Relationship between GABAergic interneurons migration and early neocortical network activity

2009 ◽  
Vol 69 (2-3) ◽  
pp. 105-123 ◽  
Author(s):  
Ana D. de Lima ◽  
Anne Gieseler ◽  
Thomas Voigt
Keyword(s):  
Network Activity ◽  
Gabaergic Interneurons ◽  
Neocortical Network

Endocannabinoid system in the neurodevelopment of GABAergic interneurons: implications for neurological and psychiatric disorders

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Chang-geng Song ◽  
Xin Kang ◽  
Fang Yang ◽  
Wan-qing Du ◽  
Jia-jia Zhang ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Endocannabinoid System ◽  
Autism Spectrum ◽  
Network Activity ◽  
Inhibitory Neurons ◽  
Gabaergic Interneurons ◽  
Neural Stem Progenitor Cells ◽  
The Central Nervous System ◽  
Interneuron Development

Abstract In mature mammalian brains, the endocannabinoid system (ECS) plays an important role in the regulation of synaptic plasticity and the functioning of neural networks. Besides, the ECS also contributes to the neurodevelopment of the central nervous system. Due to the increase in the medical and recreational use of cannabis, it is inevitable and essential to elaborate the roles of the ECS on neurodevelopment. GABAergic interneurons represent a group of inhibitory neurons that are vital in controlling neural network activity. However, the role of the ECS in the neurodevelopment of GABAergic interneurons remains to be fully elucidated. In this review, we provide a brief introduction of the ECS and interneuron diversity. We focus on the process of interneuron development and the role of ECS in the modulation of interneuron development, from the expansion of the neural stem/progenitor cells to the migration, specification and maturation of interneurons. We further discuss the potential implications of the ECS and interneurons in the pathogenesis of neurological and psychiatric disorders, including epilepsy, schizophrenia, major depressive disorder and autism spectrum disorder.

scholarly journals GABAergic interneurons excite neonatal hippocampus in vivo

2020 ◽  
Vol 6 (24) ◽  
pp. eaba1430 ◽  
Author(s):  
Yasunobu Murata ◽  
Matthew T. Colonnese
Keyword(s):  
Visual Cortex ◽  
Synapse Formation ◽  
Reversal Potential ◽  
Pyramidal Cells ◽  
Gabaergic Neurons ◽  
Network Activity ◽  
Gabaergic Interneuron ◽  
Gabaergic Interneurons ◽  
Early Postnatal Development

GABAergic interneurons are proposed to be critical for early activity and synapse formation by directly exciting, rather than inhibiting, neurons in developing hippocampus and neocortex. However, the role of GABAergic neurons in the generation of neonatal network activity has not been tested in vivo, and recent studies have challenged the excitatory nature of early GABA. By locally manipulating interneuron activity in unanesthetized neonatal mice, we show that GABAergic neurons are excitatory in CA1 hippocampus at postnatal day 3 (P3) and are responsible for most of the spontaneous firing of pyramidal cells at that age. Hippocampal interneurons become inhibitory by P7, whereas visual cortex interneurons are already inhibitory by P3 and remain so throughout development. These regional and age-specific differences are the result of a change in chloride reversal potential, because direct activation of light-gated anion channels in glutamatergic neurons drives CA1 firing at P3, but silences it at P7 in CA1, and at all ages in visual cortex. This study in the intact brain reveals that GABAergic interneuron excitation is essential for network activity in neonatal hippocampus and confirms that visual cortical interneurons are inhibitory throughout early postnatal development.

scholarly journals Internally Mediated Developmental Desynchronization of Neocortical Network Activity

2009 ◽  
Vol 29 (35) ◽  
pp. 10890-10899 ◽  
Author(s):  
P. Golshani ◽  
J. T. Goncalves ◽  
S. Khoshkhoo ◽  
R. Mostany ◽  
S. Smirnakis ◽  
...  
Keyword(s):  
Network Activity ◽  
Neocortical Network

scholarly journals Endogenous Electric Fields May Guide Neocortical Network Activity

Neuron ◽  
2010 ◽  
Vol 67 (1) ◽  
pp. 129-143 ◽  
Author(s):  
Flavio Fröhlich ◽  
David A. McCormick
Keyword(s):  
Electric Fields ◽  
Network Activity ◽  
Neocortical Network

scholarly journals Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneurons

2020 ◽  
Vol 29 (15) ◽  
pp. 2579-2595
Author(s):  
George Andrew S Inglis ◽  
Ying Zhou ◽  
Dillon G Patterson ◽  
Christopher D Scharer ◽  
Yanfei Han ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Regulatory Networks ◽  
Induced Pluripotent Stem Cell ◽  
Regulatory Elements ◽  
Temporal Changes ◽  
Network Activity ◽  
Inhibitory Neurons ◽  
Molecular Networks ◽  
Gabaergic Interneurons

Abstract GABAergic interneurons (GINs) are a heterogeneous population of inhibitory neurons that collectively contribute to the maintenance of normal neuronal excitability and network activity. Identification of the genetic regulatory elements and transcription factors that contribute toward GIN function may provide new insight into the pathways underlying proper GIN activity while also indicating potential therapeutic targets for GIN-associated disorders, such as schizophrenia and epilepsy. In this study, we examined the temporal changes in gene expression and chromatin accessibility during GIN development by performing transcriptomic and epigenomic analyses on human induced pluripotent stem cell-derived neurons at 22, 50 and 78 days (D) post-differentiation. We observed 13 221 differentially accessible regions (DARs) of chromatin that associate with temporal changes in gene expression at D78 and D50, relative to D22. We also classified families of transcription factors that are increasingly enriched at DARs during differentiation, indicating regulatory networks that likely drive GIN development. Collectively, these data provide a resource for examining the molecular networks regulating GIN functionality.

