In vivo studies of the release of adenine 5?-nucleotides, adenosine, and its metabolites from the rat brain

2003 ◽  
Vol 58 (4) ◽  
pp. 412-419 ◽  
Author(s):  
John W. Phillis ◽  
Michael H. O'Regan
Keyword(s):  
Rat Brain ◽  
In Vivo Studies

In vivo studies on the conversion of m-tyrosine to 3,4-dihydroxyphenylalanine in the rat

1977 ◽  
Vol 55 (10) ◽  
pp. 1103-1107 ◽  
Author(s):  
J. H. Tong ◽  
R. G. Smyth ◽  
N. L. Benoiton ◽  
A. D'Iorio
Keyword(s):  
Rat Brain ◽  
Enzyme Inhibitors ◽  
Phenylalanine Hydroxylase ◽  
Intraperitoneal Administration ◽  
In Vivo Studies ◽  
Dopa Decarboxylase ◽  
Decarboxylase Inhibitor ◽  
Specific Enzyme ◽  
Dihydroxyphenylacetic Acid

The question whether m-tyrosine can give rise to catechols in vivo has been investigated using labelled precursor. DL-[2-l4C]m-tyrosine (38 μCi/mmol (1 Ci = 37 GBq)) was synthesized from [2-14C]glycine. Radioactive catechols in rat brain, liver, and kidneys were examined 15 min after intraperitoneal administration of DL-[2-14C]m-tyrosine (100 mg/kg). The kidney was the only organ which showed demonstrable amounts of radioactive catechols, and about 14% of the catechols formed was identified as 3,4-dihydroxyphenylalanine (dopa), 22% as 3,4-dihydroxyphenylacetic acid, and 56% as dopamine. However, when the animals were pretreated with dopa decarboxylase inhibitor, labelled catechols were also observed in liver and brain, and dopa accounted for over 95% of the catechols formed in all three organs examined. Thus it is clear that m-tyrosine can be hydroxylated in vivo. Results from experiments using [2-14C]m-tyrosine enantiomers and specific enzyme inhibitors suggest that phenylalanine hydroxylase could be the enzyme catalyzing this reaction.

Interaction of β-casomorphins with multiple opioid receptors: In vitro and in vivo studies in the newborn rat brain

1986 ◽  
Vol 30 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Andrea Volterra ◽  
Patrizia Restani ◽  
Nicoletta Brunello ◽  
Corrado L. Galli ◽  
Giorgio Racagni
Keyword(s):  
Rat Brain ◽  
Opioid Receptors ◽  
In Vivo Studies ◽  
Newborn Rat

High affinity dopamine D2 receptor radioligands. 3. [123I] and [125I]epidepride: In vivo studies in rhesus monkey brain and comparison with in vitro pharmacokinetics in rat brain

Life Sciences ◽  
1993 ◽  
Vol 53 (3) ◽  
pp. 241-250 ◽  
Author(s):  
Robert M. Kessler ◽  
John R. Votaw ◽  
Dennis E. Schmidt ◽  
M. Sib Ansari ◽  
Karen P. Holdeman ◽  
...  
Keyword(s):  
Rhesus Monkey ◽  
Rat Brain ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
In Vivo Studies ◽  
Monkey Brain ◽  
High Affinity ◽  
Rhesus Monkey Brain
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