scholarly journals Cortical and Commissural Defects Upon HCF‐1 Loss in Nkx2.1 ‐Derived Embryonic Neurons and Glia

2019 ◽  
Vol 79 (6) ◽  
pp. 578-595 ◽  
Author(s):  
Shilpi Minocha ◽  
Winship Herr
Keyword(s):  
Embryonic Neurons

Pregnenolone metabolism in rodent embryonic neurons and astrocytes

Glia ◽  
1993 ◽  
Vol 7 (2) ◽  
pp. 170-175 ◽  
Author(s):  
Khadija Kabbadj ◽  
Martine El-Etr ◽  
Etienne-Emile Baulieu ◽  
Paul Robel
Keyword(s):  
Embryonic Neurons

scholarly journals Coupling of terminal differentiation deficit with neurodegenerative pathology in Vps35-deficient pyramidal neurons

2020 ◽  
Vol 27 (7) ◽  
pp. 2099-2116 ◽  
Author(s):  
Fu-Lei Tang ◽  
Lu Zhao ◽  
Yang Zhao ◽  
Dong Sun ◽  
Xiao-Juan Zhu ◽  
...  
Keyword(s):  
Protein Trafficking ◽  
Pyramidal Neurons ◽  
Transmembrane Protein ◽  
Terminal Differentiation ◽  
Physiological Role ◽  
Neurodegenerative Pathology ◽  
Associated Proteins ◽  
Developing Neurons ◽  
Vacuolar Protein ◽  
Embryonic Neurons

AbstractVps35 (vacuolar protein sorting 35) is a key component of retromer that regulates transmembrane protein trafficking. Dysfunctional Vps35 is a risk factor for neurodegenerative diseases, including Parkinson’s and Alzheimer’s diseases. Vps35 is highly expressed in developing pyramidal neurons, and its physiological role in developing neurons remains to be explored. Here, we provide evidence that Vps35 in embryonic neurons is necessary for axonal and dendritic terminal differentiation. Loss of Vps35 in embryonic neurons results in not only terminal differentiation deficits, but also neurodegenerative pathology, such as cortical brain atrophy and reactive glial responses. The atrophy of neocortex appears to be in association with increases in neuronal death, autophagosome proteins (LC3-II and P62), and neurodegeneration associated proteins (TDP43 and ubiquitin-conjugated proteins). Further studies reveal an increase of retromer cargo protein, sortilin1 (Sort1), in lysosomes of Vps35-KO neurons, and lysosomal dysfunction. Suppression of Sort1 diminishes Vps35-KO-induced dendritic defects. Expression of lysosomal Sort1 recapitulates Vps35-KO-induced phenotypes. Together, these results demonstrate embryonic neuronal Vps35’s function in terminal axonal and dendritic differentiation, reveal an association of terminal differentiation deficit with neurodegenerative pathology, and uncover an important lysosomal contribution to both events.

scholarly journals Interactions during a critical period inhibit bilateral projections in embryonic neurons

1995 ◽  
Vol 15 (2) ◽  
pp. 1506-1515 ◽  
Author(s):  
LR Wolszon ◽  
MB Passani ◽  
ER Macagno
Keyword(s):  
Critical Period ◽  
Embryonic Neurons
Sign in / Sign up

Export Citation Format

Share Document