Low vitamin D is associated with diabetes peripheral neuropathy in older but not in young and middle‐aged patients

2019 ◽  
Vol 35 (6) ◽  
Author(s):  
Yang Niu ◽  
Ji Li ◽  
Rongxia Peng ◽  
Xuelin Zhao ◽  
Jiang Wu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Peripheral Neuropathy ◽  
Middle Aged ◽  
Aged Patients ◽  
Diabetes Peripheral Neuropathy

Vitamin D levels in middle-aged patients with obstructive sleep apnoea syndrome

2017 ◽  
Vol 40 ◽  
pp. e104
Author(s):  
K. Archontogeorgis ◽  
E. Nena ◽  
A. Galanou ◽  
A. Zissimopoulos ◽  
D. Siopi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Middle Aged ◽  
Aged Patients ◽  
Sleep Apnoea Syndrome ◽  
Obstructive Sleep ◽  
Vitamin D Levels

Vitamin D Levels in Middle-Aged Patients with Obstructive Sleep Apnoea Syndrome

2018 ◽  
Vol 16 (3) ◽  
pp. 289-297 ◽  
Author(s):  
K. Archontogeorgis ◽  
E. Nena ◽  
N. Papanas ◽  
A. Zissimopoulos ◽  
A. Voulgaris ◽  
...  
Keyword(s):  
Vitamin D ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Middle Aged ◽  
Aged Patients ◽  
Sleep Apnoea Syndrome ◽  
Obstructive Sleep ◽  
Vitamin D Levels

scholarly journals A Retrospective Analysis of Pain Etiology in Middle-Aged Patients with Peripheral Neuropathy

Medicina ◽  
2021 ◽  
Vol 57 (8) ◽  
pp. 787
Author(s):  
Anna K. Szewczyk ◽  
Anna Jamroz-Wiśniewska ◽  
Konrad Rejdak
Keyword(s):  
Peripheral Neuropathy ◽  
Electrophysiological Study ◽  
Middle Aged ◽  
Aged Patients ◽  
Small Fibre Neuropathy ◽  
Aged People ◽  
Small Fibre ◽  
Laboratory Results ◽  
And Gender ◽  
Internal And External Factors

Background and Objectives: Correct assessment and a multidisciplinary approach appear to be extremely important in preventing peripheral neuropathy and its complications. The purpose of this study was to find the correlations and dissimilarities between different types of peripheral neuropathy, the occurrence of pain, and laboratory results. Materials and Methods: This retrospective study assessed 124 patients who were hospitalized in our neurology department due to various types of sensory or motor disturbances. The patients were eventually diagnosed with peripheral neuropathy, based on the electrophysiological study, anamnesis, physical examination, and laboratory results. The whole group was subjected to statistical analysis. Results: The mean age of patients was over 56 years, with a slight woman predominance. A statistically significant (p < 0.05) relationship between the place of residence and gender was seen, where more men than women live in the rural area, while more women than men live in the urban area. Most often we observed symmetric, sensorimotor, demyelinating, inflammatory, and chronic neuropathy. More than 40% of patients reported pain. A statistically significant correlation between the evolution/severity and the occurrence of pain was seen in subacute type (p < 0.05) and small fibre neuropathy (p < 0.01). Conclusions: A higher incidence of peripheral neuropathy in middle-aged people will become essential in the aging society with lifestyle and chronic disorders. Peripheral neuropathy is slightly more common in women than men and its occurrence may be influenced by work performed or internal and external factors. In the study group, more than 40% of patients reported pain, therefore the pain measurement for each patient should be implemented and repeated at every visit. An assessment of sodium level and, in women, markers of neuroinflammation level in the various types of peripheral neuropathy may be an interesting direction for the future.

scholarly journals Vitamin D Deficiency in Patients with Diabetic Peripheral Neuropathy

2019 ◽  
Vol 7 (4) ◽  
pp. 291-294
Author(s):  
Hameedullah Khan ◽  
Ihsanullah Rajar ◽  
Abdul Rauf Memon ◽  
Nadeem Naeem
Keyword(s):  
Vitamin D ◽  
Peripheral Neuropathy ◽  
Diabetic Neuropathy ◽  
Vitamin D Deficiency ◽  
Diabetic Peripheral Neuropathy ◽  
Cross Sectional Study ◽  
Key Words Diabetes ◽  
Cross Sectional ◽  
Peripheral Diabetic Neuropathy ◽  
Diabetes Peripheral Neuropathy

