Microvascular dysfunction in diabetic foot disease and ulceration

2009 ◽  
Vol 25 (7) ◽  
pp. 604-614 ◽  
Author(s):  
Clare Y. L. Chao ◽  
Gladys L. Y. Cheing
Keyword(s):  
Diabetic Foot ◽  
Microvascular Dysfunction ◽  
Diabetic Foot Disease ◽  
Foot Disease

Current Concepts in Diabetic Microvascular Dysfunction

2006 ◽  
Vol 96 (3) ◽  
pp. 245-252 ◽  
Author(s):  
Javier La Fontaine ◽  
Lawrence B. Harkless ◽  
Christian E. Davis ◽  
Marque A. Allen ◽  
Paula K. Shireman
Keyword(s):  
Diabetic Foot ◽  
Vascular System ◽  
Microvascular Dysfunction ◽  
Diabetic Macroangiopathy ◽  
Patients With Diabetes ◽  
Foot Problems ◽  
Control Of Diabetes ◽  
Diabetic Foot Disease ◽  
Foot Disease ◽  
Pathologic Processes

Microvascular dysfunction is an important component of the pathologic processes that occur in diabetic foot disease. The endothelial abnormalities observed in patients with diabetes mellitus are poorly understood, and evidence suggests that endothelial dysfunction could be involved in the pathogenesis of diabetic macroangiopathy and microangiopathy. With the advent of insulin replacement in the early 1900s and increased efforts toward metabolic control of diabetes, long-term complications of this disease have become apparent. These late-term complications are primarily disorders of the vascular system. This article reviews the process of microvascular dysfunction and how it may relate to the pathogenesis of diabetic foot problems. (J Am Podiatr Med Assoc 96(3): 245–252, 2006)

Critical limb ischaemia in diabetes: definition, assessment, prognosis

VASA ◽  
2001 ◽  
Vol 30 (Supplement 58) ◽  
pp. 21-27
Author(s):  
Luther
Keyword(s):  
Diabetic Foot ◽  
Laboratory Tests ◽  
Critical Limb Ischaemia ◽  
Limb Ischaemia ◽  
Clinical Use ◽  
Arterial Reconstruction ◽  
Arterial Circulation ◽  
Diabetic Foot Disease ◽  
Foot Disease ◽  
Fontaine Classification

In diabetic foot disease, critical limb ischaemia (CLI) cannot be precisely described using established definitions. For clinical use, the Fontaine classification complemented with any objective verification of a reduced arterial circulation is sufficient for decision making. For scientific purposes, objective measurement criteria should be reported. Assessment of CLI should rely on the physical examination of the limb arteries, complemented by laboratory tests like the shape of the PVR curve at ankle or toe levels, and arteriography. The prognosis of CLI in diabetic foot disease depends on the success of arterial reconstruction. The best prognosis for the patients is with a preserved limb. Reconstructive surgery is the best choice for the majority of patients.

scholarly journals Association of anaemia in patients with diabetic foot disease

2012 ◽  
Vol 10 (8) ◽  
pp. S105
Author(s):  
Mustafa Khanbhai ◽  
Stavros Loukogeorgakis ◽  
Steven Hurel ◽  
Richards Toby
Keyword(s):  
Diabetic Foot ◽  
Diabetic Foot Disease ◽  
Foot Disease

Association Between the Diabetes mellitus Duration and the Severity of Diabetic Foot Disease in Hospitalized Patients in Latin America

2021 ◽  
pp. 153473462110632
Author(s):  
Belissa Bedriñana-Marañón ◽  
Maria Rubio-Rodríguez ◽  
Marlon Yovera-Aldana ◽  
Eilhart Garcia-Villasante ◽  
Isabel Pinedo-Torres
Keyword(s):  
Diabetes Mellitus ◽  
Latin America ◽  
Diabetic Foot ◽  
Poisson Regression ◽  
Hospitalized Patients ◽  
Bivariate Analysis ◽  
Severe Injuries ◽  
History Of ◽  
Diabetic Foot Disease ◽  
Foot Disease

The objective was to determine the association between a diabetes mellitus duration greater than 10 years and the severity of diabetic foot in hospitalized patients in Latin America. Analytical, observational, and retrospective study based in secondary databases. Patients older than 18 years with diagnosis of diabetes mellitus (DM) and hospitalized for any causes were included. The independent and dependent variables were having more than 10 years of diagnosis of DM and the severity of the diabetic foot disease (Wagner> = 2), respectively. A crude Poisson regression analysis was performed to obtain prevalence rates adjusted to confounders. Male gender was 54.8% and the median age was 62 years. In the group with more than10 years of disease (n = 903) 18% (n = 162) had severe injuries. We performed two Poisson regression analyzes, one of which included the entire sample; and in the other, only patients with some degree of ulcer were included at the time of evaluation (Wagner > = 1). In the first analysis the PR was 1.95 ( p < 0.01) adjusted for the significant variables in the bivariate analysis and in the second analysis the PR was 1.18 ( p < 0.01) adding to the adjustment the days of injury prior to hospitalization and the location of the ulcer. We conclude that in patients with more than 10 years of diabetes mellitus, diabetic foot injuries are more severe, regardless type of diabetes, gender, age, history of amputation and days of injury prior to hospitalization for inpatients in Latin America.

A STUDY ON THE ROLE OF EPIDERMAL GROWTH FACTOR IN DIABETIC ULCER MANAGEMENT

2021 ◽  
pp. 62-63
Author(s):  
R. Rani Suganya ◽  
M. Annapoorani ◽  
C. Naveen Kumar
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Diabetic Foot ◽  
Diabetic Ulcer ◽  
Epidermal Growth Factor Treatment ◽  
Epidermal Growth ◽  
Diabetic Foot Disease ◽  
Foot Disease

Diabetes mellitus is a disease of large magnitude with 25 million people affected by the disease in India. One of the common complications of this disease is Diabetic foot disease characterised by non-healing ulcers over the foot predominantly. This study is aimed at evaluating the efcacy and tolerability of Recombinant Epidermal Growth Factor treatment in increasing the rate of healing of ulcers and decreasing the duration of ulcer healing among patients with diabetic foot disease thereby improving the quality of life, preventing further morbidity and mortality and shortening hospital stay.

The personal cost of diabetic foot disease in the developing world-a study from Pakistan

2008 ◽  
Vol 25 (10) ◽  
pp. 1231-1233 ◽  
Author(s):  
S. M. Ali ◽  
A. Fareed ◽  
S. M. Humail ◽  
A. Basit ◽  
M. Y. Ahmedani ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Developing World ◽  
Personal Cost ◽  
Diabetic Foot Disease ◽  
Foot Disease
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