Serotonin promotes feminization of the sexually dimorphic nucleus of the preoptic area, but not the calbindin cell group

2016 ◽  
Vol 76 (11) ◽  
pp. 1241-1253 ◽  
Author(s):  
Amanda M. K. Madden ◽  
Alexandria T. Paul ◽  
Rory A. Pritchard ◽  
Rebecca Michel ◽  
Susan L. Zup
Keyword(s):  
Preoptic Area ◽  
Cell Group ◽  
Sexually Dimorphic ◽  
Sexually Dimorphic Nucleus

scholarly journals The Volume of a Sexually Dimorphic Nucleus in the Ovine Medial Preoptic Area/Anterior Hypothalamus Varies with Sexual Partner Preference

Endocrinology ◽  
2004 ◽  
Vol 145 (2) ◽  
pp. 478-483 ◽  
Author(s):  
Charles E. Roselli ◽  
Kay Larkin ◽  
John A. Resko ◽  
John N. Stellflug ◽  
Fred Stormshak
Keyword(s):  
Sexual Partner ◽  
Preoptic Area ◽  
Medial Preoptic Area ◽  
Anterior Hypothalamus ◽  
Cell Group ◽  
Sexually Dimorphic ◽  
Mrna Levels ◽  
Sexual Preferences ◽  
Estrogen Synthesis ◽  
Sexually Dimorphic Nucleus

Abstract Sheep are one of the few animal models in which natural variations in male sexual preferences have been studied experimentally. Approximately 8% of rams exhibit sexual preferences for male partners (male-oriented rams) in contrast to most rams, which prefer female partners (female-oriented rams). We identified a cell group within the medial preoptic area/anterior hypothalamus of age-matched adult sheep that was significantly larger in adult rams than in ewes. This cell group was labeled the ovine sexually dimorphic nucleus (oSDN). In addition to a sex difference, we found that the volume of the oSDN was two times greater in female-oriented rams than in male-oriented rams. The dense cluster of neurons that comprise the oSDN express cytochrome P450 aromatase. Aromatase mRNA levels in the oSDN were significantly greater in female-oriented rams than in ewes, whereas male-oriented rams exhibited intermediate levels of expression. Because the medial preoptic area/anterior hypothalamus is known to control the expression of male sexual behaviors, these results suggest that naturally occurring variations in sexual partner preferences may be related to differences in brain anatomy and capacity for estrogen synthesis.

Perinatal Androgenization Prevents Age-Related Neuron Loss in the Sexually Dimorphic Nucleus of the Preoptic Area in Female Rats

2004 ◽  
Vol 26 (1) ◽  
pp. 54-60 ◽  
Author(s):  
Shaw-Lang Yang ◽  
Yu-Yang Chen ◽  
Ya-Lun Hsieh ◽  
Su-Hwa Jin ◽  
Hseng-Kuang Hsu ◽  
...  
Keyword(s):  
Preoptic Area ◽  
Female Rats ◽  
Sexually Dimorphic ◽  
Neuron Loss ◽  
Age Related ◽  
Sexually Dimorphic Nucleus

scholarly journals Estrogen Receptor α Gene Promoter 0/B Usage in the Rat Sexually Dimorphic Nucleus of the Preoptic Area

Endocrinology ◽  
2010 ◽  
Vol 151 (4) ◽  
pp. 1923-1928 ◽  
Author(s):  
Tomohiro Hamada ◽  
Yasuo Sakuma
Keyword(s):  
Estrogen Receptor ◽  
Sexual Differentiation ◽  
Preoptic Area ◽  
Gene Promoter ◽  
Estrogen Receptor Α ◽  
Egfp Expression ◽  
Sexually Dimorphic ◽  
Transgenic Rats ◽  
The Core ◽  
Sexually Dimorphic Nucleus

The volume of the sexually dimorphic nucleus of the preoptic area (SDN-POA) is two to four times larger in male rats than in females; however, the mechanism for the establishment of sexual dimorphism and the function of this nucleus is almost unknown. Perinatal estrogen can cause sexual dimorphism via the estrogen receptor α (ERα). Recently, transgenic rats were generated that express enhanced green fluorescent protein (EGFP) under the control of the ERα gene promoter 0/B to tag ERα-positive neurons in the brain. In the present study, we examined whether this EGFP expression could be a marker for the SDN-POA in adults. EGFP-labeled cells were distributed in the core of the SDN-POA (0/B-SDN) of male and female transgenic rats, in accordance with the Nissl staining and immunoreactivity for the SDN marker, calbindin. They were also immunoreactive for ERα. The core was bigger in volume and contained more 0/B-SDN neurons in males than in females. The EGFP-tagged cells were packed more densely in the female core than that in males. Subcutaneous injection of 100 μg 17β-estradiol to females on the day of birth, or orchidectomy of male neonates, reversed the sexually dimorphic phenotype of the volume of the 0/B-SDN, despite not affecting the cell number. We suggest that this EGFP expression in the SDN-POA could be a useful marker to clarify the sexual differentiation and function of the SDN-POA. Moreover, the ERα gene promoter 0/B plays a key role in the organization of the sexual differentiation of the SDN-POA.

NEUROPROTECTIVE ROLE OF NELL2 IN THE SEXUALLY DIMORPHIC NUCLEUS OF THE MALE RAT PREOPTIC AREA

2007 ◽  
Vol 77 (Suppl_1) ◽  
pp. 105-105
Author(s):  
Byung Ju Lee ◽  
Jin Kwon Jeong ◽  
Joong Jean Park
Keyword(s):  
Preoptic Area ◽  
Male Rat ◽  
Sexually Dimorphic ◽  
Sexually Dimorphic Nucleus
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