Metabotropic glutamate receptor 5 responses dictate differentiation of neural progenitors to NMDA-responsive cells in fragile X syndrome

2016 ◽  
Vol 77 (4) ◽  
pp. 438-453 ◽  
Author(s):  
Venkat Swaroop Achuta ◽  
Heli Grym ◽  
Noora Putkonen ◽  
Verna Louhivuori ◽  
Virve Kärkkäinen ◽  
...  
Keyword(s):  
Fragile X Syndrome ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Fragile X ◽  
Neural Progenitors ◽  
Metabotropic Glutamate Receptor 5 ◽  
Metabotropic Glutamate

Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome

2015 ◽  
Vol 20 ◽  
pp. 124-134 ◽  
Author(s):  
Sebastian H Scharf ◽  
Georg Jaeschke ◽  
Joseph G Wettstein ◽  
Lothar Lindemann
Keyword(s):  
Fragile X Syndrome ◽  
Glutamate Receptor ◽  
Drug Target ◽  
Metabotropic Glutamate Receptor ◽  
Fragile X ◽  
Metabotropic Glutamate Receptor 5 ◽  
Metabotropic Glutamate

Fragile X syndrome: a preclinical review on metabotropic glutamate receptor 5 (mGluR5) antagonists and drug development

2013 ◽  
Vol 231 (6) ◽  
pp. 1217-1226 ◽  
Author(s):  
Andreea S. Pop ◽  
Baltazar Gomez-Mancilla ◽  
Giovanni Neri ◽  
Rob Willemsen ◽  
Fabrizio Gasparini
Keyword(s):  
Drug Development ◽  
Fragile X Syndrome ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Fragile X ◽  
Metabotropic Glutamate Receptor 5 ◽  
Metabotropic Glutamate

scholarly journals Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?

2013 ◽  
Vol 4 (1) ◽  
pp. 15 ◽  
Author(s):  
Talakad G Lohith ◽  
Emily K Osterweil ◽  
Masahiro Fujita ◽  
Kimberly J Jenko ◽  
Mark F Bear ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Fragile X Syndrome ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Fragile X ◽  
Metabotropic Glutamate Receptor 5 ◽  
Metabotropic Glutamate

scholarly journals Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Idiopathic Autism Spectrum Disorder and Fragile X Syndrome: A Pilot Study

2021 ◽  
Vol 22 (6) ◽  
pp. 2863
Author(s):  
James Robert Brašić ◽  
Ayon Nandi ◽  
David S. Russell ◽  
Danna Jennings ◽  
Olivier Barret ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Fragile X Syndrome ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Fragile X ◽  
Single Gene ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Receptor Subtype ◽  
Metabotropic Glutamate

Multiple lines of evidence suggest that dysfunction of the metabotropic glutamate receptor subtype 5 (mGluR5) plays a role in the pathogenesis of autism spectrum disorder (ASD). Yet animal and human investigations of mGluR5 expression provide conflicting findings about the nature of dysregulation of cerebral mGluR5 pathways in subtypes of ASD. The demonstration of reduced mGluR5 expression throughout the living brains of men with fragile X syndrome (FXS), the most common known single-gene cause of ASD, provides a clue to examine mGluR5 expression in ASD. We aimed to (A) compare and contrast mGluR5 expression in idiopathic autism spectrum disorder (IASD), FXS, and typical development (TD) and (B) show the value of positron emission tomography (PET) for the application of precision medicine for the diagnosis and treatment of individuals with IASD, FXS, and related conditions. Two teams of investigators independently administered 3-[18F]fluoro-5-(2-pyridinylethynyl)benzonitrile ([18F]FPEB), a novel, specific mGluR5 PET ligand to quantitatively measure the density and the distribution of mGluR5s in the brain regions, to participants of both sexes with IASD and TD and men with FXS. In contrast to participants with TD, mGluR5 expression was significantly increased in the cortical regions of participants with IASD and significantly reduced in all regions of men with FXS. These results suggest the feasibility of this protocol as a valuable tool to measure mGluR5 expression in clinical trials of individuals with IASD and FXS and related conditions.

scholarly journals β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X

Cell Reports ◽  
2017 ◽  
Vol 18 (12) ◽  
pp. 2807-2814 ◽  
Author(s):  
Laura J. Stoppel ◽  
Benjamin D. Auerbach ◽  
Rebecca K. Senter ◽  
Anthony R. Preza ◽  
Robert J. Lefkowitz ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Fragile X ◽  
Metabotropic Glutamate Receptor 5 ◽  
Metabotropic Glutamate ◽  
Neuronal Protein ◽  
Potential Target
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