Skeletal and pigment cell defects in thelockjaw mutant reveal multiple roles for zebrafishtfap2a in neural crest development

2003 ◽  
Vol 229 (1) ◽  
pp. 87-98 ◽  
Author(s):  
Robert D. Knight ◽  
Yashar Javidan ◽  
Sarah Nelson ◽  
Tailin Zhang ◽  
Thomas Schilling
Keyword(s):  
Neural Crest ◽  
Pigment Cell ◽  
Multiple Roles ◽  
Neural Crest Development

scholarly journals Regulation of melanocyte development by ligand-dependent BMP signaling underlies oncogenic BMP signaling in melanoma

2019 ◽  
Author(s):  
Alec K. Gramann ◽  
Arvind M. Venkatesan ◽  
Melissa Guerin ◽  
Craig J. Ceol
Keyword(s):  
Neural Crest ◽  
Pigment Cell ◽  
Terminal Differentiation ◽  
Melanoma Cells ◽  
Cell Development ◽  
Bmp Signaling ◽  
Pigment Cells ◽  
Cell Type ◽  
Neural Crest Development ◽  
Direct Regulation

AbstractPreventing terminal differentiation is important in the development and progression of many cancers including melanoma. Recent identification of the BMP ligand GDF6 as a novel melanoma oncogene showed GDF6-activated BMP signaling suppresses differentiation of melanoma cells. Previous studies have identified roles for GDF6 orthologs during early embryonic and neural crest development, but have not identified direct regulation of melanocyte development by GDF6. Here, we investigate the BMP ligand gdf6a, a zebrafish ortholog of human GDF6, during the development of melanocytes from the neural crest. We establish that the loss of gdf6a or inhibition of BMP signaling during neural crest development disrupts normal pigment cell development, leading to an increase in the number of melanocytes and a corresponding decrease in iridophores, another neural crest-derived pigment cell type in zebrafish. This shift occurs as pigment cells arise from the neural crest and depends on mitfa, an ortholog of MITF, a key regulator of melanocyte development that is also targeted by oncogenic BMP signaling. Together, these results indicate that the oncogenic role ligand-dependent BMP signaling plays in suppressing differentiation in melanoma is a reiteration of its physiological roles during melanocyte development.

scholarly journals Multiple roles of Sox2, an HMG-box transcription factor in avian neural crest development

2003 ◽  
Vol 229 (1) ◽  
pp. 74-86 ◽  
Author(s):  
Yoshio Wakamatsu ◽  
Yukinori Endo ◽  
Noriko Osumi ◽  
James A. Weston
Keyword(s):  
Transcription Factor ◽  
Neural Crest ◽  
Multiple Roles ◽  
Hmg Box ◽  
Neural Crest Development

scholarly journals Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Alec K Gramann ◽  
Arvind M Venkatesan ◽  
Melissa Guerin ◽  
Craig J Ceol
Keyword(s):  
Neural Crest ◽  
Pigment Cell ◽  
Terminal Differentiation ◽  
Melanoma Cells ◽  
Cell Development ◽  
Bmp Signaling ◽  
Pigment Cells ◽  
Cell Type ◽  
Neural Crest Development ◽  
Direct Regulation

Preventing terminal differentiation is important in the development and progression of many cancers including melanoma. Recent identification of the BMP ligand GDF6 as a novel melanoma oncogene showed GDF6-activated BMP signaling suppresses differentiation of melanoma cells. Previous studies have identified roles for GDF6 orthologs during early embryonic and neural crest development, but have not identified direct regulation of melanocyte development by GDF6. Here, we investigate the BMP ligand gdf6a, a zebrafish ortholog of human GDF6, during the development of melanocytes from the neural crest. We establish that the loss of gdf6a or inhibition of BMP signaling during neural crest development disrupts normal pigment cell development, leading to an increase in the number of melanocytes and a corresponding decrease in iridophores, another neural crest-derived pigment cell type in zebrafish. This shift occurs as pigment cells arise from the neural crest and depends on mitfa, an ortholog of MITF, a key regulator of melanocyte development that is also targeted by oncogenic BMP signaling. Together, these results indicate that the oncogenic role ligand-dependent BMP signaling plays in suppressing differentiation in melanoma is a reiteration of its physiological roles during melanocyte development.

Zebrafish pigmentation mutations and the processes of neural crest development

Development ◽  
1996 ◽  
Vol 123 (1) ◽  
pp. 369-389 ◽  
Author(s):  
R.N. Kelsh ◽  
M. Brand ◽  
Y.J. Jiang ◽  
C.P. Heisenberg ◽  
S. Lin ◽  
...  
Keyword(s):  
Neural Crest ◽  
Cell Fate ◽  
Large Scale ◽  
Pigment Cell ◽  
Cell Fate Specification ◽  
Cell Specification ◽  
Pigment Pattern ◽  
Mutagenesis Screen ◽  
Neural Crest Development

Neural crest development involves cell-fate specification, proliferation, patterned cell migration, survival and differentiation. Zebrafish neural crest derivatives include three distinct chromatophores, which are well-suited to genetic analysis of their development. As part of a large-scale mutagenesis screen for embryonic/early larval mutations, we have isolated 285 mutations affecting all aspects of zebrafish larval pigmentation. By complementation analysis, we define 94 genes. We show here that comparison of their phenotypes permits classification of these mutations according to the types of defects they cause, and these suggest which process of neural crest development is probably affected. Mutations in eight genes affect the number of chromatophores: these include strong candidates for genes necessary for the processes of pigment cell specification and proliferation. Mutations in five genes remove part of the wild-type pigment pattern, and suggest a role in larval pigment pattern formation. Mutations in five genes show ectopic chromatophores in distinct sites, and may have implications for chromatophore patterning and proliferation. 76 genes affect pigment or morphology of one or more chromatophore types: these mutations include strong candidates for genes important in various aspects of chromatophore differentiation and survival. In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development.

scholarly journals The methyltransferase NSD3 regulates neural crest development

2011 ◽  
Vol 356 (1) ◽  
pp. 196
Author(s):  
Bridget Jacques-Fricke ◽  
Laura S. Gammill
Keyword(s):  
Neural Crest ◽  
Neural Crest Development

Zika virus induces abnormal cranial osteogenesis by negatively affecting cranial neural crest development

2019 ◽  
Vol 69 ◽  
pp. 176-189 ◽  
Author(s):  
Yuqi Yan ◽  
Xiao-tan Zhang ◽  
Guang Wang ◽  
Xin Cheng ◽  
Yu Yan ◽  
...  
Keyword(s):  
Neural Crest ◽  
Zika Virus ◽  
Cranial Neural Crest ◽  
Neural Crest Development

scholarly journals Xenopus Nkx6.3 Is a Neural Plate Border Specifier Required for Neural Crest Development

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e115165 ◽  
Author(s):  
Zuming Zhang ◽  
Yu Shi ◽  
Shuhua Zhao ◽  
Jiejing Li ◽  
Chaocui Li ◽  
...  
Keyword(s):  
Neural Crest ◽  
Neural Plate ◽  
Neural Crest Development ◽  
Neural Plate Border
Sign in / Sign up

Export Citation Format

Share Document