Cell fate specification along the anterior-posterior axis of the intermediate mesoderm

2005 ◽  
Vol 232 (4) ◽  
pp. 901-914 ◽  
Author(s):  
Hila Barak ◽  
Lea Rosenfelder ◽  
Thomas M. Schultheiss ◽  
Ram Reshef
Keyword(s):  
Cell Fate ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Intermediate Mesoderm ◽  
Anterior Posterior ◽  
Anterior Posterior Axis

Distinct mitogenic and cell fate specification functions of wingless in different regions of the wing

Development ◽  
1996 ◽  
Vol 122 (6) ◽  
pp. 1781-1789 ◽  
Author(s):  
C.J. Neumann ◽  
S.M. Cohen
Keyword(s):  
Cell Fate ◽  
Imaginal Disc ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Hinge Loss ◽  
Local Reduction ◽  
Ectopic Activation ◽  
Growth Promoting ◽  
Local Cell ◽  
Anterior Posterior

Patterning and proliferation are coordinately controlled in the development of Drosophila imaginal discs. Localized expression of decapentaplegic (dpp) at the anterior-posterior and wingless (wg) at the dorsal-ventral compartment boundaries controls growth of the wing with respect to the A/P and D/V axes. The growth-promoting effects of these organizers are thought to be indirect, since growth is dispersed throughout the disc, and is not localized near the sources of wg or dpp. wg has also been implicated in proximal-distal patterning of the wing hinge. In this report, we present evidence that wg is principally required for local cell proliferation in the hinge. Loss of wg expression leads to a local reduction in cell division, resulting in the deletion of a distinct set of wing hinge structures. Ectopic activation of the wg pathway in cells of the wing hinge leads to overproliferation without repatterning, indicating that wg acts as a mitogen in this part of the disc. By contrast, overexpression of wg in the wing blade leads to repatterning and only secondarily to proliferation. These results suggest that the Wg signal elicits very different responses in different regions of the wing imaginal disc.

Sox proteins: regulators of cell fate specification and differentiation

Development ◽  
2013 ◽  
Vol 140 (20) ◽  
pp. 4129-4144 ◽  
Author(s):  
Y. Kamachi ◽  
H. Kondoh
Keyword(s):  
Cell Fate ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Sox Proteins

scholarly journals Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification

2003 ◽  
Vol 259 (1) ◽  
pp. 150-161 ◽  
Author(s):  
Jun Motoyama ◽  
Ljiljana Milenkovic ◽  
Mizuho Iwama ◽  
Yayoi Shikata ◽  
Matthew P. Scott ◽  
...  
Keyword(s):  
Cell Fate ◽  
Neural Cell ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Neural Cell Fate
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