scholarly journals Zygotic control of maternal cyclin A1 translation and mRNA stability

2002 ◽  
Vol 225 (4) ◽  
pp. 511-521 ◽  
Author(s):  
Yann Audic ◽  
Mark Garbrecht ◽  
Brian Fritz ◽  
Michael D. Sheets ◽  
Rebecca S. Hartley
Keyword(s):  
Mrna Stability ◽  
Cyclin A1 ◽  
Zygotic Control

scholarly journals Zygotic Regulation of Maternal Cyclin A1 and B2 mRNAs

2001 ◽  
Vol 21 (5) ◽  
pp. 1662-1671 ◽  
Author(s):  
Yann Audic ◽  
Christina Anderson ◽  
Robert Bhatty ◽  
Rebecca S. Hartley
Keyword(s):  
Cell Cycle ◽  
Embryonic Cell ◽  
Untranslated Regions ◽  
Specific Mechanism ◽  
Cyclin A1 ◽  
Midblastula Transition ◽  
Zygotic Transcription ◽  
Adult Cell ◽  
Embryonic Cell Cycle ◽  
Zygotic Control

ABSTRACT At the midblastula transition, the Xenopus laevis embryonic cell cycle is remodeled from rapid alternations between S and M phases to become the complex adult cell cycle. Cell cycle remodeling occurs after zygotic transcription initiates and is accompanied by terminal downregulation of maternal cyclins A1 and B2. We report here that the disappearance of both cyclin A1 and B2 proteins is preceded by the rapid deadenylation of their mRNAs. A specific mechanism triggers this deadenylation. This mechanism depends upon discrete regions of the 3′ untranslated regions and requires zygotic transcription. Together, these results strongly suggest that zygote-dependent deadenylation of cyclin A1 and cyclin B2 mRNAs is responsible for the downregulation of these proteins. These studies also raise the possibility that zygotic control of maternal cyclins plays a role in establishing the adult cell cycle.

scholarly journals Plakophilins 1 and 3 Bind to FXR1 and Thereby Influence the mRNA Stability of Desmosomal Proteins

2014 ◽  
Vol 34 (23) ◽  
pp. 4244-4256 ◽  
Author(s):  
R. Fischer-Ke o ◽  
S. Breuninger ◽  
S. Hofmann ◽  
M. Henn ◽  
T. Rohrig ◽  
...  
Keyword(s):  
Mrna Stability
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