Glucocorticoid-mediated effects on metabolism are reversed by targeting 11 beta hydroxysteroid dehydrogenase type 1 in human skeletal muscle

2009 ◽  
Vol 25 (3) ◽  
pp. 250-258 ◽  
Author(s):  
Firoozeh Salehzadeh ◽  
Lubna Al-Khalili ◽  
Sameer S Kulkarni ◽  
Minghan Wang ◽  
Fredrik Lönnqvist ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Hydroxysteroid Dehydrogenase ◽  
Mediated Effects

11β Hydroxysteroid dehydrogenase type 1 is expressed and is biologically active in human skeletal muscle

2006 ◽  
Vol 65 (6) ◽  
pp. 800-805 ◽  
Author(s):  
Christina Jang ◽  
Varuni R. Obeyesekere ◽  
Rodney J. Dilley ◽  
Frank P. Alford ◽  
Warrick J. Inder
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Hydroxysteroid Dehydrogenase ◽  
Biologically Active

scholarly journals 11 -Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle

Diabetes ◽  
2009 ◽  
Vol 58 (11) ◽  
pp. 2506-2515 ◽  
Author(s):  
S. A. Morgan ◽  
M. Sherlock ◽  
L. L. Gathercole ◽  
G. G. Lavery ◽  
C. Lenaghan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Hydroxysteroid Dehydrogenase

scholarly journals Hexose-6-Phosphate Dehydrogenase Contributes to Skeletal Muscle Homeostasis Independent of 11β-Hydroxysteroid Dehydrogenase Type 1

Endocrinology ◽  
2011 ◽  
Vol 152 (1) ◽  
pp. 93-102 ◽  
Author(s):  
Nina M. Semjonous ◽  
Mark Sherlock ◽  
Pancharatnam Jeyasuria ◽  
Keith L. Parker ◽  
Elizabeth A. Walker ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Hydroxysteroid Dehydrogenase ◽  
Muscle Homeostasis

Treatment of Normal Skeletal Muscle with FK506 or Rapamycin Results in Halothane-induced Muscle Contracture

1998 ◽  
Vol 89 (3) ◽  
pp. 693-698. ◽  
Author(s):  
Richard L. Brooksbank ◽  
Margaret E. Badenhorts ◽  
Hyam Isaacs ◽  
Nerina Savage
Keyword(s):  
Carbon Dioxide ◽  
Skeletal Muscle ◽  
Malignant Hyperthermia ◽  
Ryanodine Receptor ◽  
Human Skeletal Muscle ◽  
Receptor Type ◽  
Muscle Strip ◽  
Healthy Human ◽  
Healthy Persons

Background FKBP12 is a protein that is closely associated with the ryanodine receptor type 1 of skeletal muscle and modulates Ca2+ release by the channel. The immunosuppressants FK506 and rapamycin both bind to FKBP12 and in turn dissociate the protein from the ryanodine receptor. By treating healthy human skeletal muscle strips with FK506 or rapamycin and then subjecting the strips to the caffeine-halothane contracture test, this study determined that FK506 and rapamycin alter the sensitivity of the muscle strip to halothane, caffeine, or both. Methods Skeletal muscle strips from 10 healthy persons were incubated in Krebs medium equilibrated with a 95% oxygen and 5% carbon dioxide mixture, which contained either 12 microM FK506 (n = 8) or 12 microM rapamycin (n = 6), for 15 min at 37 degrees C. The strips were subjected to the caffeine-halothane contracture test for malignant hyperthermia according to the European Malignant Hyperthermia Group protocol. Results Treatment of normal skeletal muscle strips with FK506 and rapamycin resulted in halothane-induced contractures of 0.44+/-0.16 g and 0.6+/-0.49 g, respectively, at 2% halothane. Conclusions The results obtained show that pre-exposure of healthy skeletal muscle strips to either FK506 or rapamycin is sufficient to give rise to halothane-induced contractures. This is most likely caused by destabilization of Ca2+ release by the ryanodine receptor as a result of the dissociation of FKBP12. This finding suggests that a mutation in FKBP12 or changes in its capacity to bind to the ryanodine receptor could alter the halothane sensitivity of the skeletal muscle ryanodine receptor and thereby predispose the person to malignant hyperthermia.

scholarly journals Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle

Diabetologia ◽  
2008 ◽  
Vol 52 (4) ◽  
pp. 664-674 ◽  
Author(s):  
K. Eckardt ◽  
H. Sell ◽  
A. Taube ◽  
M. Koenen ◽  
B. Platzbecker ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Human Skeletal Muscle Cells

Caveolae-mediated effects of TNF-α on human skeletal muscle cells

2018 ◽  
Vol 370 (2) ◽  
pp. 623-631 ◽  
Author(s):  
Elise Dargelos ◽  
Valentine Renaud ◽  
Marion Decossas ◽  
Corinne Bure ◽  
Olivier Lambert ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Mediated Effects ◽  
Human Skeletal Muscle Cells ◽  
Tnf Α

scholarly journals Bioengineered in vitro 3D model of myotonic dystrophy type 1 human skeletal muscle

2021 ◽  
Author(s):  
Xiomara Fernández-Garibay ◽  
María A. Ortega ◽  
Estefanía Cerro-Herreros ◽  
Jordi Comelles ◽  
Elena Martínez ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myotonic Dystrophy ◽  
Human Skeletal Muscle ◽  
3D Model ◽  
Myotonic Dystrophy Type 1 ◽  
Myotonic Dystrophy Type
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