Adolescent vulnerability to cardiovascular consequences of chronic social stress: Immediate and long-term effects of social isolation during adolescence

2015 ◽  
Vol 76 (1) ◽  
pp. 34-46 ◽  
Author(s):  
Fábio C. Cruz ◽  
Josiane O. Duarte ◽  
Rodrigo M. Leão ◽  
Luiz F.V. Hummel ◽  
Cleopatra S. Planeta ◽  
...  
Keyword(s):  
Social Isolation ◽  
Social Stress ◽  
Long Term Effects ◽  
Chronic Social Stress

Long-term effects of chronic social stress on serotonergic indices in the prefrontal cortex of adult male cynomolgus macaques

1995 ◽  
Vol 705 (1-2) ◽  
pp. 105-108 ◽  
Author(s):  
M. Babette Fontenot ◽  
Jay R. Kaplan ◽  
Stephen B. Manuck ◽  
Victoria Arango ◽  
J. John Mann
Keyword(s):  
Prefrontal Cortex ◽  
Adult Male ◽  
Social Stress ◽  
Long Term Effects ◽  
Chronic Social Stress ◽  
Cynomolgus Macaques

scholarly journals Long-term effects of early social isolation in Macaca mulatta: changes in dopamine receptor function following apomorphine challenge

1990 ◽  
Vol 513 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Mark H. Lewis ◽  
John P. Gluck ◽  
Alan J. Beauchamp ◽  
Michael F. Keresztury ◽  
Richard B. Mailman
Keyword(s):  
Dopamine Receptor ◽  
Social Isolation ◽  
Macaca Mulatta ◽  
Receptor Function ◽  
Long Term Effects

scholarly journals Long-Term Impacts of Post-weaning Social Isolation on Nucleus Accumbens Function

2021 ◽  
Vol 12 ◽  
Author(s):  
Cari J. Bendersky ◽  
Allison A. Milian ◽  
Mason D. Andrus ◽  
Ubaldo De La Torre ◽  
Deena M. Walker
Keyword(s):  
Nucleus Accumbens ◽  
Social Isolation ◽  
Medium Spiny Neurons ◽  
Long Term Effects ◽  
Self Administration ◽  
Reward Circuitry ◽  
Specific Effects ◽  
Dopamine Receptor 1 ◽  
First Time

Adolescence is a period of incredible change, especially within the brain's reward circuitry. Stress, including social isolation, during this time has profound effects on behaviors associated with reward and other neuropsychiatric disorders. Because the Nucleus Accumbens (NAc), is crucial to the integration of rewarding stimuli, the NAc is especially sensitive to disruptions by adolescent social isolation stress. This review highlights the long-term behavioral consequences of adolescent social isolation rearing on the NAc. It will discuss the cellular and molecular changes within the NAc that might underlie the long-term effects on behavior. When available sex-specific effects are discussed. Finally by mining publicly available data we identify, for the first time, key transcriptional profiles induced by adolescence social isolation in genes associated with dopamine receptor 1 and 2 medium spiny neurons and genes associated with cocaine self-administration. Together, this review provides a comprehensive discussion of the wide-ranging long-term impacts of adolescent social isolation on the dopaminergic system from molecules through behavior.

scholarly journals Sex differences in chronic social stress models in mice

2019 ◽  
Author(s):  
Orit Furman ◽  
Michael Tsoory ◽  
Alon Chen
Keyword(s):  
Sex Differences ◽  
Animal Models ◽  
Mouse Model ◽  
Treatment Response ◽  
Chronic Stress ◽  
Social Stress ◽  
Molecular Mechanisms ◽  
Body Weight Loss ◽  
Chronic Social Stress

