Behavioral selection of odor cues by young female mice affects age of puberty

1992 ◽  
Vol 25 (6) ◽  
pp. 461-470 ◽  
Author(s):  
Lee C. Drickamer
Keyword(s):  
Young Female ◽  
Behavioral Selection ◽  
Female Mice ◽  
Odor Cues ◽  
Selection Of

scholarly journals Estrogen Receptor β Controls Muscle Growth and Regeneration in Young Female Mice

2020 ◽  
Vol 15 (3) ◽  
pp. 577-586 ◽  
Author(s):  
Daiki Seko ◽  
Ryo Fujita ◽  
Yuriko Kitajima ◽  
Kodai Nakamura ◽  
Yuuki Imai ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Muscle Growth ◽  
Young Female ◽  
Estrogen Receptor Β ◽  
Female Mice

Abstract 3710: Estrogen Does not Account for Accelerated Atherosclerosis in LDLr−/− Mice

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Victoria L King ◽  
Nicholas Hatch ◽  
Xuan Zhang ◽  
Lisa R Tannock
Keyword(s):  
Body Weight Gain ◽  
Atherosclerotic Lesion ◽  
Young Female ◽  
Lesion Formation ◽  
Accelerated Atherosclerosis ◽  
Female Mice ◽  
Ldl Particles ◽  
Gender Specific Differences ◽  
Event Rates ◽  
Atherosclerotic Lesion Formation

Clinical studies demonstrate less atherosclerosis in pre-menopausal women compared to age-matched men, but an equalization in atherosclerosis burden and cardiovascular event rates between genders following menopause. Conversely, using the LDLR−/− mouse model we and others have previously demonstrated that young female mice develop accelerated atherosclerosis compared to age matched males. Whether this difference is due to sex hormones or differences in metabolic factors is not clear. To determine if estrogen mediated the alterations in atherosclerosis in the female mice, female mice were ovariectomized (Ovx). Ovx mice had a marked reduction in uterus weight (Sham: 86 ± 1 vs Ovx: 26 ± 1mg, P < 0.001) and both Ovx females and males had greater body weight gain when fed a lard-enriched diet (10% kcal from fat, D12451 , Research Diets) for 17 weeks compared to sham females. Ovariectomy resulted in an increase in fasting glucose concentrations, which was comparable to males. Cholesterol and triglyceride concentrations were higher in both sham and Ovx females compared to males; primarily distributed in increased VLDL and LDL particles. Interestingly, ovariectomy had no significant effect on extent of atherosclerotic lesion formation in female mice and the extent of atherosclerotic lesion area in both female groups was significantly increased compared to male mice. These data suggest that gender specific differences in lipids and atherosclerotic lesion formation in female LDL-R deficient mice fed a diet enriched in lard are not mediated by estrogen.

scholarly journals Germ Cell Loss Induced by 12C6+ Ion Irradiation in Young Female Mice

2006 ◽  
Vol 47 (2) ◽  
pp. 131-134 ◽  
Author(s):  
Hong ZHANG ◽  
Xu ZHANG ◽  
Zhigang YUAN ◽  
Xiaoda LI ◽  
Wenjian LI ◽  
...  
Keyword(s):  
Germ Cell ◽  
Ion Irradiation ◽  
Cell Loss ◽  
Young Female ◽  
Female Mice

scholarly journals Cosmetic selection of skin incision for resection of choledochal cyst in young female patients

2016 ◽  
Vol 20 (3) ◽  
pp. 127
Author(s):  
Shin Hwang ◽  
Jong-Woo Choi ◽  
Tae-Yong Ha ◽  
Gi-Won Song ◽  
Dong-Hwan Jung
Keyword(s):  
Choledochal Cyst ◽  
Skin Incision ◽  
Young Female ◽  
Female Patients ◽  
Selection Of

Antral follicle population in prepubertal and pubertal heifers

2019 ◽  
Vol 31 (1) ◽  
pp. 10 ◽  
Author(s):  
M. M. Seneda ◽  
F. Morotti ◽  
A. F. Zangirolamo ◽  
N. C. da Silva ◽  
T. K. Sanches ◽  
...  
Keyword(s):  
Antral Follicle ◽  
Antral Follicle Count ◽  
Young Female ◽  
Reproductive Efficiency ◽  
Young Females ◽  
Antral Follicles ◽  
Female Cattle ◽  
Selection Of

The antral follicle count (AFC) is an important tool in the selection of bovine females destined for biotechnology. However, little is known about AFC in prepubertal and pubertal heifers. Some challenges inherent to the physiology of young females must be considered to achieve efficient rates with different procedures, such as ovum pick-up and IVF. This paper covers some important topics about ovarian physiology related to the population of antral follicles and reproductive efficiency in young female cattle.

scholarly journals Impacts of Aging and Blackcurrant Supplementation on the Gut Microbiome Profile of Female Mice (P20-031-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Sang Gil Lee ◽  
Cao Lei ◽  
Melissa Melough ◽  
Junichi Sakaki ◽  
Kendra Maas ◽  
...  
Keyword(s):  
Relative Abundance ◽  
Gut Microbiome ◽  
Health Benefits ◽  
Alpha Diversity ◽  
Young Female ◽  
Rrna Gene ◽  
Fecal Samples ◽  
Female Mice ◽  
Aged Mice ◽  
Young Mice

