scholarly journals Brief neonatal maternal separation alters extinction of conditioned fear and corticolimbic glucocorticoid and NMDA receptor expression in adult rats

2009 ◽  
Vol 69 (2-3) ◽  
pp. 73-87 ◽  
Author(s):  
Aaron A. Wilber ◽  
Christopher J. Southwood ◽  
Cara L. Wellman
Keyword(s):  
Nmda Receptor ◽  
Maternal Separation ◽  
Conditioned Fear ◽  
Receptor Expression ◽  
Adult Rats ◽  
Neonatal Maternal Separation

Neonatal maternal separation affects endocrine and metabolic stress responses to ether exposure but not to restraint exposure in adult rats

2008 ◽  
Vol 23 (4) ◽  
pp. 375-385 ◽  
Author(s):  
Daniela Rocha Costa Fóscolo ◽  
Rodrigo Bastos Fóscolo ◽  
Umeko Marubayashi ◽  
Adelina Martha Reis ◽  
Cândido Celso Coimbra
Keyword(s):  
Stress Responses ◽  
Maternal Separation ◽  
Metabolic Stress ◽  
Adult Rats ◽  
Neonatal Maternal Separation

Neonatal maternal separation of rat pups results in abnormal cholinergic regulation of epithelial permeability

2007 ◽  
Vol 293 (1) ◽  
pp. G198-G203 ◽  
Author(s):  
Mélanie G. Gareau ◽  
Jennifer Jury ◽  
Mary H. Perdue
Keyword(s):  
Maternal Separation ◽  
Mucosal Barrier ◽  
Epithelial Barrier ◽  
Epithelial Permeability ◽  
Barrier Dysfunction ◽  
Adult Rats ◽  
Western Blots ◽  
Ussing Chambers ◽  
Rat Pups ◽  
Neonatal Maternal Separation

Neonatal maternal separation (MS) predisposes adult rats to develop stress-induced mucosal barrier dysfunction/visceral hypersensitivity and rat pups to develop colonic epithelial dysfunction. Our aim was to examine if enhanced epithelial permeability in such pups resulted from abnormal regulation by enteric nerves. Pups were separated from the dam for 3 h/day ( days 4– 20); nonseparated (NS) pups served as controls. On day 20, colonic tissues were removed and mounted in Ussing chambers. Horseradish peroxidase (HRP) flux was used to measure macromolecular permeability. HRP flux was increased in MS versus NS pups. The enhanced flux was inhibited by the cholinergic muscarinic antagonist atropine and the nicotinic antagonist hexamethonium. The cholinergic component was greater in tissues from MS versus NS pups, suggesting that increased cholinergic activity was responsible for the MS elevated permeability. Western blots and immunohistochemistry of colonic tissues demonstrated increased expression of choline acetyltransferase (ChAT) in MS pups, indicating greater synthesis of acetylcholine. Since a previous study indicated that corticotrophin-releasing factor (CRF) mediates barrier dysfunction in MS pups, we examined if the two pathways were linked. In MS tissues, nonselective CRF receptor antagonism inhibited the enhanced flux, and the addition of atropine did not produce further inhibition. Using selective receptor antagonists, we identified that CRF receptor 2 was involved in mediating this effect. These findings suggest that CRF, via CRF receptor 2, acts on cholinergic nerves to induce epithelial barrier dysfunction. Our study provides evidence that MS stimulates synthesis of acetylcholine, which, together with released CRF, creates a condition conducive to the development of epithelial barrier defects.

Neonatal maternal separation results in stress-induced visceral hyperalgesia in adult rats: A new model for IBS

2000 ◽  
Vol 118 (4) ◽  
pp. A637 ◽  
Author(s):  
Santosh V. Coutinho ◽  
Marciano R. Sablad ◽  
Jerry C. Miller ◽  
Huping Zhou ◽  
Alan Lam ◽  
...  
Keyword(s):  
Maternal Separation ◽  
Visceral Hyperalgesia ◽  
Adult Rats ◽  
New Model ◽  
Neonatal Maternal Separation ◽  
Separation Results

scholarly journals Enhancement of the hypoxic ventilatory reponse in adult rats subjected to neonatal maternal separation is not affected by sleep‐wake states

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Richard Kinkead ◽  
Gaspard Montandon ◽  
Yves Lajeunesse ◽  
Aida Bairam ◽  
Richard Horner
Keyword(s):  
Maternal Separation ◽  
Adult Rats ◽  
Neonatal Maternal Separation
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