexander G. Bassuk ◽  
Sigmar Stricker ◽  
Bernd Fritzsch
Keyword(s):  
Facial Branchiomotor Neurons

scholarly journals Rest represses maturation within migrating facial branchiomotor neurons

2015 ◽  
Vol 401 (2) ◽  
pp. 220-235 ◽  
Author(s):  
Crystal E. Love ◽  
Victoria E. Prince
Keyword(s):  
Facial Branchiomotor Neurons
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