Participation of ATP‐sensitive K+ channels and μ‐opioid receptors in the antinociceptive synergism of the paracetamol–tapentadol co‐administration in the formalin‐induced pain assay in mice

2018 ◽  
Vol 79 (8) ◽  
pp. 400-405 ◽  
Author(s):  
Juan R. Zapata‐Morales ◽  
Ángel J. Alonso‐Castro ◽  
Salud Pérez‐Gutiérrez ◽  
Edgar Isaac Rojas‐Bedolla ◽  
Sergio Sánchez‐Enriquez ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
K Channels ◽  
Μ Opioid Receptors

Extra-Synaptic Sites for Enkephalin Activation of μ-Opioid Receptors in the Rat Nucleus Accumbens

Analgesia ◽  
1995 ◽  
Vol 1 (4) ◽  
pp. 774-777
Author(s):  
Adena L. Svingos ◽  
Akiyoshi Moriwaki ◽  
Jia Bei Wang ◽  
George R. Uhl ◽  
Virginia M. Pickel
Keyword(s):  
Nucleus Accumbens ◽  
Opioid Receptors ◽  
Rat Nucleus Accumbens ◽  
Μ Opioid Receptors

Lifetime-Engineered Ruby Nanoparticles (Tau-Rubies) for Multiplexed Imaging of μ-Opioid Receptors

ACS Sensors ◽  
2021 ◽  
Vol 6 (3) ◽  
pp. 1375-1383
Author(s):  
Xiaohong Yang ◽  
Alireza Maleki ◽  
Nikolay A. Lipey ◽  
Xianlin Zheng ◽  
Marina Santiago ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Multiplexed Imaging ◽  
Μ Opioid Receptors

Dual motor responses elicited by ethanol in the posterior VTA: Consequences of the blockade of μ-opioid receptors

2015 ◽  
Vol 29 (9) ◽  
pp. 1029-1034 ◽  
Author(s):  
Lucía Martí-Prats ◽  
Alejandro Orrico ◽  
Ana Polache ◽  
Luis Granero
Keyword(s):  
Opioid Receptors ◽  
Motor Responses ◽  
Μ Opioid Receptors

Pretreatment of rats with the irreversible μ-receptor antagonist, β-FNA, fails to prevent naltrexone-induced upregulation of μ-opioid receptors

1990 ◽  
Vol 29 (9) ◽  
pp. 805-810 ◽  
Author(s):  
R.B. Rothman ◽  
J.B. Long ◽  
V. Bykov ◽  
A.E. Jacobson ◽  
K.C. Rice ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Opioid Receptors ◽  
Μ Opioid Receptors ◽  
Μ Receptor

Opioid Agonists Differentially Regulate μ-Opioid Receptors and Trafficking Proteins in Vivo

2002 ◽  
Vol 62 (6) ◽  
pp. 1464-1470 ◽  
Author(s):  
Minesh B. Patel ◽  
Chintan N. Patel ◽  
Vikram Rajashekara ◽  
Byron C. Yoburn
Keyword(s):  
Opioid Receptors ◽  
Opioid Agonists ◽  
Μ Opioid Receptors

Role of the NO-cGMP-K+ channels pathway in the peripheral antinociception induced by α-bisabolol

2021 ◽  
Author(s):  
Mario I Ortiz ◽  
Raquel Cariño-Cortés ◽  
Victor Manuel Muñoz Pérez ◽  
Andres Salas Casas ◽  
Gilberto Castañeda-Hernández
Keyword(s):  
Opioid Receptors ◽  
Formalin Test ◽  
Antinociceptive Effect ◽  
Dorsal Surface ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
K Channel ◽  
Formalin Injection ◽  
K Channels ◽  
The Right

The aim of this study was to examine if the peripheral antinociception of α-bisabolol involve the participation of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) synthesis followed by K+ channel opening in the formalin test. Wistar rats were injected in the dorsal surface of the right hind paw with formalin (1%). Rats received a subcutaneous injection into the dorsal surface of the paw of vehicles or increasing doses of α-bisabolol (100-300 µg/paw). To determine whether the peripheral antinociception induced by α-bisabolol was mediated by either the opioid receptors or the NO-cGMP-K+ channels pathway, the effect of pretreatment (10 min before formalin injection) with the appropriate vehicles, naloxone, naltrexone, L-NAME, ODQ, glibenclamide, glipizide, apamin, charybdotoxin, tetraethylammonium or 4-aminopyridine on the antinociceptive effects induced by local peripheral α-bisabolol (300 µg/paw) were assessed. α-bisabolol produced antinociception during both phases of the formalin test. α-bisabolol antinociception was blocked by L-NAME, ODQ, and all the K+ channels blockers. The peripheral antinociceptive effect produced by α-bisabolol was not blocked by the opioid receptor inhibitors. α-bisabolol was able to active the NO-cGMP-K+ channels pathway in order to produce its antinoceptive effect. The participation of opioid receptors in the peripheral local antinociception induced by α-bisabolol is excluded.

18F-Labeled sufentanil for PET-imaging of μ-opioid receptors

2005 ◽  
Vol 15 (7) ◽  
pp. 1773-1777 ◽  
Author(s):  
Gjermund Henriksen ◽  
Stefan Platzer ◽  
Andrea Hauser ◽  
Frode Willoch ◽  
Achim Berthele ◽  
...  
Keyword(s):  
Opioid Receptors ◽  
Pet Imaging ◽  
Μ Opioid Receptors

scholarly journals Usefulness for the combination of G protein- and β-arrestin-biased ligands of μ-opioid receptors: Prevention of antinociceptive tolerance

2017 ◽  
Vol 13 ◽  
pp. 174480691774003 ◽  
Author(s):  
Tomohisa Mori ◽  
Naoko Kuzumaki ◽  
Takamichi Arima ◽  
Michiko Narita ◽  
Ryunosuke Tateishi ◽  
...  
Keyword(s):  
G Protein ◽  
Opioid Receptors ◽  
Antinociceptive Tolerance ◽  
Μ Opioid Receptors
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