Abstract Objectives Blackcurrant, an anthocyanin-rich berry, has multiple health benefits. The purpose of this study was to examine the impacts of blackcurrant supplementation and aging on gut bacterial communities in female mice. Methods Three-month and 18-month old female mice were provided standard chow diets with or without anthocyanin-rich blackcurrant extract (BC) (1% w/w) for four months. Upon study completion, fecal samples were collected directly from the animals’ colons. Microbiome DNA was extracted from the fecal samples and the V3-V4 regions of their 16S rRNA gene were amplified and sequenced using Results Taxonomic analysis showed a significantly decrease in alpha diversity in aged female mice, compared to young counterparts. BC consumption did not alter the alpha diversity in either young or aged mice compared to control diets. For beta diversity, we observed the clustering was associated with age but not diet. The phylogenic abundance analysis showed that the relative abundance of several phyla, including Firmicutes, Bacteroidetes, Cyanobacteria, Proteobacteria, and Tenericutes was higher in aged compared to young mice. Among them, the abundance of Firmicutes was downregulated by BC in the young but not the aged mice. The abundance of Bacteroidetes was increased by BC in both the young and the aged groups. Noticeably, Verrucomicrobia was the only phylum whose relative abundance was upregulated in the aged female mice compared to the young mice. Meanwhile, its relative abundance in the aged group was suppressed by BC. Interestingly, Desulfovibrio, which is the most representative sulfate-reducing genus, was detectable only in young female mice, and BC increased its relative abundance. Conclusions Our results characterized the gut microbiome compositions in young and aged female mice, and indicated that the gut microbiome of young and aged female mice responded differently to four month BC administration. Through additional research, the microbial alterations observed in this study should be further investigated to inform our understanding of the effect of BC on the gut microbiome, the possible health benefits related to these changes, and the differing effects of BC supplementation across populations. Funding Sources This study was supported by the USDA NIFA Seed Grant (#2016-67018-24492) and the University of Connecticut Foundation Esperance Funds to Dr. Ock K. Chun. We thank the National Institute on Aging for providing aged mice for the project and Just the Berries Ltd. for providing the blackcurrant extract.

scholarly journals Changes in Experimental Stroke Outcome across the Life Span

2009 ◽  
Vol 29 (4) ◽  
pp. 792-802 ◽  
Author(s):  
Fudong Liu ◽  
Rongwen Yuan ◽  
Sharon E Benashski ◽  
Louise D McCullough
Keyword(s):  
Life Span ◽  
Cellular Response ◽  
Young Male ◽  
The Elderly ◽  
Young Female ◽  
Artery Occlusion ◽  
Experimental Stroke ◽  
Elderly Age ◽  
Edema Formation ◽  
Female Mice

Acute ischemic stroke is a leading cause of mortality and disability in the elderly. Age is the most important nonmodifiable risk factor for stroke, yet many preclinical models continue to examine only young male animals. It remains unclear how experimental stroke outcomes change with aging and with biologic sex. If sex differences are present, it is not known whether these reflect an intrinsic differing sensitivity to stroke or are secondary to the loss of estrogen with aging. We subjected both young and aging mice of both sexes to middle cerebral artery occlusion (MCAO). Young female mice had smaller strokes compared with age-matched males, an effect that was reversed by ovariectomy. Stroke damage increased with aging in female mice, whereas male mice had decreased damage after MCAO. Blood–brain barrier (BBB) permeability changes are correlated with infarct size. However, aging mice had significantly less edema formation, an effect that was independent of sex and histologic damage. Differences in the cellular response to stroke occur across the life span in both male and female mice. These differences need to be considered when developing relevant therapies for stroke patients, the majority of whom are elderly.

scholarly journals Aging Impairs Reverse Remodeling and Recovery of Ventricular Function after Isoproterenol-Induced Cardiomyopathy

2021 ◽  
Vol 23 (1) ◽  
pp. 174
Author(s):  
Laia Yáñez-Bisbe ◽  
Anna Garcia-Elias ◽  
Marta Tajes ◽  
Isaac Almendros ◽  
Antonio Rodríguez-Sinovas ◽  
...  
Keyword(s):  
Ejection Fraction ◽  
Young Female ◽  
Reverse Remodeling ◽  
Cardiomyocyte Hypertrophy ◽  
Beta Adrenergic ◽  
Tissue Fibrosis ◽  
Reduced Ejection Fraction ◽  
Female Mice ◽  
Collagen Iii ◽  
Isoproterenol Infusion

Information about heart failure with reduced ejection fraction (HFrEF) in women and the potential effects of aging in the female heart is scarce. We investigated the vulnerability to develop HFrEF in female elderly mice compared to young animals, as well as potential differences in reverse remodeling. First, HF was induced by isoproterenol infusion (30 mg/kg/day, 28 days) in young (10-week-old) and elderly (22-month-old) female mice. In a second set of animals, mice underwent isoproterenol infusion followed by no treatment during 28 additional days. Cardiac remodeling was assessed by echocardiography, histology and gene expression of collagen-I and collagen-III. Following isoproterenol infusion, elderly mice developed similar HFrEF features compared to young animals, except for greater cell hypertrophy and tissue fibrosis. After beta-adrenergic withdrawal, young female mice experienced complete reversal of the HFrEF phenotype. Conversely, reversed remodeling was impaired in elderly animals, with no significant recovery of LV ejection fraction, cardiomyocyte hypertrophy and collagen deposition. In conclusion, chronic isoproterenol infusion is a valid HF model for elderly and young female mice and induces a similar HF phenotype in both. Elderly animals, unlike young, show impaired reverse remodeling, with persistent tissue fibrosis and cardiac dysfunction even after beta-adrenergic withdrawal.

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