The vesicular integral protein-like gene is essential for development of a mechanosensory system in zebrafish

2008 ◽  
Vol 68 (12) ◽  
pp. 1391-1405 ◽  
Author(s):  
Mabel Chong ◽  
Meijiang Liao ◽  
Pierre Drapeau
Keyword(s):  
Integral Protein ◽  
Mechanosensory System

scholarly journals Expression of MAL2, an Integral Protein Component of the Machinery for Basolateral-to-Apical Transcytosis, in Human Epithelia

2004 ◽  
Vol 52 (2) ◽  
pp. 243-252 ◽  
Author(s):  
Mónica Marazuela ◽  
Agustín Acevedo ◽  
María Angeles García-López ◽  
Magdalena Adrados ◽  
María C. de Marco ◽  
...  
Keyword(s):  
Protein Component ◽  
Integral Protein

scholarly journals A mechanosensory system governs myosin II accumulation in dividing cells

2012 ◽  
Vol 23 (8) ◽  
pp. 1510-1523 ◽  
Author(s):  
Yee-Seir Kee ◽  
Yixin Ren ◽  
Danielle Dorfman ◽  
Miho Iijima ◽  
Richard Firtel ◽  
...  
Keyword(s):  
Mechanical Stress ◽  
Mitotic Spindle ◽  
Asymmetric Cell Division ◽  
Myosin Ii ◽  
Feedback Loops ◽  
Cleavage Furrow ◽  
Dividing Cells ◽  
Centromeric Protein ◽  
Protein Recruitment ◽  
Mechanosensory System

The mitotic spindle is generally considered the initiator of furrow ingression. However, recent studies suggest that furrows can form without spindles, particularly during asymmetric cell division. In Dictyostelium, the mechanoenzyme myosin II and the actin cross-linker cortexillin I form a mechanosensor that responds to mechanical stress, which could account for spindle-independent contractile protein recruitment. Here we show that the regulatory and contractility network composed of myosin II, cortexillin I, IQGAP2, kinesin-6 (kif12), and inner centromeric protein (INCENP) is a mechanical stress–responsive system. Myosin II and cortexillin I form the core mechanosensor, and mechanotransduction is mediated by IQGAP2 to kif12 and INCENP. In addition, IQGAP2 is antagonized by IQGAP1 to modulate the mechanoresponsiveness of the system, suggesting a possible mechanism for discriminating between mechanical and biochemical inputs. Furthermore, IQGAP2 is important for maintaining spindle morphology and kif12 and myosin II cleavage furrow recruitment. Cortexillin II is not directly involved in myosin II mechanosensitive accumulation, but without cortexillin I, cortexillin II's role in membrane–cortex attachment is revealed. Finally, the mitotic spindle is dispensable for the system. Overall, this mechanosensory system is structured like a control system characterized by mechanochemical feedback loops that regulate myosin II localization at sites of mechanical stress and the cleavage furrow.

scholarly journals A Mechanosensory System Governs Myosin II Cleavage Furrow Accumulation

2012 ◽  
Vol 102 (3) ◽  
pp. 349a
Author(s):  
Yee Seir Kee ◽  
Yixin Ren ◽  
Danielle Dorfman ◽  
Miho Iijima ◽  
Richard Firtel ◽  
...  
Keyword(s):  
Myosin Ii ◽  
Cleavage Furrow ◽  
Mechanosensory System

Brutonˈs tyrosine kinase-an integral protein of B cell development that also has an essential role in the innate immune system

2013 ◽  
Vol 95 (2) ◽  
pp. 243-250 ◽  
Author(s):  
Gabriela López-Herrera ◽  
Alexander Vargas-Hernández ◽  
Maria Edith González-Serrano ◽  
Laura Berrón-Ruiz ◽  
Juan Carlos Rodríguez-Alba ◽  
...  
Keyword(s):  
Immune System ◽  
Tyrosine Kinase ◽  
B Cell ◽  
Innate Immune System ◽  
Essential Role ◽  
Cell Development ◽  
B Cell Development ◽  
Innate Immune ◽  
Integral Protein
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