Effects of chronic hyperglycaemia on incident stroke in Hong Kong Chinese patients with type 2 diabetes

2007 ◽  
Vol 23 (3) ◽  
pp. 220-226 ◽  
Author(s):  
Xilin Yang ◽  
Alice P. S. Kong ◽  
Wing Yee So ◽  
Ronald C. W. Ma ◽  
Chung Shun Ho ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Hong Kong ◽  
Hong Kong Chinese ◽  
Chinese Patients ◽  
Chronic Hyperglycaemia

scholarly journals End-stage renal disease risk equations for Hong Kong Chinese patients with type 2 diabetes: Hong Kong Diabetes Registry

Diabetologia ◽  
2006 ◽  
Vol 49 (10) ◽  
pp. 2299-2308 ◽  
Author(s):  
X. L. Yang ◽  
W. Y. So ◽  
A. P. S. Kong ◽  
P. Clarke ◽  
C. S. Ho ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Hong Kong ◽  
End Stage Renal Disease ◽  
Disease Risk ◽  
Hong Kong Chinese ◽  
Chinese Patients ◽  
Diabetes Registry ◽  
Stage Renal Disease ◽  
End Stage

Genetic variants and lipid traits in the Hong Kong Chinese patients with type 2 diabetes

2016 ◽  
Vol 252 ◽  
pp. e148
Author(s):  
M. Hu ◽  
C. Tam ◽  
W.Y. So ◽  
J. Chan ◽  
B. Tomlinson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Hong Kong ◽  
Genetic Variants ◽  
Hong Kong Chinese ◽  
Chinese Patients

Associations between insomnia and glycemic control in Hong Kong Chinese patients with type 2 diabetes

2016 ◽  
Vol 120 ◽  
pp. S158
Author(s):  
Chenzhao Ding ◽  
Eric Siu Him Lau ◽  
Andrea On Yan Luk ◽  
Theresa Yeung ◽  
Wai Sze Chan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Hong Kong ◽  
Glycemic Control ◽  
Hong Kong Chinese ◽  
Chinese Patients

scholarly journals Shortened Relative Leukocyte Telomere Length is Associated with Prevalent and Incident Cardiovascular Complications in Type 2 Diabetes- Analysis from the Hong Kong Diabetes Register

2020 ◽  
Author(s):  
Feifei Cheng ◽  
Andrea O Luk ◽  
Claudia HT Tam ◽  
Baoqi Fan ◽  
Hongjiang Wu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Hong Kong ◽  
Telomere Length ◽  
Cox Regression ◽  
Quantitative Polymerase Chain Reaction ◽  
Hazard Ratio ◽  
Chinese Patients ◽  
Diabetes Register

<b>Objective</b>: Several studies support potential links between leukocyte relative telomere length (rLTL), a biomarker of biological aging and type 2 diabetes. This study investigates relationships between rLTL and subsequent cardiovascular disease (CVD) in patients with type 2 diabetes. <p><b>Research design and methods</b>: Consecutive Chinese patients with type 2 diabetes (N=5349) from the Hong Kong Diabetes Register with stored baseline DNA and available follow-up data were studied. rLTL was measured using quantitative polymerase chain reaction. CVD was diagnosed based on ICD-9 code.</p> <p><b>Results: </b>Mean (SD) follow-up was 13.4(5.5) years. rLTL was correlated inversely with age, diabetes duration, blood pressure, HbA<sub>1c</sub>, urine ACR and positively with eGFR (all P<0.001). Subjects with versus without CVD at baseline had shorter rLTL (4.3±1.2 vs. 4.6±1.2, P<0.001). Of the 4541 CVD-free subjects at baseline, the 1140 who developed CVD during follow-up had shorter rLTL than those remaining CVD-free after adjusting for age, sex, smoking and albuminuria status (4.3±1.2 vs. 4.7±1.2, P<0.001). In Cox regression models, shorter rLTL was associated with higher risk of incident CVD (hazard ratio (95% CI) for each unit decrease: 1.252 (1.195-1.311), P<0.001), which remained significant after adjusting for age, sex, BMI, SBP, LDL-C, HbA<sub>1c</sub>, eGFR and ACR (hazard ratio (95% CI): 1.141 (1.084-1.200), P<0.001).</p> <p><b>Conclusions: </b>rLTL is significantly shorter in type 2 diabetes patients with CVD, is associated with cardiometabolic risk factors, and is independently associated with incident CVD. Telomere length may be a useful biomarker for CVD risk in type 2 diabetes.</p> <b><br> </b>

scholarly journals Replication and Identification of Novel Variants at TCF7L2 Associated with Type 2 Diabetes in Hong Kong Chinese

2007 ◽  
Vol 92 (9) ◽  
pp. 3733-3737 ◽  
Author(s):  
Maggie C. Y. Ng ◽  
Claudia H. T. Tam ◽  
Vincent K. L. Lam ◽  
Wing-Yee So ◽  
Ronald C. W. Ma ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Hong Kong ◽  
Population Attributable Risk ◽  
Control Sample ◽  
Causal Variant ◽  
Case Control ◽  
Hong Kong Chinese ◽  
Nucleotide Polymorphisms ◽  
Risk Alleles

Abstract Objective: Variations at a large linkage disequilibrium (LD) block of transcription factor 7-like 2 gene (TCF7L2) were reported to be associated with type 2 diabetes (T2D) in Icelandic, Danish and European-American populations and further replicated in other populations of European, African, and Asian ancestries. However, data for Chinese and comprehensive survey of the whole gene are lacking. Design: We attempted to examine 22 tagging single-nucleotide polymorphisms (SNPs) spanning across the TCF7L2 gene for association with T2D in Hong Kong Chinese. We first studied a case-control sample involving 433 hospital cases with familial early-onset T2D and 419 normal controls and further studied the associated SNPs in 450 members of 142 diabetic families. Results: Two of the previously reported risk alleles at rs11196205 (C) and rs7903146 (T) were rare in Chinese (0.013 and 0.024, respectively, in controls). Rs11196205 was associated with T2D [odds ratio (OR) [95% confidence interval (CI)] = 2.11 (1.04–4.26)], whereas the association for rs7903146 [OR (95% CI) = 1.27 (0.71–2.29)] was not significant in the case-control sample. Interestingly, another SNP (rs11196218 G allele) located in adjacent LD block conferred independent risk for T2D [OR (95%CI) =1.43 (1.14–1.79)] and contributed high-population attributable risk of 42%. The association finding of rs11196218 and its haplotype for T2D was also replicated in the family sample (P &lt; 0.05). Conclusions: Our results are consistent with others’ findings that variations at TCF7L2 contribute to T2D, including Chinese. The presence of association signals spanning several LD blocks warrants further examination of extended regions to reveal the causal variant(s) for this important T2D gene.

scholarly journals Factors Predicting the Age When Type 2 Diabetes Is Diagnosed in Hong Kong Chinese Subjects

Diabetes Care ◽  
2001 ◽  
Vol 24 (4) ◽  
pp. 646-649 ◽  
Author(s):  
S. C. Lee ◽  
G. T.C. Ko ◽  
J. K.Y. Li ◽  
C. C. Chow ◽  
V. T.F. Yeung ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Hong Kong ◽  
Hong Kong Chinese ◽  
Chinese Subjects
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