scholarly journals Risk factors in V-shaped risk associations with all-cause mortality in type 2 diabetes—The Hong Kong Diabetes Registry

2008 ◽  
Vol 24 (3) ◽  
pp. 238-246 ◽  
Author(s):  
Wing Yee So ◽  
Xilin Yang ◽  
Ronald C. W. Ma ◽  
Alice P. S. Kong ◽  
Christopher W. K. Lam ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Hong Kong ◽  
Diabetes Registry ◽  
All Cause Mortality

Use of sulphonylurea and cancer in type 2 diabetes—The Hong Kong Diabetes Registry

2010 ◽  
Vol 90 (3) ◽  
pp. 343-351 ◽  
Author(s):  
Xilin Yang ◽  
Wing Yee So ◽  
Ronald C.W. Ma ◽  
Linda W.Y. Yu ◽  
Gary T.C. Ko ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Hong Kong ◽  
Diabetes Registry

408Albuminuria as a predictor of incident ischemic stroke and myocardial infarction in patients with type 2 diabetes but without cardiovascular disease: A Danish cohort study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M V Fangel ◽  
P B Nielsen ◽  
J K Kristensen ◽  
T B Larsen ◽  
T F Overvad ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Cohort Study ◽  
Ischemic Stroke ◽  
Cardiovascular Risk ◽  
All Cause Mortality ◽  
Patients With Diabetes

Abstract Background Risk stratification in patients with type 2 diabetes continues to be an important priority in the management of diabetes-related morbidity and mortality. International guidelines generally recognize patients with diabetes and cardiovascular disease as high-risk patients. Risk stratification is, however, more uncertain in diabetes patients without cardiovascular disease. Micro- and macroalbuminuria have previously been identified as predictors of cardiovascular events and mortality in general cohorts of diabetes patients. However, less is known about the predictive value of albuminuria in patients with diabetes but without established cardiovascular disease. Purpose We aimed to examine the association between albuminuria level and the risk of ischemic stroke, myocardial infarction, and all-cause mortality in patients with type 2 diabetes and without a diagnosis of cardiovascular disease. Methods We linked Danish nationwide registries to identify patients with type 2 diabetes and without cardiovascular disease from May 2005 through June 2015. Based on two consecutive measurements of the urinary albumin excretion rate or albumin-to-creatinine ratio patients were stratified in categories of normoalbuminuria, microalbuminuria, and macroalbuminuria. Patients were followed for the outcomes ischemic stroke, myocardial infarction, and all-cause mortality until December 31, 2015. Five-year risk of outcomes were presented as cumulative incidence functions (with death as a competing event). Associations between albuminuria level and incidence of ischemic stroke, myocardial infarction, and all-cause mortality were evaluated with Cox proportional hazard regression adjusted for cardiovascular risk factors. Results The study population included 78,841 patients with type 2 diabetes (44.7% females, mean age 63.2). When comparing patients with microalbuminuria to patients with normoalbuminuria in an age- and sex-adjusted analysis, we found hazard ratios (HRs) of 1.45 (95% CI: 1.24–1.69), 1.45 (95% CI: 1.24–1.70), and 1.50 (95% CI: 1.39–1.61) for ischemic stroke, myocardial infarction, and all-cause mortality, respectively. Furthermore, macroalbuminuria was associated with HRs of 2.05 (95% CI: 1.70–2.48), 2.25 (95% CI: 1.86–2.71), and 2.03 (95% CI: 1.85–2.23) for ischemic stroke, myocardial infarction, and all-cause mortality, respectively. Similar results were found after adjusting for cardiovascular risk factors. Conclusions In this nationwide cohort study of patients with type 2 diabetes but without cardiovascular disease, patients with micro- and macroalbuminuria had a higher risk of incident ischemic stroke, myocardial infarction, and all-cause mortality. This finding supports that patients with micro- or macroalbuminuria should be screened regularly and followed closely in clinical practice. Moreover, these findings suggest that patients with type 2 diabetes and micro- or macroalbuminuria may benefit from intensive vascular risk reduction.

scholarly journals Target Values of Cardiovascular Risk Factors Are Not Associated with All-Cause Mortality in Patients with Type 2 Diabetes Mellitus

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0124536 ◽  
Author(s):  
Antonio Pacilli ◽  
Olga Lamacchia ◽  
Andrea Fontana ◽  
Massimiliano Copetti ◽  
Mauro Cignarelli ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Target Values ◽  
All Cause Mortality

scholarly journals Effects of albuminuria and renal dysfunction on development of dyslipidaemia in type 2 diabetes--the Hong Kong Diabetes Registry

2008 ◽  
Vol 23 (9) ◽  
pp. 2834-2840 ◽  
Author(s):  
X. Yang ◽  
W. Y. So ◽  
R. Ma ◽  
G. Ko ◽  
A. Kong ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Hong Kong ◽  
Renal Dysfunction ◽  
Diabetes Registry
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