Objective: To determine the frequency of vitamin D deficiency in patients presenting with diabetic peripheral neuropathyPatients and Methods: This cross sectional study was carried out in Department of Medicine and Neurology Indus Medical College, Tando Muhammad khan. from March 2017 to August 2017. Total 74 cases of Diabetes Mellitus presenting with peripheral diabetic neuropathy were selected for the study. Evolution of degree of Neuropathy was based on TCSS score as: {no neuropathy: ≤5, severe: ≥12, moderate: 9-11 and mild: 6-8}. Vitamin D level was categorized as (deficiency (0-20 ng/ml), insufficiency (21-30 ng/ml) sufficiency (>30 ng/ml), excess (>50 ng/ml) and toxicity (>100 ng/ml). All the data was entered in SPSS.Results: Total 74 patients with diabetic neuropathy were studied. Vast majority of patients 36(48.6%) were found in age group 51-60 years, Majority were males 45(60.8%). Most of the cases 35(47.3%) were with 1-3 years duration of neuropathy. Majority of patients 42(56.8%) were found with Mild peripheral neuropathy. Vitamin-D deficiency was present in 2(43.2%) cases and insufficiency was observed in 27(36.5%) cases. No significant association was found between vitamin D deficiency and severity of neuropathy.Conclusion: Vitamin D deficiency was found (43.2%) in patients of diabetic peripheral neuropathy. Vitamin screening and intake of supplement is necessary, will help to decrease the complication of peripheral neuropathy in Diabetic cases. Key words: Diabetes, Peripheral neuropathy, Vitamin D

Dyslipidemia and hyperglycemia predict coronary heart disease events in middle-aged patients with NIDDM

Diabetes ◽  
1997 ◽  
Vol 46 (8) ◽  
pp. 1354-1359 ◽  
Author(s):  
S. Lehto ◽  
T. Ronnemaa ◽  
S. M. Haffner ◽  
K. Pyorala ◽  
V. Kallio ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Middle Aged ◽  
Aged Patients

Long Term Clinical and Echocardiographic Outcomes in Middle Aged Patients Undergoing the Ross Procedure

2019 ◽  
Vol 3 (sup1) ◽  
pp. 53-53
Author(s):  
Jamie Romeo ◽  
Grigorios Papageorgiou ◽  
Francisco da Costa ◽  
Hans Sievers ◽  
Ad Bogers ◽  
...  
Keyword(s):  
Ross Procedure ◽  
Middle Aged ◽  
Aged Patients

scholarly journals Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jing Xiao ◽  
Jingyi Lv ◽  
Shiyu Wang ◽  
Yang Zhou ◽  
Lunwen Chen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Mendelian Randomization ◽  
Middle Aged ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Randomization Analysis

Abstract Background Vitamin D deficiency has been associated with type 2 diabetes (T2D) and metabolic syndrome (MS) and its components. However, it is unclear whether a low concentration of vitamin D is the cause or consequence of these health conditions. Thus, this study aimed to evaluate the association of vitamin D concentrations and its genetic risk scores (GRSs) with MS and its component diseases, such as T2D, in middle-aged and elderly participants from rural eastern China. Methods A subset of 2393 middle-aged and elderly individuals were selected from 70,458 participants of the Nantong Chronic Diseases Study of 2017–2018 in China. We used two 25-hydroxyvitamin D (25[OH]D) synthesis single-nucleotide polymorphisms (SNPs) (DHCR7-rs12785878 and CYP2R1-rs10741657) and two 25(OH) D metabolism SNPs (GC-rs2282679 and CYP24A1-rs6013897) for creating GRSs, which were used as instrumental variables to assess the effect of genetically lowered 25(OH) D concentrations on MS and T2D based on the Wald ratio. F statistics were used to validate that the four SNPs genetically determined 25(OH) D concentrations. Results Compared to vitamin D sufficient individuals, individuals with vitamin D insufficiency had an odds ratio (OR [95% confidence interval {CI}]) of MS of 1.30 (1.06–1.61) and of T2D of 1.32 (1.08–1.64), individuals with vitamin D deficiency had an ORs (95% CI) of MS of 1.50 (1.24–1.79) and of T2D of 1.47 (1.12–1.80), and those with vitamin D severe deficiency had an ORs (95% CI) of MS of 1.52 (1.29–1.85) and of T2D of 1.54 (1.27–1.85). Mendelian randomization analysis showed a 25-nmol/L decrease in genetically instrumented serum 25(OH) D concentrations using the two synthesis SNPs (DHCR7 and CYP2R1 genes) associated with the risk of T2D and abnormal diastolic blood pressure (DBP) with ORs of 1.10 (95%CI: 1.02–1.45) for T2D and 1.14 (95%CI: 1.03–1.43) for DBP. Conclusions This one sample Mendelian randomization analysis shows genetic evidence for a causal role of lower 25(OH) D concentrations in promoting of T2D and abnormal DBP in middle-aged and elderly participants from rural China.

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