scholarly journals Developmental expression and nutritional regulation of a zebrafish gene homologous to mammalian microsomal triglyceride transfer protein large subunit

2004 ◽  
Vol 232 (2) ◽  
pp. 506-518 ◽  
Author(s):  
Esther Marza ◽  
Christophe Barthe ◽  
Michèle André ◽  
Laure Villeneuve ◽  
Chantal Hélou ◽  
...  
Keyword(s):  
Large Subunit ◽  
Microsomal Triglyceride Transfer Protein ◽  
Developmental Expression ◽  
Nutritional Regulation ◽  
Transfer Protein

Human microsomal triglyceride transfer protein large subunit gene structure

Biochemistry ◽  
1994 ◽  
Vol 33 (31) ◽  
pp. 9057-9061 ◽  
Author(s):  
Daru Sharp ◽  
Beverly Ricci ◽  
Bernadette Kienzle ◽  
Marie C. M. Lin ◽  
John R. Wetterau
Keyword(s):  
Gene Structure ◽  
Large Subunit ◽  
Microsomal Triglyceride Transfer Protein ◽  
Subunit Gene ◽  
Transfer Protein

scholarly journals Regulation of MTP expression in developing swine

2002 ◽  
Vol 43 (8) ◽  
pp. 1303-1311 ◽  
Author(s):  
Song Lu ◽  
Mark Huffman ◽  
Ying Yao ◽  
Charles M. Mansbach ◽  
Xiangying Cheng ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Mrna Expression ◽  
Large Subunit ◽  
Microsomal Triglyceride Transfer Protein ◽  
Dietary Lipid ◽  
Developmental Expression ◽  
Mrna Levels ◽  
Hepatic Expression ◽  
Subunit Mrna

To define the developmental expression of microsomal triglyceride transfer protein (MTP) large subunit mRNA and protein, samples of small intestine and liver were collected from 40-day gestation fetal, 2-day-old newborn, 3-week-old suckling, and 2-month-old weanling swine. In fetal animals, MTP mRNA expression was high in intestine and liver. Postnatally, jejunal expression paralleled the intake of a high-fat breast milk diet and declined after weaning. Ileal expression was comparable with that of jejunum in 2-day-old animals, but declined to low levels afterward. Hepatic expression declined postnatally and remained low. MTP protein expression generally paralleled mRNA expression, except in fetal intestine in which no 97 kDa protein was detected. In 2-day-old piglets, a high-triacylglycerol diet increased jejunal and ileal MTP mRNA levels, as compared to a low-triacylglycerol diet. To test the roles of glucocorticoids and fatty acids in MTP regulation, a newborn swine enterocyte cell line (IPEC-1) was used. Except at day 2 of differentiation, dexamethasone did not influence MTP expression. Fatty acids either up-regulated or down-regulated MTP expression, depending on the specific fatty acid and duration of exposure.Although programmed genetic cues regulate MTP expression during development, clearly the amount and fatty acid composition of dietary lipid also play regulatory roles.

scholarly journals Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia

2000 ◽  
Vol 41 (8) ◽  
pp. 1199-1204 ◽  
Author(s):  
Ken Ohashi ◽  
Shun Ishibashi ◽  
Jun-ichi Osuga ◽  
Ryu-ichi Tozawa ◽  
Kenji Harada ◽  
...  
Keyword(s):  
Protein Gene ◽  
Microsomal Triglyceride Transfer Protein ◽  
Novel Mutations ◽  
Transfer Protein
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