scholarly journals Mouse model of panic disorder: Vulnerability to early environmental instability is strain‐dependent

2021 ◽  
Author(s):  
Alessandra Luchetti ◽  
Matteo Di Segni ◽  
Diego Andolina ◽  
Rossella Ventura ◽  
Marco Battaglia ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Mouse Model ◽  
Environmental Instability ◽  
Strain Dependent ◽  
Is Strain

scholarly journals Azole Heteroresistance in Cryptococcus neoformans: Emergence of Resistant Clones with Chromosomal Disomy in the Mouse Brain during Fluconazole Treatment

2013 ◽  
Vol 57 (10) ◽  
pp. 5127-5130 ◽  
Author(s):  
Edward Sionov ◽  
Yun C. Chang ◽  
Kyung J. Kwon-Chung
Keyword(s):  
Mouse Model ◽  
Cryptococcus Neoformans ◽  
Mouse Brain ◽  
Content Type ◽  
The Brain ◽  
Strain Dependent ◽  
Is Strain

ABSTRACTWe have previously reported thatCryptococcus neoformansstrains are innately heteroresistant to fluconazolein vitro, producing minor, highly resistant subpopulations due to adaptive formation of disomic chromosomes. Using a mouse model, we assessed the emergence of heteroresistant clones in the brain during fluconazole treatment and found that the occurrence of heteroresistant clonesin vivowith chromosomal disomy is strain dependent. Interestingly, emergence of heteroresistant clonesin vivowas unrelated to the strain's MIC to fluconazole.

Intensity of Halothane- and Hypercapnia-Induced Cerebral Hyperemia Is Strain-Dependent in Rats

1996 ◽  
Vol 83 (2) ◽  
pp. 359-365 ◽  
Author(s):  
Hiroshi Takahashi ◽  
Jeffrey R. Kirsch ◽  
Toshiki Okada ◽  
Richard J. Traystman
Keyword(s):  
Strain Dependent ◽  
Is Strain

scholarly journals Microglial—Macrophage Synthesis of Tumor Necrosis Factor after Focal Cerebral Ischemia in Mice is Strain Dependent

2002 ◽  
Vol 22 (7) ◽  
pp. 785-797 ◽  
Author(s):  
Kate Lykke Lambertsen ◽  
Rikke Gregersen ◽  
Bente Finsen
Keyword(s):  
Cerebral Ischemia ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Focal Cerebral Ischemia ◽  
Infarct Volume ◽  
Border Zone ◽  
Mouse Strains ◽  
Strain Dependent ◽  
Necrosis Factor ◽  
Is Strain

Commonly used inbred mouse strains display substantial differences in sensitivity to focal cerebral ischemia. Such differences can often be ascribed to differences in vascular anatomy. The authors investigated whether a contributing factor could be strain-related differences in cellular synthesis of the pleiotropic and potential neurotoxic cytokine tumor necrosis factor (TNF) in the border zone of and within the focal cerebral infarct. In all mouse strains investigated they found that TNF was synthesized by infarct and periinfarct infiltrating Mac-1 immunopositive microglia—macrophages. BALB/c mice, which developed the largest infarcts, contained significantly fewer TNF-producing microglia—macrophages compared with SJL and C57BL/6 mice at both 12 and 24 hours after permanent occlusion of the distal part of the middle cerebral artery. SJL mice developed larger infarcts than C57BL/6 mice, whereas the number of TNF-producing microglia—macrophages per infarct volume unit was comparable. Western blotting data confirmed the increased TNF levels in SJL mice compared with BALB/c and C57BL/6 mice. Furthermore, mice with 12-hour postischemic survival consistently contained two-to threefold more TNF-producing microglia—macrophages than mice with 24-hour survival. The data show that the magnitude of the cellular TNF response to cerebral ischemia is strain dependent, while the time-profile and the cellular sources of TNF are similar irrespective of genetic background. Furthermore, the lack of correlation between infarct size and cellular TNF response suggests that the functionally important TNF is produced in the very early phase (minutes to a few hours) after induction of ischemia, just as it raises the possibility that different mouse strains display different sensitivities to TNF.

The involvement of prostaglandin E2 in interleukin-1β evoked anorexia is strain dependent

2017 ◽  
Vol 60 ◽  
pp. 27-31 ◽  
Author(s):  
Anna Nilsson ◽  
Louise Elander ◽  
Martin Hallbeck ◽  
Unn Örtegren Kugelberg ◽  
David Engblom ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Interleukin 1Β ◽  
Strain Dependent ◽  
Is Strain

Inflammation-induced airway smooth muscle responsiveness is strain dependent in mice

2011 ◽  
Vol 24 (4) ◽  
pp. 361-366 ◽  
Author(s):  
Jesper Säfholm ◽  
Cecilia Lövdahl ◽  
Linda Swedin ◽  
Piet J.M. Boels ◽  
Sven-Erik Dahlén ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Strain Dependent ◽  
Is Strain
Sign in / Sign up

Export Citation Format

Share Document