Determination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP-1, GHRP-2, GHRP-6, Hexarelin, and Ipamorelin

2015 ◽  
Vol 7 (10) ◽  
pp. 919-925 ◽  
Author(s):  
Ekaterina Semenistaya ◽  
Irina Zvereva ◽  
Andreas Thomas ◽  
Mario Thevis ◽  
Grigory Krotov ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Urine ◽  
Nasal Administration ◽  
Growth Hormone Releasing Peptides

IMMUNOREACTIVE GROWTH HORMONE IN HUMAN URINE

1972 ◽  
Vol 71 (4) ◽  
pp. 665-676 ◽  
Author(s):  
Kristian F. Hanssen
Keyword(s):  
Molecular Weight ◽  
Growth Hormone ◽  
Linear Relationship ◽  
Human Urine ◽  
Gel Filtration ◽  
Human Growth ◽  
Normal Subjects ◽  
Normal Human ◽  
Radio Immunoassay

ABSTRACT By using a double antibody radio-immunoassay (pre-precipitation technique) for the determination of immunoreactive human growth hormone (IRHGH) in normal human urine concentrated by dialysis and lyophilization, a factor was revealed that displaces 125I-HGH from HGH antibodies. This displacement was neither due to salts nor to glucose; it is suggested that it is due to IRHGH in the urine. A linear relationship between dilution of urine and the measured IRHGH concentration was obtained. Recovery of exogenous HGH was between 70–105%. The recovery of IRHGH from different volumes of urine following dialysis and lyophilization was between 97–110%. Plasma IRHGH and urinary IRHGH was measured simultaneously after HGH injection in a normal subject. A correlation was shown between plasma IRHGH and urinary IRHGH. In 9 normal subjects, the urinary IRHGH ranged from 28–53 ng/24 h. The excretion of urinary IRHGH was increased in acromegaly and was diminished in some, but not in all patients with adult hypopituitarism. The urinary IRHGH was further studied by gel filtration. It was recovered in one peak corresponding to a molecular weight of approximately 20 000 – 30 000. However, in the present work it was not clarified whether the urinary IRHGH represents pituitary HGH excreted in the urine or a metabolite of high molecular weight with retained immunological properties.

scholarly journals UHPLC-HRMS determination of some human growth hormone-releasing peptides in urine

2019 ◽  
Vol 23 (4) ◽  
pp. 509-516
Author(s):  
A. Z. Temerdashev ◽  
◽  
E. V. Dmitrieva ◽  
A. A. Azaryan ◽  
D. A. Burmikin ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Growth Hormone Releasing Peptides

scholarly journals LC-MS/MS Method for Simultaneous Analysis of Growth Hormone-Releasing Peptides and Secretagogues in Human Urine

2016 ◽  
Vol 7 (3) ◽  
pp. 55-63 ◽  
Author(s):  
Hophil Min ◽  
Boyoung Han ◽  
Changmin Sung ◽  
Ju-Hyung Park ◽  
Kang Mi Lee ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Urine ◽  
Simultaneous Analysis ◽  
Growth Hormone Releasing Peptides

Determination of therapeutics with growth-hormone secretagogue activity in human urine for doping control purposes

2006 ◽  
Vol 20 (22) ◽  
pp. 3393-3402 ◽  
Author(s):  
Mario Thevis ◽  
Frauke Wilkens ◽  
Hans Geyer ◽  
Wilhelm Schänzer
Keyword(s):  
Growth Hormone ◽  
Human Urine ◽  
Doping Control ◽  
Growth Hormone Secretagogue

A CHEMICAL METHOD FOR THE DETERMINATION OF 2-HYDROXYOESTRONE IN HUMAN URINE

1973 ◽  
Vol 71 (4_Suppl) ◽  
pp. S110
Author(s):  
H. P. Gelbke ◽  
R. Knuppen
Keyword(s):  
Human Urine ◽  
Chemical Method

DETERMINATION OF AFTER-RIPENING PERIOD AND HORMONAL RESPONSE OF OROBANCHE SOLMSII C.D. CLARKE SEEDS

1970 ◽  
Vol 11 (1) ◽  
Author(s):  
A. Bista ◽  
G. B. Khattri ◽  
B. D. Acharya ◽  
S. C. Srivastava
Keyword(s):  
Growth Hormone ◽  
Seed Germination ◽  
Key Words ◽  
Incubation Period ◽  
Seed Set ◽  
Summer Season ◽  
Conditioning Period ◽  
Root Parasite ◽  
One Year

To find out the ability of Orobanche seeds to germinate immediately after seed set, seeds were germinated periodically at an interval of three months for one year in GR24. Some Orobanche seeds were capable of germination immediately after seed set but most required about nine months as after ripening or incubation period to be able to germinate. The phenomenon of after ripening in Orobanche seeds could be taken as an ecological measure to dormant over following unfavorable wet summer season. The growth hormone studies on Orobanche seed germination have shown that GA3 at a concentration of 100 ppm substantially enhanced seed germination when applied during pre-conditioning period. NAA showed some stimulatory effect at 0.5 - 1.0 ppm when applied during post-conditioning period but the hormone if applied during pre-conditioning period inhibited the germination. Kinetin failed to stimulate the germination at all the concentrations tested. Key words: Germination, root-parasite, hormone. Ecoprint Vol.11(1) 2004.

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