The effect of early experience on water maze spatial learning and memory in rats

1990 ◽  
Vol 23 (5) ◽  
pp. 427-439 ◽  
Author(s):  
Richard C. Tees ◽  
Kristin Buhrmann ◽  
Jordan Hanley
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Water Maze ◽  
Early Experience ◽  
Spatial Learning And Memory

scholarly journals Hyperthermia-Induced Febrile Seizures Have Moderate and Transient Effects on Spatial Learning in Immature Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Nawel Yagoubi ◽  
Yosra Jomni ◽  
Mohsen Sakly
Keyword(s):  
Learning And Memory ◽  
Morris Water Maze ◽  
Spatial Learning ◽  
Water Maze ◽  
Febrile Seizures ◽  
Hot Water ◽  
Spatial Learning And Memory ◽  
Transient Effects ◽  
Hyperthermia Treatment ◽  
Immature Rats

The aim of this study was to characterize a novel animal model hyperthermia-induced febrile seizure and to investigate the impacts of repetitive febrile seizures on spatial learning and memory performances in immature rats.Methods. Rats were subjected to hyperthermia exposure one, two, or three times in 10-day intervals during 30 min in a water bath warmed at 45–50°C and their behaviour was monitored. Morris water maze spatial learning and memory were examined for control and treated groups. Results showed that rats subjected to 30-minute hyperthermia hot water developed rapidly myoclonic jerks and then generalized seizures. After a single hyperthermia exposure, the time for generalised tonic-clonic seizures appearance was 16.08 ± 0.60 min and it decreased gradually with repetitive exposure to reach 12.46 ± 0.39 min by the third exposure. Febrile seizures altered the spatial learning and memory abilities in Morris water maze and increased the time spent to attain the platform after one or two exposures, while after a third exposure rats exhibited the same latency compared to controls. Similar results were obtained in probe test where rats, subjected to hyperthermia for one or two episodes, spent less time in the target quadrant compared to corresponding controls. Further, when platform was moved from northwest to southwest quadrant, memory transfer test indicated that after one or two hyperthermia exposures cognitive performances were slightly altered, while after a third exposure the latency to escape increased significantly compared to untreated group. It was concluded that 30 min of hyperthermia hot water was sufficient to induce febrile seizures in immature rats and an increase of susceptibility was observed with repetitive hyperthermia exposure. Hyperthermia treatment impaired cognitive performances but the effects were mostly transient and moderate.

Effect of age on the radial arm water maze—a test of spatial learning and memory

2004 ◽  
Vol 25 (2) ◽  
pp. 223-229 ◽  
Author(s):  
Barbara Shukitt-Hale ◽  
John J. McEwen ◽  
Aleksandra Szprengiel ◽  
James A. Joseph
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Water Maze ◽  
Spatial Learning And Memory ◽  
Effect Of Age

Intracranial self-stimulation facilitates a spatial learning and memory task in the Morris water maze

Neuroscience ◽  
2008 ◽  
Vol 154 (2) ◽  
pp. 424-430 ◽  
Author(s):  
J. Ruiz-Medina ◽  
I. Morgado-Bernal ◽  
D. Redolar-Ripoll ◽  
L. Aldavert-Vera ◽  
P. Segura-Torres
Keyword(s):  
Learning And Memory ◽  
Morris Water Maze ◽  
Spatial Learning ◽  
Water Maze ◽  
Memory Task ◽  
Spatial Learning And Memory ◽  
Self Stimulation

scholarly journals Using the Morris Water Maze to Assess Spatial Learning and Memory in Weanling Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0124521 ◽  
Author(s):  
Christopher D. Barnhart ◽  
Dongren Yang ◽  
Pamela J. Lein
Keyword(s):  
Learning And Memory ◽  
Morris Water Maze ◽  
Spatial Learning ◽  
Water Maze ◽  
Spatial Learning And Memory
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