Autocrine C-peptide mechanism underlying INS1 beta cell adaptation to oxidative stress

2014 ◽  
Vol 30 (7) ◽  
pp. 599-609 ◽  
Author(s):  
Patrizia Luppi ◽  
Peter Drain
Keyword(s):  
Oxidative Stress ◽  
Beta Cell ◽  
C Peptide ◽  
Cell Adaptation ◽  
Beta Cell Adaptation

scholarly journals Incretin Receptor Null Mice Reveal Key Role of GLP-1 but Not GIP in Pancreatic Beta Cell Adaptation to Pregnancy

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e96863 ◽  
Author(s):  
R. Charlotte Moffett ◽  
Srividya Vasu ◽  
Bernard Thorens ◽  
Daniel J. Drucker ◽  
Peter R. Flatt
Keyword(s):  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Cell Adaptation ◽  
Beta Cell Adaptation

scholarly journals Molecular Mechanisms of Beta Cell Adaptation to Hyperlipidemia

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Mason C. Poffenbarger ◽  
Daniel R. Lathen ◽  
H. Austin Ricks ◽  
Andrew M. Barlow ◽  
Zoey F. Roth ◽  
...  
Keyword(s):  
Beta Cell ◽  
Molecular Mechanisms ◽  
Cell Adaptation ◽  
Beta Cell Adaptation

scholarly journals Ethnic differences in beta cell adaptation to insulin resistance in obese children and adolescents

Diabetologia ◽  
2006 ◽  
Vol 49 (3) ◽  
pp. 571-579 ◽  
Author(s):  
R. Weiss ◽  
J. D. Dziura ◽  
T. S. Burgert ◽  
S. E. Taksali ◽  
W. V. Tamborlane ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Beta Cell ◽  
Children And Adolescents ◽  
Ethnic Differences ◽  
Obese Children ◽  
Cell Adaptation ◽  
Beta Cell Adaptation

scholarly journals KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response

Cell Reports ◽  
2016 ◽  
Vol 15 (5) ◽  
pp. 1051-1061 ◽  
Author(s):  
Nabil Rabhi ◽  
Pierre-Damien Denechaud ◽  
Xavier Gromada ◽  
Sarah Anissa Hannou ◽  
Hongbo Zhang ◽  
...  
Keyword(s):  
Beta Cell ◽  
Unfolded Protein Response ◽  
Pancreatic Beta Cell ◽  
Metabolic Stress ◽  
Cell Adaptation ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response ◽  
Beta Cell Adaptation

Diminished arginine-stimulated insulin secretion in trained men

1990 ◽  
Vol 69 (1) ◽  
pp. 261-267 ◽  
Author(s):  
F. Dela ◽  
K. J. Mikines ◽  
B. Tronier ◽  
H. Galbo
Keyword(s):  
Growth Hormone ◽  
Insulin Secretion ◽  
Beta Cell ◽  
Insulin Response ◽  
Cell Secretion ◽  
Cell Adaptation ◽  
Glucose Stimulated Insulin Secretion ◽  
Beta Hydroxybutyrate ◽  
Beta Cell Adaptation ◽  
Beta Cell Secretion

Glucose-stimulated insulin secretion is depressed by training. To further elucidate the beta-cell adaptation to training, a nonglucose secretagogue was applied. Arginine was infused for 90 min to seven trained and seven untrained young men. Arginine and glucose concentrations increased identically in the groups. The insulin response was biphasic and waned despite increasing arginine concentrations. Both these phases as well as C-peptide responses were reduced in trained subjects, whereas proinsulin responses were similar in the groups. Identical increases were found in glucagon, growth hormone, catecholamines, and production and disappearance of glucose; identical decreases were found in free fatty acids, glycerol, and beta-hydroxybutyrate. In conclusion, in men training diminishes both arginine- and glucose-stimulated insulin secretion, indicating a profound beta-cell adaptation. Being enhanced, the effects of insulin on both production and disposal of glucose are changed in the opposite direction to beta-cell secretion by training. The responses of glucagon- and growth hormone-secreting cells to arginine do not change with training.

scholarly journals Topologically Heterogeneous Beta Cell Adaptation in Response to High-Fat Diet in Mice

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56922 ◽  
Author(s):  
Johanne H. Ellenbroek ◽  
Hendrica A. Töns ◽  
Natascha de Graaf ◽  
Cindy J. Loomans ◽  
Marten A. Engelse ◽  
...  
Keyword(s):  
Beta Cell ◽  
High Fat Diet ◽  
High Fat ◽  
Cell Adaptation ◽  
Beta Cell Adaptation
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