Hydromorphone and codeine concentrations in oral fluid specimens from patients receiving substitution therapy with Substitol™ (morphine sulphate)

2021 ◽  
Author(s):  
Stefan Lierheimer ◽  
Olof Beck ◽  
Thomas Keller ◽  
Fabio Carlo Monticelli ◽  
Michael Böttcher
Keyword(s):  
Oral Fluid ◽  
Morphine Sulphate ◽  
Substitution Therapy

scholarly journals Direct Injection LC–MS-MS Analysis of Opiates, Methamphetamine, Buprenorphine, Methadone and Their Metabolites in Oral Fluid from Substitution Therapy Patients

2015 ◽  
Vol 39 (6) ◽  
pp. 472-480 ◽  
Author(s):  
Hsiu-Chuan Liu ◽  
Hsi-Tzu Lee ◽  
Ya-Ching Hsu ◽  
Mei-Han Huang ◽  
Ray H. Liu ◽  
...  
Keyword(s):  
Oral Fluid ◽  
Direct Injection ◽  
Substitution Therapy ◽  
Ms Analysis

P-10-3 Morphine-sulphate — an alternative in opiate substitution therapy

1995 ◽  
Vol 5 (3) ◽  
pp. 393
Author(s):  
C. Schneider ◽  
G. Fischer ◽  
K. Diamant ◽  
L. Pezawas ◽  
E. Lenzinger ◽  
...  
Keyword(s):  
Morphine Sulphate ◽  
Substitution Therapy ◽  
Opiate Substitution Therapy

Oral fluid as an alternative matrix for Therapeutic Drug Monitoring

2017 ◽  
Author(s):  
H Clement ◽  
J Preiskorn ◽  
S Studer ◽  
K Ebert ◽  
E Maurice ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Oral Fluid ◽  
Therapeutic Drug

ÜBER DIE BILDUNG VON ENDOMETRIALEN KÖRNCHENZELLEN BEI KASTRATINNEN UNTER HORMONEINFLUSS

1960 ◽  
Vol XXXIII (II) ◽  
pp. 261-276 ◽  
Author(s):  
G. Hellweg ◽  
J. Ferin ◽  
K. G. Ober
Keyword(s):  
Hormone Therapy ◽  
Stromal Cells ◽  
Sex Hormone ◽  
Substitution Therapy ◽  
Secretory Phase ◽  
Hormone Substitution ◽  
Endometrial Stromal Cells ◽  
Endometrial Stroma ◽  
K Cells

ABSTRACT 65 endometrial biopsies from castrated women who had received either natural or artificial sex hormone therapy were studied microscopically. Attention was paid to various histologic criteria, especially to the number of endometrial granulocytes (»K« cells, KZ). The following was obtained: The »K« cells are completely absent when no hormone substitution therapy is given. They were also lacking when the castrated patients were treated only with oestrogens, even if the dose given was ten-times that found in women during the reproductive ages. In contrast, the »K« cells developed from the endometrial stromal cells only under influence of progesterone, usually appearing first 8–10 days after the administration of the gestagen. The »K« cells were demonstrable in the number corresponding to a normal secretory phase only then, when the oestrogen-progesterone dosage ratio had induced a fully-developed secretory change, as measured by the usual histologic criteria. With an overdosage of oestrogen the »K« cells were either absent or were very sparse. Contrarily, an overdosage of progesterone had no influence on their number. The development of endometrial glands does not always entirely parallel that of the stroma in castrated patients following hormone therapy. A more exact indicator for the proper dose for the production of a secretory phase by hormone therapy seems to be the number of »K« cells in the endometrial stroma.

Substitution therapy for tear film deficiency

2018 ◽  
Vol 3 (32) ◽  
pp. 30
Author(s):  
Jaqueline Mocanu
Keyword(s):  
Tear Film ◽  
Substitution Therapy

INFLUENCE OF OFFICE BLEACHING SYSTEMS ON THE RESISTANCE OF HARD TOOTH TISSUES

2020 ◽  
pp. 119-125
Author(s):  
Magsumova O.A. ◽  
Postnikov M.A. ◽  
Ryskina E.A. ◽  
Tkach T.M. ◽  
Polkanova V.A.
Keyword(s):  
Informed Consent ◽  
Oral Fluid ◽  
Personal Data ◽  
Acid Resistance ◽  
Non Invasive ◽  
Hard Tissues ◽  
Voluntary Informed Consent

One of the non-invasive methods for treating discoloration of hard tooth tissues is teeth whitening. The aim of this work is to assess the dynamics of changes in the acid resistance of enamel and hard tissues of teeth and the rate of its remineralization after the procedure of office teeth whitening. The study involved 123 patients aged 18 to 35 years with discoloration of various origins, with the color of hard tooth tissues on the Vita Classic A2 scale and darker. Before performing the office, teeth whitening procedure, all patients gave their written voluntary informed consent to participate in this study, as well as consent to the processing of personal data. Depending on the chosen method of office teeth whitening, patients were divided into 3 groups. The resistance of hard tooth tissues was judged based on the determination of TOER and CASRE tests. These indicators were determined at various times (5 days before the office teeth whitening procedure, 5 days after it, after 14, 30 days and 6 months). Regardless of the chosen whitening system, the office teeth whitening procedure is accompanied by a decrease in the enamel's resistance to acids and a decrease in the rate of its remineralization. The remineralizing function of oral fluid promotes the positive dynamics of the studied parameters after 14 days and after 30 days values increased due to the appointment of remineralizing therapy to all patients in 2 weeks after the teeth whitening procedure. After 6 months, all patients had high enamel resistance and the rate of its remineralization.

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