Diminished climbing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats

2007 ◽  
Vol 67 (7) ◽  
pp. 909-923 ◽  
Author(s):  
Yoshiko Takagishi ◽  
Kouichi Hashimoto ◽  
Tetsuro Kayahara ◽  
Masahiko Watanabe ◽  
Hiroyuki Otsuka ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Climbing Fiber ◽  
Mutant Mice ◽  
Myosin Va

303 Multiple climbing fiber innervation of cerebellar purkinje cells in mutant mice lacking the α-subunit of geterotrimeric G protein Gq(Gαq)

1997 ◽  
Vol 28 ◽  
pp. S54
Author(s):  
Kouichi Hashimoto ◽  
Stefan Offermanns ◽  
Masahiko Watanabe ◽  
Hideo Kurihara ◽  
Yoshiro Inoue ◽  
...  
Keyword(s):  
G Protein ◽  
Purkinje Cells ◽  
Climbing Fiber ◽  
Mutant Mice ◽  
Α Subunit ◽  
Cerebellar Purkinje Cells

302 Multiple climbing fiber innervation of cerebellar purkinje cells in mutant mice lacking the phospholipase C-β4 (PLC β4)

1997 ◽  
Vol 28 ◽  
pp. S53
Author(s):  
Masanobu Kano ◽  
Kouichi Hashimoto ◽  
Masahiko Watanabe ◽  
Hideo Kurihara ◽  
Yoshiro Inoue ◽  
...  
Keyword(s):  
Phospholipase C ◽  
Purkinje Cells ◽  
Climbing Fiber ◽  
Mutant Mice ◽  
Cerebellar Purkinje Cells

Normal adult climbing fiber monoinnervation of cerebellar Purkinje cells in mice lacking MHC class I molecules

2008 ◽  
Vol 68 (8) ◽  
pp. 997-1006 ◽  
Author(s):  
Mathieu Letellier ◽  
Melina L. Willson ◽  
Vanessa Gautheron ◽  
Jean Mariani ◽  
Ann M. Lohof
Keyword(s):  
Purkinje Cells ◽  
Mhc Class I ◽  
Climbing Fiber ◽  
Class I ◽  
Normal Adult ◽  
Cerebellar Purkinje Cells ◽  
Mhc Class I Molecules

scholarly journals Cerebellar and vestibular nuclear synapses in the inferior olive have distinct release kinetics and neurotransmitters

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Josef Turecek ◽  
Wade G Regehr
Keyword(s):  
Purkinje Cells ◽  
Inferior Olive ◽  
Release Kinetics ◽  
Vestibular Nuclei ◽  
Cerebellar Nuclei ◽  
Climbing Fiber ◽  
Inhibitory Input ◽  
Deep Cerebellar Nuclei

The inferior olive (IO) is composed of electrically-coupled neurons that make climbing fiber synapses onto Purkinje cells. Neurons in different IO subnuclei are inhibited by synapses with wide ranging release kinetics. Inhibition can be exclusively synchronous, asynchronous, or a mixture of both. Whether the same boutons, neurons or sources provide these kinetically distinct types of inhibition was not known. We find that in mice the deep cerebellar nuclei (DCN) and vestibular nuclei (VN) are two major sources of inhibition to the IO that are specialized to provide inhibitory input with distinct kinetics. DCN to IO synapses lack fast synaptotagmin isoforms, release neurotransmitter asynchronously, and are exclusively GABAergic. VN to IO synapses contain fast synaptotagmin isoforms, release neurotransmitter synchronously, and are mediated by combined GABAergic and glycinergic transmission. These findings indicate that VN and DCN inhibitory inputs to the IO are suited to control different aspects of IO activity.

scholarly journals Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells

2019 ◽  
Vol 22 (6) ◽  
pp. 950-962 ◽  
Author(s):  
Dimitar Kostadinov ◽  
Maxime Beau ◽  
Marta Blanco-Pozo ◽  
Michael Häusser
Keyword(s):  
Purkinje Cells ◽  
Climbing Fiber ◽  
Cerebellar Purkinje Cells

Altered Calcium Homeostasis in Cerebellar Purkinje Cells of Leaner Mutant Mice

2000 ◽  
Vol 84 (1) ◽  
pp. 513-524 ◽  
Author(s):  
Leonard S. Dove ◽  
Sang-Soep Nahm ◽  
David Murchison ◽  
Louise C. Abbott ◽  
William H. Griffith
Keyword(s):  
Purkinje Cells ◽  
Calcium Homeostasis ◽  
Mutant Mice ◽  
Cerebellar Purkinje Cells
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