Prevalence and fate of type 1 diabetes-associated autoantibodies in cord blood samples from newborn infants of non-diabetic mothers

2001 ◽  
Vol 18 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Anu-Maaria Hämäläinen ◽  
Jorma Ilonen ◽  
Olli Simell ◽  
Kaisa Savola ◽  
Petri Kulmala ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cord Blood ◽  
Newborn Infants ◽  
Blood Samples ◽  
Diabetic Mothers

scholarly journals Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes

Biomolecules ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 33 ◽  
Author(s):  
Santosh Lamichhane ◽  
Linda Ahonen ◽  
Thomas Sparholt Dyrlund ◽  
Alex M. Dickens ◽  
Heli Siljander ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cord Blood ◽  
Characteristic Curve ◽  
Newborn Infants ◽  
Study Groups ◽  
Islet Autoimmunity ◽  
Molecular Profile ◽  
Islet Autoantibody ◽  
Risk Of Progression

Previous studies suggest that children who progress to type 1 diabetes (T1D) later in life already have an altered serum lipid molecular profile at birth. Here, we compared cord blood lipidome across the three study groups: children who progressed to T1D (PT1D; n = 30), children who developed at least one islet autoantibody but did not progress to T1D during the follow-up (P1Ab; n = 33), and their age-matched controls (CTR; n = 38). We found that phospholipids, specifically sphingomyelins, were lower in T1D progressors when compared to P1Ab and the CTR. Cholesterol esters remained higher in PT1D when compared to other groups. A signature comprising five lipids was predictive of the risk of progression to T1D, with an area under the receiver operating characteristic curve (AUROC) of 0.83. Our findings provide further evidence that the lipidomic profiles of newborn infants who progress to T1D later in life are different from lipidomic profiles in P1Ab and CTR.

scholarly journals Umbilical Cord Blood DNA Methylation in Children Who Later Develop Type 1 Diabetes

2021 ◽  
Author(s):  
Essi Laajala ◽  
Ubaid Ullah ◽  
Toni Grönroos ◽  
Omid Rasool ◽  
Viivi Halla-aho ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Type 1 Diabetes ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Reduced Representation ◽  
Prediction And Prevention ◽  
Develop Type ◽  
Methylation Patterns

Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine, whether perinatal DNA methylation could be associated with later progression to type 1 diabetes. Reduced representation bisulfite sequencing (RRBS) analysis was performed on umbilical cord blood samples collected within the Type 1 Diabetes Prediction and Prevention (DIPP) study. Children later diagnosed with type 1 diabetes and/or testing positive for multiple islet autoantibodies (N=43) were compared to control individuals (N=79), who remained autoantibody-negative throughout the DIPP follow-up until 15 years of age. Potential confounding factors related to the pregnancy and the mother were included in the analysis. No differences in the cord blood methylation patterns were observed between these cases and controls.

scholarly journals Prediction of type 1 diabetes at birth: cord blood metabolites versus genetic risk score in the MoBa cohort

2021 ◽  
Author(s):  
German Tapia ◽  
Tommi Suvitaival ◽  
Linda Ahonen ◽  
Nicolai A Lund-Blix ◽  
Pål R Njølstad ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cord Blood ◽  
Bile Acids ◽  
Risk Score ◽  
Genetic Risk ◽  
Risk Group ◽  
Genetic Risk Score ◽  
Blood Concentrations ◽  
Polar Metabolites

Abstract Background and aim Genetic markers are established as predictive of type 1 diabetes, but unknown early life environment is believed to be involved. Umbilical cord blood may reflect perinatal metabolism and exposures. We studied whether selected polar metabolites in cord blood contribute to prediction of type 1 diabetes. Methods Using a targeted UHPLC-QQQ-MS platform, we quantified 27 low molecular weight metabolites (including amino acids, small organic acids and bile acids) in 166 children, who later developed type 1 diabetes, and 177 random control children in the Norwegian Mother, Father and Child (MoBa) cohort. We analysed the data using logistic regression (estimating odds ratios per standard deviation [aOR]), area under the receiver operating characteristic curve (AUC) and k-means clustering. Metabolites were compared to a genetic risk score based on 51 established non-HLA SNPs, and a four-category HLA risk group. Results The strongest associations for metabolites were aminoadipic acid (aOR=1.23,95%CI:0.97–1.55), indoxyl sulfate (aOR=1.15,95%CI:0.87–1.51), and tryptophan (aOR=0.84,95%CI:0.65–1.10), with other aORs close to 1.0, and none significantly associated with type 1 diabetes. K-means clustering identified six clusters, none of which were associated with type 1 diabetes. Cross-validated AUC showed no predictive value of metabolites (AUC 0.49), while the non-HLA genetic risk score AUC was 0.56 and the HLA risk group AUC was 0.78. Conclusions In this large study, we found no support of a predictive role of cord blood concentrations of selected bile acids and other small polar metabolites in the development of type 1 diabetes.

