Effect of methamphetamine exposure and cross-fostering on sensorimotor development of male and female rat pups

2009 ◽  
Vol 51 (1) ◽  
pp. 73-83 ◽  
Author(s):  
Lenka Hrubá ◽  
Barbora Schutová ◽  
Romana Šlamberová ◽  
Marie Pometlová ◽  
Richard Rokyta
Keyword(s):  
Female Rat ◽  
Male And Female ◽  
Sensorimotor Development ◽  
Rat Pups ◽  
Cross Fostering

scholarly journals In Utero and Lactational Exposure to TCDD; Steroidogenic Outcomes Differ in Male and Female Rat Pups

2005 ◽  
Vol 88 (2) ◽  
pp. 534-544 ◽  
Author(s):  
S. A. Myllymäki ◽  
T. E. Haavisto ◽  
L. J. S. Brokken ◽  
M. Viluksela ◽  
J. Toppari ◽  
...  
Keyword(s):  
In Utero ◽  
Female Rat ◽  
Male And Female ◽  
Lactational Exposure ◽  
Rat Pups

Effect of prenatal melatonin exposure on gonadotropins and prolactin secretion in male and female rat pups

2001 ◽  
Vol 424 (3) ◽  
pp. 229-235 ◽  
Author(s):  
Yuji Okatani ◽  
Akihiko Wakatsuki ◽  
Edet.E. Otukonyong ◽  
Yasuyo Miyahara
Keyword(s):  
Prolactin Secretion ◽  
Female Rat ◽  
Male And Female ◽  
Rat Pups

Persistence of metabolic consequences in the progeny of rats fed a HC formula in their early postnatal life

1995 ◽  
Vol 269 (4) ◽  
pp. E731-E738 ◽  
Author(s):  
S. Vadlamudi ◽  
S. C. Kalhan ◽  
M. S. Patel
Keyword(s):  
First Generation ◽  
Adult Life ◽  
Female Rats ◽  
Postnatal Life ◽  
Female Rat ◽  
Tissue Mass ◽  
Male And Female ◽  
Rat Pups ◽  
Male And Female Rats ◽  
Early Postnatal Life

First-generation (1-) male and female rat pups were either reared artificially on a high-carbohydrate (HC) or a high-fat (HF) formula or nursed by mother (MF) from day 4 and weaned onto a stock diet on day 24. 1-HC rats compared with sex-matched control rats (1-HF and 1-MF) were hyperinsulinemic and mildly obese by day 60. We investigated the effect of maternal hyperinsulinemia on the second generation (2-) by intragroup breeding. The 2-HC male and female rats were hyperinsulinemic on day 45, had significantly increased growth rate from approximately day 60 onward, and became obese as evidenced by increased adipose tissue mass due to hypertrophy on day 100. The lipogenic capacity of liver and adipose tissues was significantly higher in the 2-HC than in control rats. Thus the metabolic changes that occurred in the first-generation rats fed a HC formula during early postnatal life not only persisted into their adult life but were also passed on to the next generation.

scholarly journals Simulated Gastric Digestion and In Vivo Intestinal Uptake of Orally Administered CuO Nanoparticles and TiO2 E171 in Male and Female Rat Pups

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1487
Author(s):  
Ninell P. Mortensen ◽  
Maria Moreno Caffaro ◽  
Shyam Aravamudhan ◽  
Lakshmi Beeravalli ◽  
Sharmista Prattipati ◽  
...  
Keyword(s):  
Immune Cells ◽  
Early Life ◽  
Oral Exposure ◽  
Low Grade ◽  
Female Rat ◽  
Intestinal Uptake ◽  
Male And Female ◽  
Cuo Nps ◽  
Rat Pups

Oral exposure to nanoparticles (NPs) during early life is an understudied area. The goals of this study were to evaluate the effect of pre-weaned rat gastric fluids on 50 nm CuO NPs and TiO2 E171 in vitro, and to evaluate uptake in vivo. The NP uptake was studied in vivo in male and female Sprague-Dawley rat pups following oral administration of four consecutive daily doses of 10 mg/kg CuO NPs, TiO2 E171, or vehicle control (water) between postnatal day (PND) 7–10. Rat pups were sacrificed on either PND10 or PND21. Simulated digestion led to dissolution of CuO NPs at the later ages tested (PND14 and PND21, but not PND7). In vivo intestinal uptake of CuO NPs and TiO2 E171 was observed by hyperspectral imaging of intestinal cross sections. Brightfield microscopy showed that the number of immune cells increased in the intestinal tissue following NP administration. Orally administered NPs led to low intestinal uptake of NPs and an increase in immune cells in the small and large intestine, suggesting that oral exposure to NPs during early life may lead to irritation or a low-grade inflammation. The long-term impact of increased immune cells in the intestinal tract during early life is unknown.

