scholarly journals Extending the developmental origins of disease model: Impact of preconception stress exposure on offspring neurodevelopment

2018 ◽  
Vol 60 (7) ◽  
pp. 753-764 ◽  
Author(s):  
Kate Keenan ◽  
Alison E. Hipwell ◽  
Quetzal A. Class ◽  
Kimberley Mbayiwa
Keyword(s):  
Disease Model ◽  
Developmental Origins ◽  
Stress Exposure ◽  
Developmental Origins Of Disease

Developmental basis of disease: environmental impacts

2011 ◽  
Vol 2 (1) ◽  
pp. 49-55 ◽  
Author(s):  
G. W. Collman
Keyword(s):  
Life Span ◽  
Early Life ◽  
Environmental Chemicals ◽  
Environmental Stressors ◽  
Health Impacts ◽  
Developmental Origins ◽  
Maternal Factors ◽  
Developmental Origins Of Disease ◽  
Conducting Research ◽  
Early Life Exposures

Exposure to environmental chemicals and other environmental stressors have health impacts on the fetus that may not be apparent until later in life. The concept of developmental origins of disease should be expanded to include these early life exposures in addition to the effects of nutrition and maternal factors. This paper will describe the toxicological, biological and epidemiological issues that are pertinent to conducting research on environmental exposures early in life and their health consequences over the life span.

scholarly journals Developmental Origins of Disease - Crisis Precipitates Change

2016 ◽  
Vol 39 (3) ◽  
pp. 919-938 ◽  
Author(s):  
Christoph Reichetzeder ◽  
Sulistyo Emantoko Dwi Putra ◽  
Jian Li ◽  
Berthold Hocher
Keyword(s):  
Later Life ◽  
Epidemiological Studies ◽  
Developmental Programming ◽  
Noncommunicable Disease ◽  
Developmental Origins ◽  
Comprehensive Overview ◽  
Developmental Origins Of Disease ◽  
Underlying Mechanisms ◽  
Early Life Events ◽  
The Impact

The concept of developmental origins of diseases has gained a huge interest in recent years and is a constantly emerging scientific field. First observations hereof originated from epidemiological studies, linking impaired birth outcomes to adult chronic, noncommunicable disease. By now there is a considerable amount of both epidemiological and experimental evidence highlighting the impact of early life events on later life disease susceptibility. Albeit far from being completely understood, more recent studies managed to elucidate underlying mechanisms, with epigenetics having become almost synonymous with developmental programming. The aim of this review was to give a comprehensive overview of various aspects and mechanisms of developmental origins of diseases. Starting from initial research foci mainly centered on a nutritionally impaired intrauterine environment, more recent findings such as postnatal nutrition, preterm birth, paternal programming and putative interventional approaches are summarized. The review outlines general underlying mechanisms and particularly discusses mechanistic explanations for sexual dimorphism in developmental programming. Furthermore, novel hypotheses are presented emphasizing a non-mendelian impact of parental genes on the offspring's phenotype.

scholarly journals Periconceptional environment and the developmental origins of disease

2019 ◽  
Vol 242 (1) ◽  
pp. T33-T49 ◽  
Author(s):  
Miguel A Velazquez ◽  
Tom P Fleming ◽  
Adam J Watkins
Keyword(s):  
Later Life ◽  
Developmental Origins ◽  
Critical Question ◽  
Physiological Mechanisms ◽  
Maternal Undernutrition ◽  
Increased Risk ◽  
Developmental Origins Of Disease ◽  
Developmental Programme ◽  
And Function ◽  
Maternal Overnutrition

The concept emerging from Professor David Barker’s seminal research on the developmental origins of later-life disease has progressed in many directions since it was first published. One critical question being when during gestation might environment alter the developmental programme with such enduring consequences. Here, we review the growing consensus from clinical and animal research that the period around conception, embracing gamete maturation and early embryogenesis might be the most vulnerable period. We focus on four types of environmental exposure shown to modify periconceptional reproduction and offspring development and health: maternal overnutrition and obesity; maternal undernutrition; paternal diet and health; and assisted reproductive technology. These conditions may act through diverse epigenetic, cellular and physiological mechanisms to alter gene expression and cellular signalling and function in the conceptus affecting offspring growth and metabolism leading to increased risk for cardiometabolic and neurological disease in later life.

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