Optical Spectroscopy and Multivariate Analysis for Biodosimetry and Monitoring of Radiation Injury to the Skin

2012 ◽  
Vol 73 (5) ◽  
pp. 252-273 ◽  
Author(s):  
Tatiana G. Levitskaia ◽  
Samuel A. Bryan ◽  
Jeffrey A. Creim ◽  
Terry L. Curry ◽  
Teresa Luders ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Optical Spectroscopy ◽  
Radiation Injury

Intraspecific differentiation of sandflies specimens by optical spectroscopy and multivariate analysis

2021 ◽  
Author(s):  
Aline E. Casaril ◽  
Carlos G. Santos ◽  
Bruno S. Marangoni ◽  
Sandro M. Lima ◽  
Luis H.C. Andrade ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Optical Spectroscopy ◽  
Intraspecific Differentiation

In Vivo Optical Spectroscopy Detects Radiation Damage in Brain Tissue

Neurosurgery ◽  
2005 ◽  
Vol 57 (3) ◽  
pp. 518-525 ◽  
Author(s):  
Wei-Chiang Lin ◽  
Anita Mahadevan-Jansen ◽  
Mahlon D. Johnson ◽  
Robert J. Weil ◽  
Steven A. Toms
Keyword(s):  
Radiation Damage ◽  
Optical Spectroscopy ◽  
Diffuse Reflectance ◽  
Radiation Injury ◽  
Hippocampal Sclerosis ◽  
Spectral Feature ◽  
Recurrent Tumor ◽  
Previous Irradiation ◽  
Brain Tissues

ABSTRACT OBJECTIVE: Magnetic resonance imaging abnormalities in malignant brain tumors after irradiation may represent either recurrent tumor or radiation injury. Optical spectroscopy may represent a novel technique to identify radiation damage in brain tissues and to differentiate contrast-enhancing lesions from recurrent tumor. METHODS: Fluorescence and diffuse reflectance spectra were acquired from 90 patients: 15 undergoing surgical resection for presumed recurrent tumor after radiation therapy, 15 with epilepsy and hippocampal sclerosis, and 60 with tumors who had not received irradiation. Optical spectra were acquired from 6 to 10 sites and were compared with a biopsy obtained from beneath the optical spectroscopy probe; the data then were classified by a neuropathologist blinded to the spectroscopy data. A probe for the intraoperative collection of diffuse reflectance and fluorescence spectra was used. RESULTS: Thirteen of 15 patients (29 of 129 spectra) with previous irradiation showed a unique spectral feature characterized by a fluorescence peak centered at 500 nm (F500). All biopsy specimens showing histopathological signs of radiation injury had the F500 on their corresponding spectra (18 of 18). The F500 was identified in another 10% (11 of 111 spectra) of samples with previous irradiation but no histologically identifiable signs of radiation damage. The F500 was never seen in the normal temporal lobe of epilepsy patients with hippocampal sclerosis (0 of 105) and was seen in only 1.5% of tumor patients who did not undergo previous irradiation (6 of 433). CONCLUSION: Optical spectroscopy detects radiation damage in brain tissues. The F500 spectral peak may allow accurate selection of tissues for biopsy in evaluating patients with new, contrast-enhancing lesions in the setting of previous irradiation.

Statistical analysis of classification

1966 ◽  
Vol 24 ◽  
pp. 188-189
Author(s):  
T. J. Deeming
Keyword(s):  
Multivariate Analysis ◽  
Statistical Analysis ◽  
Classification Scheme ◽  
Analytical Procedure ◽  
Narrow Band ◽  
Scientific Research ◽  
Maximum Amount ◽  
Amount Of Information

If we make a set of measurements, such as narrow-band or multicolour photo-electric measurements, which are designed to improve a scheme of classification, and in particular if they are designed to extend the number of dimensions of classification, i.e. the number of classification parameters, then some important problems of analytical procedure arise. First, it is important not to reproduce the errors of the classification scheme which we are trying to improve. Second, when trying to extend the number of dimensions of classification we have little or nothing with which to test the validity of the new parameters.Problems similar to these have occurred in other areas of scientific research (notably psychology and education) and the branch of Statistics called Multivariate Analysis has been developed to deal with them. The techniques of this subject are largely unknown to astronomers, but, if carefully applied, they should at the very least ensure that the astronomer gets the maximum amount of information out of his data and does not waste his time looking for information which is not there. More optimistically, these techniques are potentially capable of indicating the number of classification parameters necessary and giving specific formulas for computing them, as well as pinpointing those particular measurements which are most crucial for determining the classification parameters.

EP2 receptor null mice have an impaired intestinal response to radiation injury

2001 ◽  
Vol 120 (5) ◽  
pp. A10-A10
Author(s):  
C HOUCHEN ◽  
B DIECKGRAEFE ◽  
M STUMOSKI ◽  
W STENSON
Keyword(s):  
Radiation Injury ◽  
Ep2 Receptor

1118: The Incidence and Duration of Postoperative Ileus in Patients Undergoing Radical Cystectomy. A Multivariate Analysis of Contributing Factors

2005 ◽  
Vol 173 (4S) ◽  
pp. 303-303
Author(s):  
Diana Wiessner ◽  
Rainer J. Litz ◽  
Axel R. Heller ◽  
Mitko Georgiev ◽  
Oliver W. Hakenberg ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Radical Cystectomy ◽  
Postoperative Ileus ◽  
Contributing Factors
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