scholarly journals Embryonic development of folate binding protein-1 (Folbp1) knockout mice: Effects of the chemical form, dose, and timing of maternal folate supplementation

2004 ◽  
Vol 231 (1) ◽  
pp. 221-231 ◽  
Author(s):  
Ofer Spiegelstein ◽  
Laura E. Mitchell ◽  
Michelle Y. Merriweather ◽  
Ned J. Wicker ◽  
Qiang Zhang ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Knockout Mice ◽  
Binding Protein ◽  
Chemical Form ◽  
Folate Supplementation ◽  
Folate Binding Protein

Arsenic-Induced Congenital Malformations in Genetically Susceptible Folate Binding Protein-2 Knockout Mice

2001 ◽  
Vol 177 (3) ◽  
pp. 238-246 ◽  
Author(s):  
Bogdan Wlodarczyk ◽  
Ofer Spiegelstein ◽  
Janée Gelineau-van Waes ◽  
Roseann L. Vorce ◽  
Xiufen Lu ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Congenital Malformations ◽  
Binding Protein ◽  
Folate Binding Protein

Valproate-induced neural tube defects in folate-binding protein-2 (Folbp2) knockout mice

2003 ◽  
Vol 67 (12) ◽  
pp. 974-978 ◽  
Author(s):  
Ofer Spiegelstein ◽  
Michelle Y. Merriweather ◽  
Ned J. Wicker ◽  
Richard H. Finnell
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Knockout Mice ◽  
Binding Protein ◽  
Folate Binding Protein

scholarly journals KH-type splicing regulatory protein is a new component of chromatoid body

Reproduction ◽  
2017 ◽  
Vol 154 (6) ◽  
pp. 723-733 ◽  
Author(s):  
Huijuan Zhang ◽  
Guishuan Wang ◽  
Lin Liu ◽  
Xiaolin Liang ◽  
Yu Lin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Germ Cell ◽  
Knockout Mice ◽  
Binding Protein ◽  
Regulatory Protein ◽  
Somatic Cells ◽  
Chromatoid Body ◽  
Mechanistic Insight ◽  
Insight Into

The chromatoid body (CB) is a specific cloud-like structure in the cytoplasm of haploid spermatids. Recent findings indicate that CB is identified as a male germ cell-specific RNA storage and processing center, but its function has remained elusive for decades. In somatic cells, KH-type splicing regulatory protein (KSRP) is involved in regulating gene expression and maturation of select microRNAs (miRNAs). However, the function of KSRP in spermatogenesis remains unclear. In this study, we showed that KSRP partly localizes in CB, as a component of CB. KSRP interacts with proteins (mouse VASA homolog (MVH), polyadenylate-binding protein 1 (PABP1) and polyadenylate-binding protein 2 (PABP2)), mRNAs (Tnp2 and Odf1) and microRNAs (microRNA-182) in mouse CB. Moreover, KSRP may regulate the integrity of CB via DDX5-miRNA-182 pathway. In addition, we found abnormal expressions of CB component in testes of Ksrp-knockout mice and of patients with hypospermatogenesis. Thus, our results provide mechanistic insight into the role of KSRP in spermatogenesis.

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