scholarly journals Early-onset type 2 diabetes: Age gradient in clinical and behavioural risk factors in 5115 persons with newly diagnosed type 2 diabetes-Results from the DD2 study

2017 ◽  
Vol 34 (3) ◽  
pp. e2968 ◽  
Author(s):  
A. Bo ◽  
R.W. Thomsen ◽  
J.S. Nielsen ◽  
S.K. Nicolaisen ◽  
H. Beck-Nielsen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Early Onset ◽  
Newly Diagnosed ◽  
Onset Type ◽  
Behavioural Risk Factors

Risk of Incident Heart Failure in Individuals With Early-Onset Type 2 Diabetes

2021 ◽  
Author(s):  
Jian-Jun Liu ◽  
Sylvia Liu ◽  
Jiexun Wang ◽  
Janus Lee ◽  
Justin I-Shing Tang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Type 2 Diabetes ◽  
Early Onset ◽  
Absolute Risk ◽  
Diabetes Duration ◽  
Adjusted Relative Risk ◽  
Onset Type ◽  
Onset Diabetes

Abstract Context Early-onset diabetes has been associated with unfavorable cardiovascular risk but data on heart failure (HF) in this subpopulation are scarce. Objective We aimed to study the risk of, and risk factors for, incident HF in individuals with early-onset type 2 diabetes. Methods We studied 606 individuals with type 2 diabetes diagnosed before 40 years of age (early-onset) and 1258 counterparts with diabetes diagnosed from 41 to 65 years of age (usual-onset) with no HF history, at a regional hospital, over a median follow-up period of 7.1 years. Incident HF by European Cardiology Society criteria was determined. Results A total of 62 and 108 HF events were identified in the early- and usual-onset groups (1.55 and 1.29 per 100 patient-years), respectively. Compared with usual-onset counterparts, individuals with early-onset diabetes had a 1.20-fold unadjusted (95% CI, 0.88-1.63; P = 0.26) and 1.91-fold age-adjusted (95% CI, 1.37-2.66; P < 0.001) hazard ratio (HR) for incident HF. Adjustment for traditional cardiometabolic risk factors only moderately mitigated the hazards (adjusted HR 1.69; 95% CI, 1.19-2.40; P = 0.003). However, additional adjustment for estimated glomerular filtration rate and albuminuria markedly attenuated the association of early-onset age with incident HF (adjusted HR 1.24; 95% CI, 0.87-1.77; P = 0.24). Notably, a long diabetes duration was not significantly associated with HF risk after accounting for kidney measures. Conclusion Individuals with early-onset diabetes have at least the same absolute risk and a 2-fold age-adjusted relative risk for incident HF. Excess cardiorenal risk factors but not a long diabetes duration are main drivers for HF development in this diabetic population.

P28 Early onset type 2 diabetes and associated risk factors

2014 ◽  
Vol 103 ◽  
pp. S40-S41
Author(s):  
G. Kiraka ◽  
N. Kunyiha ◽  
P. Ojwang ◽  
R. Easmus
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Early Onset ◽  
Onset Type ◽  
Associated Risk Factors

Vitamin D concentrations from neonatal dried blood spots and the risk of early-onset type 2 diabetes in the Danish D-tect case-cohort study

Diabetologia ◽  
2021 ◽  
Author(s):  
Amélie Keller ◽  
Fanney Thorsteinsdottir ◽  
Maria Stougaard ◽  
Isabel Cardoso ◽  
Peder Frederiksen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Cohort Study ◽  
Early Onset ◽  
Dried Blood Spots ◽  
Onset Type ◽  
Blood Spots

scholarly journals Missense mutations in theTGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes

2007 ◽  
Vol 28 (11) ◽  
pp. 1150-1150 ◽  
Author(s):  
O. Porzio ◽  
O. Massa ◽  
V. Cunsolo ◽  
C. Colombo ◽  
M. Malaponti ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Transglutaminase 2 ◽  
Missense Mutations ◽  
Gene Encoding ◽  
Onset Type

scholarly journals Preliminary analysis of immune activation in early onset type 2 diabetes

2013 ◽  
Vol 72 (1) ◽  
pp. 21190 ◽  
Author(s):  
Julia D. Rempel ◽  
Juliet Packiasamy ◽  
Heather J. Dean ◽  
Jonathon McGavock ◽  
Alyssa Janke ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Immune Activation ◽  
Early Onset ◽  
Preliminary Analysis ◽  
Onset Type
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