Gluten-free diet increases beta-cell volume and improves glucose tolerance in an animal model of type 2 diabetes

2016 ◽  
Vol 32 (7) ◽  
pp. 675-684 ◽  
Author(s):  
Martin Haupt-Jorgensen ◽  
Karsten Buschard ◽  
Axel K. Hansen ◽  
Knud Josefsen ◽  
Julie Christine Antvorskov
Keyword(s):  
Type 2 Diabetes ◽  
Animal Model ◽  
Glucose Tolerance ◽  
Beta Cell ◽  
Cell Volume ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Beta Cell Volume

Synergistic Effects of Long-Term Combination Therapy of DPP-4 Inhibitor and SGLT2 Inhibitor on the Preservation of Beta-Cell Volume in Rats with Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2132-P
Author(s):  
HIROKI MIZUKAMI ◽  
DANYANG GUO ◽  
KAZUHISA TAKAHASHI ◽  
SHO OSONOI ◽  
SAORI OGASAWARA ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Combination Therapy ◽  
Beta Cell ◽  
Cell Volume ◽  
Synergistic Effects ◽  
Sglt2 Inhibitor ◽  
Beta Cell Volume

2127-P: Reduced Islet Parasympathetic Nerve Density Correlates with Decrease in Beta-Cell Volume of Islet in Lean Type 2 Diabetic Goto-Kakizaki Rat

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2127-P
Author(s):  
HIROKI MIZUKAMI ◽  
DANYANG GUO ◽  
KAZUHISA TAKAHASHI ◽  
SHO OSONOI ◽  
KAZUHIRO KUDO ◽  
...  
Keyword(s):  
Beta Cell ◽  
Cell Volume ◽  
Parasympathetic Nerve ◽  
Beta Cell Volume ◽  
Type 2 Diabetic

MG53 marks poor beta cell performance and predicts onset of type 2 diabetes in subjects with different degrees of glucose tolerance.

2021 ◽  
pp. 101292
Author(s):  
Cristina Bianchi ◽  
Francesco Raggi ◽  
Chiara Rossi ◽  
Simona Frontoni ◽  
Riccardo C. Bonadonna ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Beta Cell ◽  
Cell Performance

scholarly journals Enhanced Glucose Tolerance and Pancreatic Beta Cell Function by Low Dose Aspirin in Hyperglycemic Insulin-Resistant Type 2 Diabetic Goto-Kakizaki (GK) Rats

2015 ◽  
Vol 36 (5) ◽  
pp. 1939-1950 ◽  
Author(s):  
Layla Amiri ◽  
Annie John ◽  
Jasmin Shafarin ◽  
Ernest Adeghate ◽  
Petrilla Jayaprakash ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Beta Cell ◽  
Energy Utilization ◽  
Gk Rats ◽  
Insulin Resistant ◽  
Glucose Ingestion ◽  
Anti Inflammatory ◽  
Prevention Of Diabetes

Background/Aim: Type 2 diabetes is the most common metabolic disorder, characterized by insulin resistance and pancreatic islet beta-cell failure. The most common complications associated with type 2 diabetes are hyperinsulinemia, hyperglycemia, hyperlipidemia, increased inflammatory and reduced insulin response. Aspirin (ASA) and other non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with the prevention of diabetes, obesity and related cardiovascular disorders. Aspirin has been used in many clinical and experimental trials for the prevention of diabetes and associated complications. Methods: In this study, five month old Goto-Kakizaki (GK) rats, which showed signs of mild hyperglycemia (fasting blood glucose 80-95 mg/dl vs 55-60 mg/dl Wistar control rats) were used. Two subgroups of GK and Wistar control rats were injected intraperitoneally with 100 mg aspirin/kg body weight/ day for 5 weeks. Animals were sacrificed and blood and tissues were collected after performing glucose tolerance (2 h post 2g IP glucose ingestion) tests in experimental and control groups. Results: Aspirin caused a moderate decrease in hyperglycemia. However, we observed a significant improvement in glucose tolerance after ASA treatment in GK rats compared to the nondiabetic Wistar rats. Also, the ASA treated GK rats exhibited a significant decrease in insulinemia. ASA treatment also caused a marked reduction in the pro-inflammatory prostaglandin, PGE2, which was significantly higher in GK rats. On the other hand, no significant organ toxicity was observed after ASA treatment at this dose and time period. However, the total cholesterol and lipoprotein levels were significantly increased in GK rats, which decreased after ASA treatment. Immunofluorescence staining for insulin/glucagon secreting pancreatic cells showed improved beta-cell structural and functional integrity in ASA-treated rats which was also confirmed by SDS-PAGE and Western blot analysis. Conclusion: The improved glucose tolerance in ASA-treated GK rats may be associated with increased insulin responses due to the anti-inflammatory properties of ASA and enhanced nitric oxide (NO) level which facilitated insulin signaling and energy utilization in target tissues. These results may have implications in determining the therapeutic use of ASA in insulin-resistant type 2 diabetes.

Interaction between genetic and dietary factors determines beta-cell function in Psammomys obesus, an animal model of type 2 diabetes

Diabetes ◽  
1999 ◽  
Vol 48 (4) ◽  
pp. 731-737 ◽  
Author(s):  
R. Nesher ◽  
D. J. Gross ◽  
M. Y. Donath ◽  
E. Cerasi ◽  
N. Kaiser
Keyword(s):  
Type 2 Diabetes ◽  
Animal Model ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Dietary Factors ◽  
Psammomys Obesus
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