Effect of heat shock protein peptide DiaPep277 on ß-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: two prospective, randomized, double-blind phase II trials

2007 ◽  
Vol 23 (4) ◽  
pp. 276-285 ◽  
Author(s):  
Nanette C. Schloot ◽  
Guido Meierhoff ◽  
Csaba Lengyel ◽  
Gyözö Vándorfi ◽  
József Takács ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Phase Ii ◽  
Cell Function ◽  
Diabetes Mellitus Type 1 ◽  
Phase Ii Trials ◽  
Double Blind ◽  
Recent Onset

β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial

The Lancet ◽  
2001 ◽  
Vol 358 (9295) ◽  
pp. 1749-1753 ◽  
Author(s):  
Itamar Raz ◽  
Dana Elias ◽  
Ann Avron ◽  
Merana Tamir ◽  
Muriel Metzger ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Function ◽  
Phase Ii Trial ◽  
Β Cell ◽  
Double Blind ◽  
Β Cell Function ◽  
New Onset

scholarly journals Exercise to preserve β-cell function in recent-onset Type 1 diabetes mellitus (EXTOD) - a randomized controlled pilot trial

2017 ◽  
Vol 34 (11) ◽  
pp. 1521-1531 ◽  
Author(s):  
P. Narendran ◽  
N. Jackson ◽  
A. Daley ◽  
D. Thompson ◽  
K. Stokes ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Cell Function ◽  
Pilot Trial ◽  
Β Cell ◽  
Recent Onset ◽  
Randomized Controlled ◽  
Β Cell Function

scholarly journals A rationally designed peptide IA-2-P2 against type 1 diabetes in streptozotocin-induced diabetic mice

2017 ◽  
Vol 14 (3) ◽  
pp. 184-190 ◽  
Author(s):  
Lili Shen ◽  
Shiping Lu ◽  
Dongcheng Huang ◽  
Guoliang Li ◽  
Kunfeng Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Type 1 Diabetes Mellitus ◽  
Rabbit Model ◽  
Immunological Tolerance ◽  
Heat Shock Protein 60 ◽  
P2 Peptide

Recent studies have investigated the potential of type 1 diabetes mellitus–related autoantigens, such as heat shock protein 60, to induce immunological tolerance or to suppress the immune response. A functional 24-residue peptide derived from heat shock protein 60 (P277) has shown anti-type 1 diabetes mellitus potential in experimental animals and in clinical studies, but it also carries a potential atherogenic effect. In this study, we have modified P277 to retain an anti-type 1 diabetes mellitus effect and minimize the atherogenic potential by replacing the P277 B epitope with another diabetes-associated autoantigen, insulinoma antigen-2 (IA-2), to create the fusion peptide IA-2-P2. In streptozotocin-induced diabetic C57BL/6J mice, the IA-2-P2 peptide displayed similar anti-diabetic effects to the control P277 peptide. Also, the IA-2-P2 peptide did not show atherogenic activity in a rabbit model. Our findings indicate the potential of IA-2-P2 as a promising vaccine against type 1 diabetes mellitus.

scholarly journals Higher urine heat shock protein 70/creatinine ratio in type 1 diabetes mellitus

Renal Failure ◽  
2016 ◽  
Vol 38 (3) ◽  
pp. 404-410 ◽  
Author(s):  
Alev Yilmaz ◽  
Asuman Gedikbasi ◽  
Zeynep Yuruk Yildirim ◽  
Cemile Pehlivanoglu ◽  
Basak Seker ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Type 1 Diabetes Mellitus ◽  
Heat Shock Protein 70 ◽  
Creatinine Ratio
Sign in / Sign up

Export Citation Format

Share Document