Inhibitory effects of novel tetrahydropyridine derivatives on nitric oxide and reactive oxygen species production in glioma cells

2004 ◽  
Vol 61 (4) ◽  
pp. 189-196
Author(s):  
Kyoung Jin P. Yoon ◽  
Kinfe K. Redda ◽  
Elizabeth Mazzio ◽  
Karam F.A. Soliman
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen Species Production ◽  
Glioma Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Inhibitory Effects ◽  
Species Production

Danshensu Attenuates Hypoxia-Induced Reactive Oxygen Species Production and Inducible Nitric Oxide Synthase Expression in RAW 264.7 Cells

2019 ◽  
Vol 18 (1) ◽  
pp. 89-95
Author(s):  
Lin Chih-Hung ◽  
Lan Chou-Chin ◽  
Chiu Valeria ◽  
Hsieh Po-Chun ◽  
Kuo Chan-Yen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Oxygen Species ◽  
Species Production ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Danshensu, isolated from Salvia miltiorrhiza (Danshen), is known to have anti-inflammatory properties. Therefore danshen is extensively used in many nutraceutical formulations. Reactive oxygen species are essential for the development of hypoxia-induced inflammation. Generation of reactive oxygen species by infiltrating macrophages is common in various diseases such as cardiovascular disease, neurodegenerative disease, tumor, and aging. To explore the mechanism underlying the attenuation of inflammation, we used RAW 264.7 cells as a model and hypoxia as an inducer of inflammation. The results showed the protective mechanism of danshensu on reactive oxygen species production, hypoxia-inducible factor 1-alpha expression, c-Jun N-terminal kinase phosphorylation, nuclear translocation of nuclear factor kappa B, and inducible nitric oxide synthase expression following hypoxia in RAW 264.7 cells.

β-Adrenergic receptor function and oxygen radical production in bovine pulmonary alveolar macrophages

1988 ◽  
Vol 66 (12) ◽  
pp. 1538-1541 ◽  
Author(s):  
P. D. Conlon ◽  
P. O. Ogunbiyi ◽  
W. D. Black ◽  
P. Eyre
Keyword(s):  
Reactive Oxygen Species ◽  
Alveolar Macrophages ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Inhibitory Effects ◽  
Ici 118,551 ◽  
Oxygen Radical Production ◽  
Pulmonary Alveolar Macrophages ◽  
Species Production

Reactive oxygen species production by bovine pulmonary alveolar macrophages was evaluated by a chemiluminescence assay utilizing luminol and opsonized zymosan. Incubation with dobutamine (5 × 10−8 and 5 × 10−7 M) or isoproterenol (5 × 10−8 and 5 × 10−7 M) prior to zymosan challenge significantly (p < 0.05) increased the time for chemiluminescence to begin, and significantly decreased the level of maximum chemiluminescence. The agonists' inhibitory effects on maximum chemiluminescence were significantly reduced by pre-incubation with the appropriate antagonist (atenolol at 1 × 10−6 M for dobutamine; and propranolol at 1 × 10−6 M for isoproterenol). Salbutamol at 1 × 10−6 M significantly reduced the level of maximum chemiluminescence only, but did not increase the time for chemiluminescence to begin. This effect was significantly reduced by the presence of the β2-antagonist ICI 118,551 at 1 × 10−6 M. The results reveal the presence of (β1- and (β2-adrenoceptors on bovine pulmonary alveolar macrophages, and suggest that these receptors are important in the regulation of reactive oxygen species production by these cells.

Effects of Nitric Oxide on Reactive Oxygen Species Production and Infarction Size after Brain Reperfusion Injury

Neurosurgery ◽  
2001 ◽  
Vol 48 (4) ◽  
pp. 884-893 ◽  
Author(s):  
Ryszard M. Pluta ◽  
Ramin Rak ◽  
David A. Wink ◽  
John J. Woodward ◽  
Ahmed Khaldi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Reperfusion Injury ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Infarction Size ◽  
Brain Reperfusion ◽  
Species Production

scholarly journals Nitric Oxide and Reactive Oxygen Species Production Causes Progressive Damage in Rats after Cessation of Silica Inhalation

2005 ◽  
Vol 90 (1) ◽  
pp. 188-197 ◽  
Author(s):  
Dale W. Porter ◽  
Lyndell L. Millecchia ◽  
Patsy Willard ◽  
Victor A. Robinson ◽  
Dawn Ramsey ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Progressive Damage ◽  
Oxygen Species ◽  
Species Production
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