SERUM CONCENTRATIONS OF TESTOSTERONE, OESTROGENS, LUTEINIZING HORMONE AND FOLLICLE-STIMULATING HORMONE IN MALE AND FEMALE RATS DURING THE CRITICAL PERIOD OF NEURAL SEXUAL DIFFERENTIATION

1979 ◽  
Vol 80 (1) ◽  
pp. 103-110 ◽  
Author(s):  
S. F. PANG ◽  
A. R. CAGGIULA ◽  
V. L. GAY ◽  
R. L. GOODMAN ◽  
C. S. F. PANG
Keyword(s):  
Post Partum ◽  
Serum Levels ◽  
Female Rats ◽  
Male Rats ◽  
Female Rat ◽  
Serum Concentrations ◽  
Male And Female ◽  
Rat Pups ◽  
Male And Female Rats ◽  
Sampling Times

Untreated male and female rat pups were killed 1–5 days post partum and the serum concentrations of testosterone, oestrogens, LH and FSH were determined by radioimmunoassay. At all five sampling times, the serum concentrations of testosterone in male rats were about three times higher than those in female rats, but serum levels of oestrogens did not differ between the sexes. Serum concentrations of LH and FSH were lower in male than in female pups. In another study, rats were decapitated 1–10 days after birth and serum concentrations of testosterone were determined with a different radioimmunoassay. Again, at all four sampling times, the concentration of testosterone was significantly higher in the male than in the female pups.

GONADOTROPHIN PATTERNS IN MALE AND FEMALE RATS:

1968 ◽  
Vol 58 (4) ◽  
pp. 600-612 ◽  
Author(s):  
Robert Boyd ◽  
Donald C. Johnson
Keyword(s):  
Ascorbic Acid ◽  
Testosterone Propionate ◽  
Female Rats ◽  
Female Rat ◽  
Feedback Effects ◽  
Male And Female ◽  
Prostate Weight ◽  
Male And Female Rats ◽  
Males And Females ◽  
Normal Males

ABSTRACT The effects of various doses of testosterone propionate (TP) upon the release of luteinizing hormone (LH or ICSH) from the hypophysis of a gonadectomized male or female rat were compared. Prostate weight in hypophysectomized male parabiotic partners was used to evaluate the quantity of circulating LH. Hypophyseal LH was measured by the ovarian ascorbic acid depletion method. Males castrated when 45 days old secreted significantly more LH and had three times the amount of pituitary LH as ovariectomized females. Administration of 25 μg TP daily reduced the amount of LH in the plasma, and increased the amount in the pituitary gland, in both sexes. Treatment with 50 μg caused a further reduction in plasma LH in males, but not in females, while pituitary levels in both were equal to that of their respective controls. LH fell to the same low level in partners of males or females receiving 100 μg TP. When gonadectomized at 39 days, males and females had the same amount of plasma LH, but males had more stored hormone. Pituitary levels were unchanged from controls following treatment with 12.5, 25 or 50 μg TP daily, but plasma values dropped an equal amount in both sexes with the latter two doses. Androgenized males or females, gonadectomized when 39 days old, were very sensitive to the effects of TP and plasma LH was significantly reduced with 12.5 μg daily. Pituitary LH in androgenized males was higher than that of normal males but was reduced to normal by small amounts of TP. The amount of stored LH in androgenized females was not different from that of normal females and it was unchanged by any dose of TP tested. Results are consistent with the conclusion that the male hypothalamic-hypophyseal axis is at least as sensitive as the female axis to the negative feedback effects of TP. Androgenization increases the sensitivity to TP in both males and females.

Sign in / Sign up

Export Citation Format

Share Document