scholarly journals mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons

2016 ◽  
Vol 76 (12) ◽  
pp. 1308-1327 ◽  
Author(s):  
Agnieszka Skalecka ◽  
Ewa Liszewska ◽  
Robert Bilinski ◽  
Christos Gkogkas ◽  
Arkady Khoutorsky ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Mtor Kinase ◽  
Dendritic Arbors ◽  
Olfactory Bulb Neurons

Kinetic variability of AMPA receptors among olfactory bulb neurons in culture

Neuroreport ◽  
2003 ◽  
Vol 14 (7) ◽  
pp. 965-970 ◽  
Author(s):  
Laura J. Blakemore ◽  
Paul Q. Trombley
Keyword(s):  
Olfactory Bulb ◽  
Ampa Receptors ◽  
Olfactory Bulb Neurons

scholarly journals Brief sensory deprivation triggers cell type-specific structural and functional plasticity in olfactory bulb neurons

2021 ◽  
pp. JN-RM-1606-20
Author(s):  
Elisa Galliano ◽  
Christiane Hahn ◽  
Lorcan P. Browne ◽  
Paula R. Villamayor ◽  
Candida Tufo ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Sensory Deprivation ◽  
Cell Type ◽  
Functional Plasticity ◽  
Cell Type Specific ◽  
Olfactory Bulb Neurons

scholarly journals Hyperhomocysteinemia induces injury in olfactory bulb neurons by downregulating Hes1 and Hes5 expression

2018 ◽  
Vol 13 (2) ◽  
pp. 272 ◽  
Author(s):  
Yi-li Wang ◽  
Li Jing ◽  
Jing-wen Zhang ◽  
Bo Pang ◽  
Qi Zhao ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Olfactory Bulb Neurons

Distribution and Activation of Intracellular Ca2+ Stores in Cultured Olfactory Bulb Neurons

1997 ◽  
Vol 78 (4) ◽  
pp. 2176-2185 ◽  
Author(s):  
Greg C. Carlson ◽  
Melissa L. Slawecki ◽  
Eric Lancaster ◽  
Asaf Keller
Keyword(s):  
Olfactory Bulb ◽  
Ryanodine Receptor ◽  
Acid Decarboxylase ◽  
Cultured Neurons ◽  
Local Pressure ◽  
Intracellular Release ◽  
Intracellular Ca ◽  
Almost All ◽  
Olfactory Bulb Neurons

Carlson, Greg C., Melissa L. Slawecki, Eric Lancaster, and Asaf Keller. Distribution and activation of intracellular Ca2+ stores in cultured olfactory bulb neurons. J. Neurophysiol. 78: 2176–2185, 1997. The presence and distribution of intracellular Ca2+ release pathways in olfactory bulb neurons were studied in dissociated cell cultures. Histochemical techniques and imaging of Ca2+ fluxes were used to identify two major intracellular Ca2+ release mechanisms: inositol 1,4,5-triphosphate receptor (IP3R)-mediated release, and ryanodine receptor-mediated release. Cultured neurons were identified by immunocytochemistry for the neuron-specificmarker β-tubulin III. Morphometric analyses and immunocytochemistry for glutamic acid-decarboxylase revealed a heterogeneous population of cultured neurons with phenotypes corresponding to both projection (mitral/tufted) and intrinsic (periglomerular/granule) neurons of the in vivo olfactory bulb. Immunocytochemistry for the IP3R, and labeling with fluorescent-tagged ryanodine, revealed that, irrespective of cell type, almost all cultured neurons express IP3R and ryanodine binding sites in both somata and dendrites. Functional imaging revealed that intracellular Ca2+ fluxes can be generated in the absence of external Ca2+, using agonists specific to each of the intracellular release pathways. Local pressure application of glutamate or quisqualate evoked Ca2+ fluxes in both somata and dendrites in nominally Ca2+ free extracellular solutions, suggesting the presence of IP3-dependent Ca2+ release. These fluxes were blocked by preincubation with thapsigargin and persisted in the presence of the glutamate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione. Local application of caffeine, a ryanodine receptor agonist, also evoked intracellular Ca2+ fluxes in the absence of extracellular Ca2+. These Ca2+ fluxes were suppressed by preincubation with ryanodine. In all neurons, both IP3- and ryanodine-dependent release pathways coexisted, suggesting that they interact to modulate intracellular Ca2+ concentrations.

Postnatal proliferation and maturation of olfactory bulb neurons in the rat

Neuroscience ◽  
1982 ◽  
Vol 7 (12) ◽  
pp. 3105-3116 ◽  
Author(s):  
R.G. Mair ◽  
R.L. Gellman ◽  
R.C. Gesteland
Keyword(s):  
Olfactory Bulb ◽  
Olfactory Bulb Neurons
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