ALPHA1-FETOPROTEIN AND CARBONIC ANHYDRASE B AND C CONCENTRATION IN CORD BLOOD FROM NEWBORN INFANTS OF DIABETIC MOTHERS

1974 ◽  
Vol 77 (3_Suppl) ◽  
pp. S81-S86 ◽  
Author(s):  
B. Nørgaard-Pedersen ◽  
J. G. Klebe
Keyword(s):  
Carbonic Anhydrase ◽  
Cord Blood ◽  
Gestational Age ◽  
Newborn Infants ◽  
Infants Of Diabetic Mothers ◽  
Carbonic Anhydrase B ◽  
Erythrocyte Carbonic Anhydrase ◽  
Diabetic Mothers

ABSTRACT Erythrocyte carbonic anhydrase (CA) concentration B and C and the α1-fetoprotein (AFP) concentration was determined in cord blood from 45 newborn infants of diabetic mothers (IDM). The concentration of these quantities has separately been compared with the corresponding concentration in cord blood from normal newborn infants with the same gestational age. No difference was found except for AFP, where a significantly (P < 0.05) higher concentration was found in some infants of insulin treated diabetic mothers.

scholarly journals Insulin-Like Growth Factor-1 at Diagnosis and during Subsequent Years in Adolescents with Type 1 Diabetes

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Simona I. Chisalita ◽  
J. Ludvigsson
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Secretion ◽  
Insulin Treatment ◽  
Insulin Dose ◽  
Newly Diagnosed ◽  
Blood Samples ◽  
C Peptide ◽  
Endogenous Insulin ◽  
High Hba1c

Background. Type 1 diabetes (T1D) in adolescents is associated with alterations in the insulin-like factor system probably caused both by a deranged metabolism and insulinopenia in the portal vein. Objective. To study how the circulating IGF-1 is affected at diagnosis and during subsequent years in adolescents with T1D. Methods. Ten girls and ten boys with type 1 diabetes (T1D), aged 13.0 ± 1.4 (mean ± SD) years at diagnosis, took part in the study. Blood samples were drawn at diagnosis and after 3, 9, 18, and 48 months. HbA1c, total IGF-1, and C-peptide were measured. Results. At diagnosis, the patients had high HbA1c, low IGF-1, and measurable C-peptide. After the start of insulin treatment, maximal improvement in glycemic control and IGF-1 occurred within 3 months and then both tended to deteriorate, that is, HbA1c to increase and IGF-1 to decrease. C-peptide decreased with time, and after 4 years, half of the patients were C-peptide negative. At diagnosis, C-peptide correlated positively to IGF-1 (r=0.50; p<0.03). C-peptide correlated negatively with insulin dose (U/kg) after 18 and 48 months from diagnosis (r=−0.48; p<0.03 and r=−0.72; p<0.001, resp.). Conclusions. In conclusion, our results show that in newly diagnosed adolescents with type 1 diabetes and deranged metabolism, the IGF-1 level is low and rapidly improves with insulin treatment but later tends to decrease concomitantly with declining endogenous insulin secretion.

Effect of a single autologous cord blood infusion on beta-cell and immune function in children with new onset type 1 diabetes: a non-randomized, controlled trial

2013 ◽  
Vol 15 (2) ◽  
pp. 100-109 ◽  
Author(s):  
Eleni Z Giannopoulou ◽  
Ramona Puff ◽  
Andreas Beyerlein ◽  
Irene von Luettichau ◽  
Heike Boerschmann ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Type 1 Diabetes ◽  
Beta Cell ◽  
Cord Blood ◽  
Immune Function ◽  
Controlled Trial ◽  
Onset Type ◽  
Randomized Controlled ◽  
New Onset

Enterovirus RNA in longitudinal blood samples and risk of islet autoimmunity in children with a high genetic risk of type 1 diabetes: the MIDIA study

Diabetologia ◽  
2014 ◽  
Vol 57 (10) ◽  
pp. 2193-2200 ◽  
Author(s):  
Ondrej Cinek ◽  
Lars C. Stene ◽  
Lenka Kramna ◽  
German Tapia ◽  
Sami Oikarinen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Genetic Risk ◽  
Islet Autoimmunity ◽  
Blood Samples ◽  
High Genetic Risk

scholarly journals Maternal microchimerism in cord blood and risk of childhood‐onset type 1 diabetes

2019 ◽  
Author(s):  
German Tapia ◽  
Georgina Mortimer ◽  
Jody Ye ◽  
Benjamin Thomas Gillard ◽  
Saranna Chipper‐Keating ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cord Blood ◽  
Childhood Onset ◽  
Onset Type
Sign in / Sign up

Export Citation Format

Share Document