Beta cell function in the preclinical period of insulin-dependent diabetes

1987 ◽  
Vol 3 (1) ◽  
pp. 27-43 ◽  
Author(s):  
David K. McCulloch ◽  
Jerry P. Palmer ◽  
Edward A. Benson
Keyword(s):  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Insulin Dependent Diabetes ◽  
Insulin Dependent

Residual Pancreatic Beta-Cell Function in Insulin-Dependent Diabetes Mellitus

1987 ◽  
Vol 29 (3) ◽  
pp. 408-413
Author(s):  
Shin Amemiya ◽  
Kohsuke Higashida ◽  
Masatoshi Fujimoto ◽  
Kohtaro Asayama ◽  
Kazuyoshi Ichimura ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Pancreatic Beta Cell ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent ◽  
Pancreatic Beta Cell Function

Beta-cell function and diabetic control in insulin dependent diabetes melletus

1985 ◽  
Vol 110 (4_Suppl) ◽  
pp. S73-S77 ◽  
Author(s):  
Ole K. Faber
Keyword(s):  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Secretory Activity ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Diabetic Patients ◽  
C Peptide ◽  
Key Words Insulin ◽  
Insulin Dependent

Abstract. Beta-cell function, as evaluated from plasma C-peptide measurements, is found in all insulin dependent diabetic patients the first months of disease and in about 15% of patients with more than 15 years of treatment. The beta-cells are capable of modulating their secretory activity in response to changes in blood glucose. Even a minimal residual insulin secretion is of metabolic significance. Key words: insulin dependent diabetes mellitus, beta-cell function, C-peptide metabolic control.

Pancreatic hormone secretion in chronic pancreatitis without residual beta-cell function

1988 ◽  
Vol 118 (3) ◽  
pp. 357-364 ◽  
Author(s):  
S. Larsen ◽  
J. Hilsted ◽  
B. Tronier ◽  
H. Worning
Keyword(s):  
Chronic Pancreatitis ◽  
Beta Cell ◽  
Pancreatic Polypeptide ◽  
Beta Cell Function ◽  
Cell Function ◽  
Insulin Dependent Diabetes ◽  
Type I ◽  
Mixed Meal ◽  
Pancreatic Glucagon ◽  
Insulin Dependent

Abstract. Hormonal responses (glucagon, pancreatic polypeptide and somatostatin) to iv glucagon, iv arginine, and ingestion of a mixed meal were investigated in 6 patients with insulin-dependent diabetes secondary to chronic pancreatitis without beta-cell function, in 8 Type I (insulin-dependent) diabetics without beta-cell function, and 8 healthy subjects. No significant differences were found between the two diabetic groups regarding glucagon responses to arginine and meal ingestion. In the patients with diabetes secondary to chronic pancreatitis compared with Type I diabetics and normal controls, the pancreatic polypeptide concentrations were significantly lower and somatostatin concentrations were significantly higher after glucagon, arginine and a mixed meal. Thus, pancreatic glucagon secretion was preserved in patients with insulin-dependent diabetes secondary to chronic pancreatitis, having no residual beta-cell function. These findings suggest that pancreatic glucagon deficiency is not absolute in insulin-dependent diabetes secondary to chronic pancreatitis. A high level of somatostatin may contribute to a lower blood glucose level in patients with chronic pancreatitis.

Beta Cell Function in Insulin-Treated Non-Insulin-Dependent Diabetic Patients

Pancreas ◽  
1986 ◽  
Vol 1 (5) ◽  
pp. 411-414
Author(s):  
Ambady Ramachandran ◽  
Chamukuttan Snehalatha ◽  
Viswanathan Mohan ◽  
Appa Rao ◽  
Moopil Viswanathan
Keyword(s):  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Diabetic Patients ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic
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