Dark rearing alters the normal development of spatiotemporal response properties but not of contrast detection threshold in mouse retinal ganglion cells

2014 ◽  
Vol 74 (7) ◽  
pp. 692-706 ◽  
Author(s):  
Nikolay P. Akimov ◽  
René C. Rentería
Keyword(s):  
Retinal Ganglion Cells ◽  
Normal Development ◽  
Ganglion Cells ◽  
Detection Threshold ◽  
Retinal Ganglion ◽  
Response Properties ◽  
Contrast Detection ◽  
Spatiotemporal Response ◽  
Dark Rearing

Pathways of regenerated retinotectal axons in goldfish

Development ◽  
1986 ◽  
Vol 93 (1) ◽  
pp. 1-28
Author(s):  
Claudia A. O. Stuermer
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Normal Development ◽  
Ganglion Cells ◽  
Optic Tract ◽  
Spatiotemporal Pattern ◽  
Retinal Ganglion ◽  
Retinal Axons ◽  
Age Related ◽  
Regenerated Fibres

This study investigates the order of regenerating retinal axons in the goldfish. The spatiotemporal pattern of axon regrowth was assessed by applying horseradish peroxidase (HRP) to regenerating axons in the optic tract at various times after optic nerve section and by analysing the distribution of retrogradely labelled ganglion cells in retina. At all regeneration stages labelled ganglion cells were widely distributed over the retina. There was no hint that axons from central (older) ganglion cells might regrow earlier, and peripheral (younger) ganglion cells later, as occurs in normal development. The absence of an age-related ordering in the regenerated optic nerve was demonstrated by labelling a few axon bundles intraorbitally with HRP (Easter, Rusoff & Kish, 1981) caudal to the previous cut. The retrogradely labelled cells in retina were randomly distributed in regenerates andnot clustered in annuli as in normals. Tracing regenerating axons which were stained anterogradelyfrom intraretinal HRP applications or retrogradely from single labelled tectal fascicles illustrated the fact that the regenerating axons coursed in abnormal routes in the optic nerve and tract. On the surface of the tectum regenerated fibres re-established a fascicle fan. The retinal origin of tectal fascicles was assessed by labelling individual peripheral, intermediate and rostral fascicles with HRP. The retrogradely labelled ganglion cells in the retina were often more widely distributed than in normals, but were mostly found in peripheral, intermediate and central retina, respectively. The order of fibre departure from each tectal fascicle was revealed by placing HRP either on the fascicle's proximal or on its distal half. With proximal labelling sites labelled ganglion cells were found in the temporal and nasal retina, and with distal labelling sites labelled ganglion cells were confined to nasal retina only. Further, the axonal trajectories of anterogradely labelled dorsotemporal retinal ganglion cells were compared to those of dorsonasal retinal ganglion cells in tectal whole mounts. Dorsotemporal axons were confined to the rostral tectal half, whereas dorsonasal axons followed fascicular routes into the fascicles' distal end and reached into caudal tectum. This suggests that the fibres exited along their fascicle's course in a temporonasal sequence. Thus in the tectum, fibres in fascicles restore a gross spatial and age-related order and tend to follow their normal temporonasal sequence of exit.

scholarly journals Physiological characterization of a rare subpopulation of doublet-spiking neurons in the ferret lateral geniculate nucleus

2020 ◽  
Vol 124 (2) ◽  
pp. 432-442
Author(s):  
Allison J. Murphy ◽  
J. Michael Hasse ◽  
Farran Briggs
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Visual Response ◽  
Retinal Ganglion ◽  
Visual Responses ◽  
Response Properties ◽  
Physiological Characterization ◽  
Visual Thalamus ◽  
Spike Shape

Interest in visual system homologies across species has recently increased. Across species, retinas contain diverse retinal ganglion cells including cells with unusual visual response properties. It is unclear whether rare retinal ganglion cells in carnivores project to and drive similarly unique visual responses in the visual thalamus. We discovered a rare subpopulation of thalamic neurons defined by unique spike shape and visual response properties, suggesting that nonstandard visual computations are common to many species.

scholarly journals Melanopsin-Encoded Response Properties of Intrinsically Photosensitive Retinal Ganglion Cells

Neuron ◽  
2016 ◽  
Vol 90 (5) ◽  
pp. 1016-1027 ◽  
Author(s):  
Ludovic S. Mure ◽  
Megumi Hatori ◽  
Quansheng Zhu ◽  
James Demas ◽  
Irene M. Kim ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Retinal Ganglion ◽  
Response Properties

Response properties of ON–OFF retinal ganglion cells to high-order stimulus statistics

2014 ◽  
Vol 582 ◽  
pp. 43-48 ◽  
Author(s):  
Lei Xiao ◽  
Han-Yan Gong ◽  
Hai-Qing Gong ◽  
Pei-Ji Liang ◽  
Pu-Ming Zhang
Keyword(s):  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
High Order ◽  
Retinal Ganglion ◽  
Response Properties
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