scholarly journals Molecular signaling of G‐protein‐coupled receptor in chronic heart failure and associated complications

2019 ◽  
Vol 81 (1) ◽  
pp. 23-31
Author(s):  
Mohammad Altamish ◽  
Vijaya Paul Samuel ◽  
Rajiv Dahiya ◽  
Yogendra Singh ◽  
Pran Kishore Deb ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
G Protein ◽  
Molecular Signaling ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

Correlation Between Beta-Adrenoceptors and G-Protein-Coupled Receptor Kinases in Pretransplantation Heart Failure

2008 ◽  
Vol 40 (9) ◽  
pp. 3014-3016 ◽  
Author(s):  
J. Agüero ◽  
L. Almenar ◽  
P. D'Ocon ◽  
E. Oliver ◽  
F. Montó ◽  
...  
Keyword(s):  
Heart Failure ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Beta Adrenoceptors ◽  
Receptor Kinases ◽  
G Protein Coupled

scholarly journals Overview of Bile Acids Signaling and Perspective on the Signal of Ursodeoxycholic Acid, the Most Hydrophilic Bile Acid, in the Heart

Biomolecules ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 159 ◽  
Author(s):  
Noorul Izzati Hanafi ◽  
Anis Syamimi Mohamed ◽  
Siti Hamimah Sheikh Abdul Kadir ◽  
Mohd Hafiz Dzarfan Othman
Keyword(s):  
Heart Failure ◽  
Bile Acid ◽  
Chronic Heart Failure ◽  
Ursodeoxycholic Acid ◽  
Bile Acids ◽  
G Protein ◽  
Hormone Receptors ◽  
Nuclear Hormone Receptors ◽  
Heart Failure Patients ◽  
G Protein Coupled

Bile acids (BA) are classically known as an important agent in lipid absorption and cholesterol metabolism. Nowadays, their role in glucose regulation and energy homeostasis are widely reported. BAs are involved in various cellular signaling pathways, such as protein kinase cascades, cyclic AMP (cAMP) synthesis, and calcium mobilization. They are ligands for several nuclear hormone receptors, including farnesoid X-receptor (FXR). Recently, BAs have been shown to bind to muscarinic receptor and Takeda G-protein-coupled receptor 5 (TGR5), both G-protein-coupled receptor (GPCR), independent of the nuclear hormone receptors. Moreover, BA signals have also been elucidated in other nonclassical BA pathways, such as sphingosine-1-posphate and BK (large conductance calcium- and voltage activated potassium) channels. Hydrophobic BAs have been proven to affect heart rate and its contraction. Elevated BAs are associated with arrhythmias in adults and fetal heart, and altered ratios of primary and secondary bile acid are reported in chronic heart failure patients. Meanwhile, in patients with liver cirrhosis, cardiac dysfunction has been strongly linked to the increase in serum bile acid concentrations. In contrast, the most hydrophilic BA, known as ursodeoxycholic acid (UDCA), has been found to be beneficial in improving peripheral blood flow in chronic heart failure patients and in protecting the heart against reperfusion injury. This review provides an overview of BA signaling, with the main emphasis on past and present perspectives on UDCA signals in the heart.

scholarly journals G-protein-coupled receptor kinase activity in human heart failure: Effects of β-adrenoceptor blockade

2005 ◽  
Vol 66 (3) ◽  
pp. 512-519 ◽  
Author(s):  
K LEINEWEBER ◽  
P ROHE ◽  
A BEILFUS ◽  
C WOLF ◽  
H SPORKMANN ◽  
...  
Keyword(s):  
Heart Failure ◽  
G Protein ◽  
Human Heart ◽  
Kinase Activity ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Human Heart Failure ◽  
G Protein Coupled

scholarly journals Simultaneous Adrenal and Cardiac G-Protein–Coupled Receptor-Gβγ Inhibition Halts Heart Failure Progression

2014 ◽  
Vol 63 (23) ◽  
pp. 2549-2557 ◽  
Author(s):  
Fadia A. Kamal ◽  
Deanne M. Mickelsen ◽  
Katherine M. Wegman ◽  
Joshua G. Travers ◽  
Jacob Moalem ◽  
...  
Keyword(s):  
Heart Failure ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Heart Failure Progression ◽  
G Protein Coupled

scholarly journals G protein-coupled receptor kinase 2 as a therapeutic target for heart failure

2012 ◽  
Vol 9 (4) ◽  
pp. e155-e162 ◽  
Author(s):  
Sarah M. Schumacher-Bass ◽  
Christopher J. Traynham ◽  
Walter J. Koch
Keyword(s):  
Heart Failure ◽  
G Protein ◽  
Therapeutic Target ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Prognostic Value of Lymphocyte G Protein-Coupled Receptor Kinase-2 Protein Levels in Patients With Heart Failure

2016 ◽  
Vol 118 (7) ◽  
pp. 1116-1124 ◽  
Author(s):  
Giuseppe Rengo ◽  
Gennaro Pagano ◽  
Pasquale Perrone Filardi ◽  
Grazia Daniela Femminella ◽  
Valentina Parisi ◽  
...  
Keyword(s):  
Heart Failure ◽  
G Protein ◽  
Prognostic Value ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Protein Levels ◽  
Patients With Heart Failure ◽  
G Protein Coupled

scholarly journals Lymphocyte G-protein coupled receptor kinase 2 and cardiac mortality in heart failure

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P1486-P1486
Author(s):  
G. Rengo ◽  
G. Pagano ◽  
G. Galasso ◽  
G. D. Femminella ◽  
D. Liccardo ◽  
...  
Keyword(s):  
Heart Failure ◽  
G Protein ◽  
Cardiac Mortality ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled
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