Simultaneous spectrophotometric determination of paracetamol and para-aminophenol in pharmaceutical dosage forms using two novel multivariate standard addition methods based on net analyte signal and rank annihilation factor analysis

2011 ◽  
Vol 4 (6) ◽  
pp. 507-514 ◽  
Author(s):  
Saeed Yousefinejad ◽  
Bahram Hemmateenejad
Keyword(s):  
Factor Analysis ◽  
Spectrophotometric Determination ◽  
Standard Addition ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms ◽  
Net Analyte Signal ◽  
Analyte Signal

Generalized Net Analyte Signal Standard Addition as a Novel Method for Simultaneous Determination: Application in Spectrophotometric Determination of Some Pesticides

2014 ◽  
Vol 97 (1) ◽  
pp. 252-258 ◽  
Author(s):  
Karim Asadpour-Zeynali ◽  
Elhameh Saeb ◽  
Javad Vallipour ◽  
Mehdi Bamorowat
Keyword(s):  
Spectrophotometric Determination ◽  
Standard Addition ◽  
Standard Addition Method ◽  
Addition Method ◽  
Net Analyte Signal ◽  
Analyte Signal ◽  
Novel Method ◽  
Single Standard ◽  
Generalized Net

Abstract Simultaneous spectrophotometric determination of three neonicotinoid insecticides (acetamiprid,imidacloprid, and thiamethoxam) by a novel methodnamed generalized net analyte signal standard addition method (GNASSAM) in some binary and ternarysynthetic mixtures was investigated. For this purpose, standard addition was performed using a single standard solution consisting of a mixture ofstandards of all analytes. Savings in time and amount of used materials are some of the advantages of this method. All determinations showed appropriate applicability of this method with less than 5% error. This method may be applied for linearlydependent data in the presence of known interferents. The GNASSAM combines the advantages of both the generalized standard addition method and net analyte signal; therefore, it may be a properalternative for some other multivariate methods.

scholarly journals Use of N, N-diethyl-p-phenylenediamine sulphate for the spectrophotometric determination of some phenolic and amine drugs

2010 ◽  
Vol 60 (2) ◽  
pp. 217-227 ◽  
Author(s):  
Padmarajaiah Nagaraja ◽  
Ashwinee Shrestha ◽  
Anantharaman Shivakumar ◽  
Avinash Gowda
Keyword(s):  
Spectrophotometric Determination ◽  
Correlation Coefficients ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms ◽  
Variable Parameters ◽  
Spectrophotometric Methods ◽  
Linear Relationships ◽  
Colored Product ◽  
And Performance

Use ofN, N-diethyl-p-phenylenediamine sulphate for the spectrophotometric determination of some phenolic and amine drugsSpectrophotometric methods are proposed for the determination of drugs containing a phenol group [salbutamol sulphate (SLB), ritodrine hydrochloride (RTD), isoxsuprine hydrochloride (IXP)] and drugs containing an aromatic amine group [dapsone hydrochloride (DAP), sulfamethoxazole (SFM), and sulfadiazine (SFD)] in pharmaceutical dosage forms. The methods are based on coupling ofN, N-diethyl-p-phenylenediamine sulphate with the drugs in the presence of KIO4to give a green colored product (λmaxat 670 nm) and a red colored product (λmaxat 550 nm), respectively. Linear relationships with good correlation coefficients (0.9986-0.9996) were found between absorbance and the corresponding concentration of drugs in the range 1-7, 2-22, 1-17, 1.5-12, 2-25, and 2-21 μg mL-1for SLB, RTD, IXP, DAP, SFM and SFD, respectively. Variable parameters such as temperature, reaction time and concentration of the reactants have been analyzed and optimized. The RSD of intra-day and inter-day studies was in the range of 0.2-1.0 and 0.4-1.0%, respectively. No interference was observed from common pharmaceutical adjuvants. The reliability and performance of the proposed methods was validated statistically; the percentage recovery ranged from 99.5 ± 0.1 to 99.9 ± 0.3%. Limits of detection were 0.14, 0.21, 0.51, 0.44, 0.33 and 0.37 μg mL-1for SLB, RTD, IXP, DAP, SFM, and SFD, respectively.

Spectrophotometric determination of amodiaquine hydrochloride in pharmaceutical dosage forms

The Analyst ◽  
1982 ◽  
Vol 107 (1276) ◽  
pp. 776 ◽  
Author(s):  
G. Ramana Rao ◽  
Y. Pulla Rao ◽  
I. R. K. Raju
Keyword(s):  
Spectrophotometric Determination ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms

scholarly journals SPECTROMETRIC INVESTIGATION OF CEFPROZIL IN BULK POWDER AND IN PHARMACEUTICAL FORMULATIONS

2002 ◽  
Vol 70 (1) ◽  
pp. 67-76 ◽  
Author(s):  
EI-Adl Sobhy M. ◽  
Saleh Hanaa M.
Keyword(s):  
Metal Ion ◽  
Hydrolysis Product ◽  
Reference Method ◽  
Standard Addition ◽  
Pharmaceutical Formulations ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms ◽  
Bulk Powder ◽  
Ion Contents

Three accurate methods were developed for the quantitative determination of cefprozil in pure form and in its dosage forms. The first method was based upon the interaction of the drug with 3-methyl-benzothiazolinone-2-hydrazone (MBTH) in the presence of ceric ammonium sulfate or ferric chloride as an oxidizing agent, where the formed color was measured at λ 521 nm or 624 nm, respectively. The second inethod was based on the chelate formation with palladium (II) chloride (PdCl2) in the presence of buffered medium, where the formed complex was determined at λ 345 nm. The third method was based upon the reaction of the neutral solution of the hydrolysis product of drug with each of silver nitrate & lead acetate standard solutions, forming drug-metal complex and the metal ion contents were determined directly or indirectly by atomic absorption spectroscopy (AAS). The reaction conditions of the proposed methods were studied and optimized. The precision of the proposed methods was achieved by determining different samples of bulk powder and pharmaceutical dosage forms. The validity of the methods was assessed by applying the standard addition technique and the results were compared with those obtained by the reference method showing a great agreement

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