Sonic hedgehog regulates proliferation of the retinal ciliary marginal zone in posthatch chicks

2005 ◽  
Vol 233 (1) ◽  
pp. 66-75 ◽  
Author(s):  
Ala Moshiri ◽  
Christopher R. McGuire ◽  
Thomas A. Reh
Keyword(s):  
Sonic Hedgehog ◽  
Marginal Zone ◽  
Ciliary Marginal Zone

scholarly journals Purinergic Signals Regulate Daily S-Phase Cell Activity in the Ciliary Marginal Zone of the Zebrafish Retina

2011 ◽  
Vol 26 (2) ◽  
pp. 107-117 ◽  
Author(s):  
Maria Jimena Ricatti ◽  
Ariadna Gabriela Battista ◽  
Maria Zorrilla Zubilete ◽  
Maria Paula Faillace
Keyword(s):  
Marginal Zone ◽  
Cell Activity ◽  
S Phase ◽  
Phase Cell ◽  
Ciliary Marginal Zone

scholarly journals The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue

Development ◽  
2016 ◽  
Vol 143 (7) ◽  
pp. 1099-1107 ◽  
Author(s):  
Yinan Wan ◽  
Alexandra D. Almeida ◽  
Steffen Rulands ◽  
Naima Chalour ◽  
Leila Muresan ◽  
...  
Keyword(s):  
Marginal Zone ◽  
Time Lapse ◽  
Ciliary Marginal Zone

Loss of adenomatous polyposis coli (apc) results in an expanded ciliary marginal zone in the zebrafish eye

2010 ◽  
Vol 239 (7) ◽  
pp. 2066-2077 ◽  
Author(s):  
W. Zac Stephens ◽  
Megan Senecal ◽  
Minhtu Nguyen ◽  
Tatjana Piotrowski
Keyword(s):  
Adenomatous Polyposis Coli ◽  
Marginal Zone ◽  
Adenomatous Polyposis ◽  
Polyposis Coli ◽  
Ciliary Marginal Zone

A comparative study of neurogenesis in the retinal ciliary marginal zone of homeothermic vertebrates

2002 ◽  
Vol 134 (1-2) ◽  
pp. 31-41 ◽  
Author(s):  
R Kubota ◽  
J.N Hokoc ◽  
A Moshiri ◽  
C McGuire ◽  
T.A Reh
Keyword(s):  
Comparative Study ◽  
Marginal Zone ◽  
Ciliary Marginal Zone

scholarly journals Her9/Hes4 is required for retinal photoreceptor development, maintenance, and survival

2019 ◽  
Author(s):  
Cagney E. Coomer ◽  
Stephen G. Wilson ◽  
Kayla F. Titialii-Torres ◽  
Jessica D. Bills ◽  
Laura A. Krueger ◽  
...  
Keyword(s):  
Marginal Zone ◽  
Rod Photoreceptor ◽  
Lineage Specification ◽  
Extrinsic Factors ◽  
Helix Loop Helix ◽  
Retinal Photoreceptor ◽  
Vertebrate Photoreceptor ◽  
Photoreceptor Development ◽  
Ciliary Marginal Zone

AbstractThe intrinsic and extrinsic factors that regulate vertebrate photoreceptor specification and differentiation are complex, and our understanding of all the players is far from complete. Her9, the zebrafish ortholog of human HES4, is a basic helix-loop-helix-orange (bHLH-O) transcriptional repressor that regulates neurogenesis in several developmental contexts. We have previously shown that her9 is upregulated during chronic rod photoreceptor degeneration and regeneration in adult zebrafish, but little is known about the role of her9 during retinal development. To better understand the function of Her9 in the retina, we generated zebrafish her9 CRISPR mutants. Her9 homozygous mutants displayed striking retinal phenotypes, including decreased numbers of rods and red/green cones, whereas blue and UV cones were relatively unaffected. The reduction in rods and red/green cones correlated with defects in photoreceptor subtype lineage specification. The remaining rods and double cones displayed abnormally truncated outer segments, and elevated levels of apoptosis. In addition to the photoreceptor defects, her9 mutants also possessed a reduced proliferative ciliary marginal zone, and decreased and disorganized Müller glia. Mutation of her9 was larval lethal, with no mutants surviving past 13 days post fertilization. Our results reveal a previously undescribed role for Her9/Hes4 in photoreceptor differentiation, maintenance, and survival.

