Long-term effects of prenatal stress on HPA axis activity in juvenile rhesus monkeys

1994 ◽  
Vol 27 (5) ◽  
pp. 257-269 ◽  
Author(s):  
A. S. Clarke ◽  
D. J. Wittwer ◽  
D. H. Abbott ◽  
M. L. Schneider
Keyword(s):  
Hpa Axis ◽  
Prenatal Stress ◽  
Rhesus Monkeys ◽  
Long Term Effects ◽  
Hpa Axis Activity

scholarly journals Antenatal Corticosteroids: A Risk Factor for the Development of Chronic Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Elizabeth Asztalos
Keyword(s):  
Preterm Birth ◽  
Hpa Axis ◽  
Animal Studies ◽  
Fetal Lung ◽  
Later Life ◽  
Long Term Effects ◽  
Antenatal Corticosteroids ◽  
Fetal Maturity ◽  
Hpa Axis Activity

Preterm birth remains a major health issue worldwide. Since the 1990s, women at risk for preterm birth received a single course of exogenous antenatal corticosteroids (ACSs) to facilitate fetal lung maturity. More recently, repeated or multiple courses of ACS have been supported to provide continued fetal maturity support for women with continued risk of preterm birth. However, exogenous ACS reduces birth weight which, in turn, is associated with adverse adult outcomes such as coronary heart disease, stroke, hypertension, and type 2 diabetes. The long-term effects of ACS exposure on HPA axis activity and neurological function are well documented in animal studies, and it appears that ACS, regardless of dose exposure, is capable of affecting fetal HPA axis development causing permanent changes in the HPA axis that persists through life and is manifested by chronic illness and behavioral changes. The challenge in human studies is to demonstrate whether an intervention such as ACS administration in pregnancy contributes to developmental programming and how this is manifested in later life.

scholarly journals Effects of sex and early maternal abuse on adrenocorticotropin hormone and cortisol responses to the corticotropin-releasing hormone challenge during the first 3 years of life in group-living rhesus monkeys

2010 ◽  
Vol 22 (1) ◽  
pp. 45-53 ◽  
Author(s):  
Mar M. Sanchez ◽  
Kai Mccormack ◽  
Alison P. Grand ◽  
Richelle Fulks ◽  
Anne Graff ◽  
...  
Keyword(s):  
Sex Differences ◽  
Hpa Axis ◽  
Rhesus Monkeys ◽  
Group Living ◽  
Cortisol Response ◽  
Corticotropin Releasing Hormone ◽  
Long Term Effects ◽  
Releasing Hormone ◽  
Cortisol Responses

AbstractIn this study we investigated the development of the hypothalamic–pituitary–adrenal (HPA) axis in 21 group-living rhesus monkeys infants that were physically abused by their mothers in the first few months of life and in 21 nonabused controls. Cortisol and adrenocorticotropin hormone (ACTH) responses to a corticotropin-releasing hormone (CRH) challenge were assessed at 6-month intervals during the subjects' first 3 years of life. Abused infants exhibited greater cortisol responses to CRH than controls across the 3 years. Abused infants also exhibited blunted ACTH secretion in response to CRH, especially at 6 months of age. Although there were no significant sex differences in abuse experienced early in life, females showed a greater cortisol response to CRH than males at all ages. There were no significant sex differences in the ACTH response to CRH, or significant interactions between sex and abuse in the ACTH or cortisol response. Our findings suggest that early parental maltreatment results in greater adrenocortical, and possibly also pituitary, responsiveness to challenges later in life. These long-term alterations in neuroendocrine function may be one the mechanisms through which infant abuse results in later psychopathologies. Our study also suggests that there are developmental sex differences in adrenal function that occur irrespective of early stressful experience. The results of this study can enhance our understanding of the long-term effects of child maltreatment as well as our knowledge of the development of the HPA axis in human and nonhuman primates.

scholarly journals Gender differences in the long-term effects of chronic prenatal stress on the HPA axis and hypothalamic structure in rats

2010 ◽  
Vol 35 (10) ◽  
pp. 1525-1535 ◽  
Author(s):  
Cristina García-Cáceres ◽  
Natalia Lagunas ◽  
Isabel Calmarza-Font ◽  
Iñigo Azcoitia ◽  
Yolanda Diz-Chaves ◽  
...  
Keyword(s):  
Gender Differences ◽  
Hpa Axis ◽  
Prenatal Stress ◽  
Long Term Effects ◽  
Hypothalamic Structure

LONG TERM EFFECTS OF VASECTOMY ON EXPERIMENTAL ATHEROSCLEROSIS IN RHESUS MONKEYS

1986 ◽  
Vol 64 (6) ◽  
pp. 527-533 ◽  
Author(s):  
Neelam Bansal ◽  
S Majumdar ◽  
NK Ganguly ◽  
RN Chakravarti
Keyword(s):  
Rhesus Monkeys ◽  
Experimental Atherosclerosis ◽  
Long Term Effects

New Insights into Prenatal Stress: Immediate- and Long-Term Effects on the Fetus and Their Timing

Neonatal Pain ◽  
2017 ◽  
pp. 75-85
Author(s):  
Kieran J. O’Donnell ◽  
Nadja Reissland ◽  
Vivette Glover
Keyword(s):  
Prenatal Stress ◽  
Long Term Effects

Long-term effects of prenatal stress and handling on metabolic parameters: relationship to corticosterone secretion response

1996 ◽  
Vol 712 (2) ◽  
pp. 287-292 ◽  
Author(s):  
Monique Vallée ◽  
Willy Mayo ◽  
Stefania Maccari ◽  
Michel Le Moal ◽  
Hervé Simon
Keyword(s):  
Prenatal Stress ◽  
Metabolic Parameters ◽  
Long Term Effects ◽  
Corticosterone Secretion
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