Adenosine Down-Regulates Giant Depolarizing Potentials in the Developing Rat Hippocampus by Exerting a Negative Control on Glutamatergic Inputs

2005 ◽  
Vol 94 (4) ◽  
pp. 2797-2804 ◽  
Author(s):  
Victoria F. Safiulina ◽  
Alexander M. Kasyanov ◽  
Rashid Giniatullin ◽  
Enrico Cherubini
Keyword(s):  
Inhibitory Action ◽  
Hippocampal Slices ◽  
Negative Control ◽  
Rat Hippocampus ◽  
Neonatal Rat ◽  
Network Activity ◽  
Breakdown Product ◽  
Gabaergic Interneurons ◽  
Principal Cells ◽  
Whole Cell Patch Clamp

Adenosine is a widespread neuromodulator that can be directly released in the extracellular space during sustained network activity or can be generated as the breakdown product of adenosine triphosphate (ATP). Whole cell patch-clamp recordings were performed from CA3 principal cells and interneurons in hippocampal slices obtained from P2–P7 neonatal rats to study the modulatory effects of adenosine on giant depolarizing potentials (GDPs) that constitute the hallmark of developmental networks. We found that GDPs were extremely sensitive to the inhibitory action of adenosine (IC50 = 0.52 μM). Adenosine also contributed to the depressant effect of ATP as indicated by DPCPX-sensitive changes of ATP-induced reduction of GDP frequency. Similarly, adenosine exerted a strong inhibitory action on spontaneous glutamatergic synaptic events recorded from GABAergic interneurons and on interictal bursts that developed in CA3 principal cells after blockade of γ-aminobutyric acid type A (GABAA) receptors with bicuculline. All these effects were prevented by DPCPX, indicating the involvement of inhibitory A1 receptors. In contrast, GABAergic synaptic events were not changed by adenosine. Consistent with the endogenous role of adenosine on network activity, DPCPX per se increased the frequency of GDPs, interictal bursts, and spontaneous glutamatergic synaptic events recorded from GABAergic interneurons. Moreover, the adenosine transport inhibitor NBTI and the adenosine deaminase blocker EHNA decreased the frequency of GDPs, thus providing further evidence that endogenous adenosine exerts a powerful control on GDP generation. We conclude that, in the neonatal rat hippocampus, the inhibitory action of adenosine on GDPs arises from the negative control of glutamatergic, but not GABAergic, inputs.

Disruption of GABAA Receptors on GABAergic Interneurons Leads to Increased Oscillatory Power in the Olfactory Bulb Network

2001 ◽  
Vol 86 (6) ◽  
pp. 2823-2833 ◽  
Author(s):  
Zoltan Nusser ◽  
Leslie M. Kay ◽  
Gilles Laurent ◽  
Gregg E. Homanics ◽  
Istvan Mody
Keyword(s):  
Olfactory Bulb ◽  
Granule Cells ◽  
Fold Increase ◽  
Network Activity ◽  
Gabaergic Interneurons ◽  
Synaptic Inhibition ◽  
Principal Cells ◽  
Network Oscillations

Synchronized neural activity is believed to be essential for many CNS functions, including neuronal development, sensory perception, and memory formation. In several brain areas GABAA receptor–mediated synaptic inhibition is thought to be important for the generation of synchronous network activity. We have used GABAA receptor β3 subunit deficient mice (β3−/−) to study the role of GABAergic inhibition in the generation of network oscillations in the olfactory bulb (OB) and to reveal the role of such oscillations in olfaction. The expression of functional GABAA receptors was drastically reduced (>93%) in β3−/− granule cells, the local inhibitory interneurons of the OB. This was revealed by a large reduction of muscimol-evoked whole-cell current and the total current mediated by spontaneous, miniature inhibitory postsynaptic currents (mIPSCs). In β3−/− mitral/tufted cells (principal cells), there was a two-fold increase in mIPSC amplitudes without any significant change in their kinetics or frequency. In parallel with the altered inhibition, there was a significant increase in the amplitude of theta (80% increase) and gamma (178% increase) frequency oscillations in β3−/− OBs recorded in vivo from freely moving mice. In odor discrimination tests, we found β3−/− mice to be initially the same as, but better with experience than β3+/+ mice in distinguishing closely related monomolecular alcohols. However, β3−/− mice were initially better and then worse with practice than control mice in distinguishing closely related mixtures of alcohols. Our results indicate that the disruption of GABAAreceptor–mediated synaptic inhibition of GABAergic interneurons and the augmentation of IPSCs in principal cells result in increased network oscillations in the OB with complex effects on olfactory discrimination, which can be explained by an increase in the size or effective power of oscillating neural cell assemblies among the mitral cells of β3−/− mice.

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