Computational and experimental exploration of the structure-activity relationships of flavonoids as potent glyoxalase-I inhibitors

2017 ◽  
Vol 79 (2) ◽  
pp. 58-69 ◽  
Author(s):  
Qosay A. Al-Balas ◽  
Mohammad A. Hassan ◽  
Nizar A. Al-Shar'i ◽  
Tamam El-Elimat ◽  
Ammar M. Almaaytah
Keyword(s):  
Glyoxalase I ◽  
Structure Activity Relationships ◽  
Structure Activity

Bacterial glyoxalase I enzymes: structural and biochemical investigations

2014 ◽  
Vol 42 (2) ◽  
pp. 479-484 ◽  
Author(s):  
John F. Honek
Keyword(s):  
Metal Ion ◽  
Molecular Structures ◽  
Glyoxalase I ◽  
Structure Activity Relationships ◽  
Structure Activity

A number of bacterial glyoxalase I enzymes are maximally activated by Ni2+ and Co2+ ions, but are inactive in the presence of Zn2+, yet these enzymes will also bind this metal ion. The structure–activity relationships between these two classes of glyoxalase I serve as important clues as to how the molecular structures of these proteins control metal-activation profiles.

Structure-activity relationships in the acronycine and benzo[b]acronycine series: Role of the pyran ring

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
Q Do ◽  
H Doan Thi Mai ◽  
T Gaslonde ◽  
B Pfeiffer ◽  
S Léonce ◽  
...  
Keyword(s):  
Pyran Ring ◽  
Structure Activity Relationships ◽  
Structure Activity

Structure activity-relationships of P-Glycoprotein modulation using a small library of macrocyclic lathyrane diterpenes

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
M Reis ◽  
RJ Ferreira ◽  
MMM Santos ◽  
DJVA dos Santos ◽  
J Molnár ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity ◽  
P Glycoprotein
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