scholarly journals Eye morphogenesis driven by epithelial flow into the optic cup facilitated by modulation of bone morphogenetic protein

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Stephan Heermann ◽  
Lucas Schütz ◽  
Steffen Lemke ◽  
Kerstin Krieglstein ◽  
Joachim Wittbrodt
Keyword(s):  
Marginal Zone ◽  
Eye Development ◽  
Optic Vesicle ◽  
Basal Surface ◽  
Morphogenetic Protein ◽  
Retinal Determination ◽  
Optic Cup ◽  
Morphological Transformations ◽  
Vertebrate Eye ◽  
Ciliary Marginal Zone

The hemispheric, bi-layered optic cup forms from an oval optic vesicle during early vertebrate eye development through major morphological transformations. The overall basal surface, facing the developing lens, is increasing, while, at the same time, the space basally occupied by individual cells is decreasing. This cannot be explained by the classical view of eye development. Using zebrafish (Danio rerio) as a model, we show that the lens-averted epithelium functions as a reservoir that contributes to the growing neuroretina through epithelial flow around the distal rims of the optic cup. We propose that this flow couples morphogenesis and retinal determination. Our 4D data indicate that future stem cells flow from their origin in the lens-averted domain of the optic vesicle to their destination in the ciliary marginal zone. BMP-mediated inhibition of the flow results in ectopic neuroretina in the RPE domain. Ultimately the ventral fissure fails to close resulting in coloboma.

scholarly journals Retinal stem cells modulate proliferative parameters to coordinate post-embryonic morphogenesis in the eye of fish

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Erika Tsingos ◽  
Burkhard Höckendorf ◽  
Thomas Sütterlin ◽  
Stephan Kirchmaier ◽  
Niels Grabe ◽  
...  
Keyword(s):  
Stem Cells ◽  
Progenitor Cell ◽  
Marginal Zone ◽  
Clonal Analysis ◽  
Agent Based ◽  
Pigmented Epithelium ◽  
Embryonic Morphogenesis ◽  
Tissue Specific Stem Cells ◽  
Ciliary Marginal Zone ◽  
Cell Division Timing

Combining clonal analysis with a computational agent based model, we investigate how tissue-specific stem cells for neural retina (NR) and retinal pigmented epithelium (RPE) of the teleost medaka (Oryzias latipes) coordinate their growth rates. NR cell division timing is less variable, consistent with an upstream role as growth inducer. RPE cells divide with greater variability, consistent with a downstream role responding to inductive signals. Strikingly, the arrangement of the retinal ciliary marginal zone niche results in a spatially biased random lineage loss, where stem- and progenitor cell domains emerge spontaneously. Further, our data indicate that NR cells orient division axes to regulate organ shape and retinal topology. We highlight an unappreciated mechanism for growth coordination, where one tissue integrates cues to synchronize growth of nearby tissues. This strategy may enable evolution to modulate cell proliferation parameters in one tissue to adapt whole-organ morphogenesis in a complex vertebrate organ.

The ciliary marginal zone (CMZ) in development and regeneration of the vertebrate eye

2013 ◽  
Vol 116 ◽  
pp. 199-204 ◽  
Author(s):  
Andy J. Fischer ◽  
Jennifer L. Bosse ◽  
Heithem M. El-Hodiri
Keyword(s):  
Marginal Zone ◽  
Vertebrate Eye ◽  
Ciliary Marginal Zone
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