Liraglutide combined with human umbilical cord mesenchymal stem cell transplantation inhibits beta‐cell apoptosis via mediating the ASK1/JNK/BAX pathway in rats with type 2 diabetes

2019 ◽  
Vol 36 (2) ◽  
Author(s):  
Wei Wang ◽  
Rong Dan Wu ◽  
Pin Chen ◽  
Xiang Jin Xu ◽  
Xiao Zhi Shi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Beta Cell ◽  
Cell Apoptosis ◽  
Beta Cell Apoptosis ◽  
Human Umbilical Cord ◽  
Mesenchymal Stem Cell Transplantation

scholarly journals THE ROLE OF SURVIVIN AND RAF-1 KINASE AGAINST ENHANCEMENT OF PANCREATIC BETA-CELL APOPTOSIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

2018 ◽  
Vol 11 (11) ◽  
pp. 344
Author(s):  
Eva Decroli ◽  
Asman Manaf ◽  
Syafril Syahbuddin ◽  
Sarwono Waspadji ◽  
Dwisari Dillasamola
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Beta Cell ◽  
Cell Apoptosis ◽  
Pancreatic Beta Cell ◽  
Enzyme Linked Immunosorbent Assay ◽  
Beta Cell Apoptosis

Objective: This study aimed to reveal differences in levels of survivin and Raf-1 kinase in prediabetes, controlled Type 2 diabetes mellitus (T2DM), uncontrolled T2DM, and their relationship with hemoglobin A1c (HbA1c) levels and serum triglyceride levels.Methods: This study was an observational study with a cross-sectional design. The study involved 60 people with T2DM who visited the endocrine and metabolic clinic and 30 prediabetes patients. The variables were survivin levels and Raf-1 kinase enzymes that examined using enzyme-linked immunosorbent assay techniques. HbA1c values are measured by high-performance liquid chromatography and triglyceride levels measured by enzymatic method.Results: Average levels of Raf-1 kinase were significantly higher in the prediabetes group, controlled T2DM, and uncontrolled T2DM (11.6±1.4 pg mL, 9.9±1.1 pg/mL, and 9.1±1.5 pg/mL). Survivin was significantly higher in the prediabetes group, controlled T2DM, and uncontrolled T2DM (5.4±0.4 pg mL, 5.0±0.2 pg/mL, and 4.7±0.1 pg/mL). There was no correlation between HbA1c with Raf-1 kinase levels (R=−0.215, p=0.250), but there was a correlation between HbA1c with serum survivin levels (R=−0.6, *p<0.05). There was a correlation between the levels of triglycerides with survivin but not with Raf-1 kinase (R=−0.267, *p=0.039).Conclusion: Survivin and Raf-1 kinase levels are lower in uncontrolled T2DM. This explained the role of survivin and Raf-1 kinase against enhancement of pancreatic beta-cell apoptosis in patients with T2DM.

Hypercaloric diet contribues to beta cell apoptosis in type 2 diabetes

2019 ◽  
Vol 27 (3) ◽  
pp. 217-220 ◽  
Author(s):  
D Miricescu ◽  
AMA Stanescu ◽  
H Lazarescu ◽  
A Kozma ◽  
A Totan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Beta Cell ◽  
Cell Apoptosis ◽  
Beta Cell Apoptosis ◽  
Hypercaloric Diet

scholarly journals GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

PLoS Genetics ◽  
2013 ◽  
Vol 9 (5) ◽  
pp. e1003532 ◽  
Author(s):  
Tatiane C. Nogueira ◽  
Flavia M. Paula ◽  
Olatz Villate ◽  
Maikel L. Colli ◽  
Rodrigo F. Moura ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Beta Cell ◽  
Cell Apoptosis ◽  
Splice Variant ◽  
Pancreatic Beta Cell ◽  
Susceptibility Gene ◽  
Beta Cell Apoptosis
Sign in / Sign up

Export Citation Format

Share Document