AbstractChronic stress creates an allostatic overload that may lead to mood disorders such as anxiety and depression. Modern causes of chronic stress in humans are mostly social in nature, relating to work and relationship stress. Research into neural and molecular mechanisms of vulnerability and resilience following chronic social stress (CSS) is ongoing and uses animal models to discover efficient prevention strategies and treatments. To date, most CSS studies have neglected the female sex and used male-focused aggression-based animal models such as chronic social defeat stress (CSDS). Accumulating evidence on sex differences suggests differences in the stress response, the prevalence of stress-related illness and the treatment response, indicating that researchers should expand CSS investigation to include female-focused protocols alongside the popular CSDS protocols. Here, we describe a novel female mouse model of CSS and a parallel modified male mouse model of CSDS in C57BL/6 mice. These new models enable the investigation of vulnerability, coping and downstream effectors mediating long-term consequences of CSS in both sexes. Our data demonstrate sex differences during CSS and for many weeks following CSS. Female mice are more prone to body weight loss during CSS and hyperactive anxious behavior following CSS. Both sexes show disturbances in social interaction, but only stressed male mice show long-term changes in neuroendocrine function and memory performance after fear conditioning. We discuss future avenues of research using these models to investigate mechanisms pertaining to sensitivity to CSS as well as treatment response profiles, in a sex-suitable manner.

Long-Term Effects of Total Social Isolation Upon Behavior of Rhesus Monkeys

1966 ◽  
Vol 18 (2) ◽  
pp. 567-580 ◽  
Author(s):  
G. D. Mitchell ◽  
E. J. Raymond ◽  
G. C. Ruppenthal ◽  
H. F. Harlow
Keyword(s):  
Social Behavior ◽  
Social Isolation ◽  
Rhesus Monkeys ◽  
First Year ◽  
Long Term Effects ◽  
Negative Effects ◽  
Cross Sectional ◽  
Follow Up Study

8 isolate monkeys were compared in a follow-up study to 8 sophisticated controls in brief cross-sectional pairings with 12 stimulus strangers: 4 adults, 4 age-mates, and 4 juveniles. The isolates were characterized by infantile disturbance, less environmental orality, more fear, more aggression, less sex, less play, and bizarre ritualistic movements. 12-mo. isolates were fearful and nonaggressive but threatened many attacks. 6-mo. isolates were fearful and physically aggressive. The 12-mo. isolates demonstrated practically no positive social behavior. Conclusions are: (a) 6 mo. of social isolation during the first year has negative effects on social behavior up to puberty, (b) abnormal aggression appears in 3-yr.-old 6-mo. isolates, and (c) 12 mo. of isolation suppress or delay this aggression.

COVID-19: implications of self-isolation and social distancing for the emotional and behavioural health of dogs

2020 ◽  
Vol 25 (4) ◽  
pp. 1-8
Author(s):  
Claire Hargrave
Keyword(s):  
Social Isolation ◽  
Human Population ◽  
Companion Animals ◽  
Long Term Effects ◽  
Social Stimulation ◽  
Behavioural Health ◽  
The World ◽  
The Media ◽  
Social Exposure

As the COVID-19 pandemic sweeps across the world, governments are taking unprecedented steps to achieve control and reduction of its affects. Although the potential mental and behavioural health challenges of social isolation for the human population has been widely discussed within the media, less has been said of the concurrent challenges faced by the companion animals that are also experiencing the regulations associated with ‘lock-down’ and ‘self-isolation’. This article considers the immediate consequences for dogs of reduced access to environmental and social stimulation outside the home and increased social exposure within the home, as well as considering some of the potential long-term effects of such measures.

Long-term behavioral and neuroendocrine alterations following chronic social stress in mice: Implications for stress-related disorders

2008 ◽  
Vol 53 (2) ◽  
pp. 386-394 ◽  
Author(s):  
Vera Sterlemann ◽  
Karin Ganea ◽  
Claudia Liebl ◽  
Daniela Harbich ◽  
Stephanie Alam ◽  
...  
Keyword(s):  
Social Stress ◽  
Chronic Social Stress
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