Cytostructural localization of peanut lectin binding in fine-needle aspirates of benign and malignant breast lesions

1987 ◽  
Vol 3 (4) ◽  
pp. 311-313
Author(s):  
Michelle J. Henry ◽  
Charles A. Horwitz ◽  
Michael W. Stanley
Keyword(s):  
Lectin Binding ◽  
Breast Lesions ◽  
Peanut Lectin ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Malignant Breast

scholarly journals Telomerase Activity in Benign and Malignant Breast Lesions: a Pilot Prospective Study on Fine-Needle Aspirates

1998 ◽  
Vol 90 (7) ◽  
pp. 537-539 ◽  
Author(s):  
Raffaella Villa ◽  
Nadia Zaffaroni ◽  
Marco Folini ◽  
Maria Grazia Daidone ◽  
Rosella Silvestrini ◽  
...  
Keyword(s):  
Prospective Study ◽  
Telomerase Activity ◽  
Breast Lesions ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Malignant Breast

Telomerase Is a Highly Sensitive and Specific Molecular Marker in Fine-Needle Aspirates of Breast Lesions

1999 ◽  
Vol 17 (7) ◽  
pp. 2020-2020 ◽  
Author(s):  
Christopher Poremba ◽  
Kenneth R. Shroyer ◽  
Michael Frost ◽  
Raihanatou Diallo ◽  
Franz Fogt ◽  
...  
Keyword(s):  
Malignant Tumors ◽  
Final Diagnosis ◽  
Specific Marker ◽  
Breast Lesions ◽  
Cytologic Diagnosis ◽  
Histologic Diagnosis ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Highly Sensitive ◽  
Immortal Cells

PURPOSE: Telomerase has been detected in a majority of human malignant tumors, making telomerase activity (TA) one key difference between mortal and immortal cells. In this study, we evaluated in blind-trial fashion the association of TA with cytologic and final clinical/pathologic diagnosis in fine-needle aspirates (FNAs) of breast lesions. MATERIALS AND METHODS: In 172 FNAs, including 80 samples that were cytologically malignant, 18 that were atypical but not diagnostic for malignancy, and 74 that were cytologically benign, TA was determined by a modified nonradioactive telomeric repeat amplification protocol (TRAP) assay. Final diagnosis was made by pathologic examination of follow-up surgical material available for all the cytologically malignant samples, a majority of the cytologically atypical samples, and a portion of the cytologically benign samples. RESULTS: TA was detected in 85 of 172 samples. Comparison of the cytologic and histologic diagnoseswith TA showed that 80 of 87 samples from patients with breast cancer were telomerase-positive, resulting in a sensitivity of 92%. TA was found in four of five FNAs from carcinomas that were considered cytologically atypical but not diagnostic for malignancy. Eighty of 85 samples from patients with benign breast lesions were telomerase-negative, revealing a specificity of 94%. The five positive cases in this group were all fibroadenomas with low TA. Among the 18 cases with a cytologic diagnosis of atypia, there was a strong positive relationship between TRAP findings and histologic diagnosis. CONCLUSION: The detection of TA in FNAs of breast lesions is a highly sensitive and specific marker of malignancy and may be used as an adjunct in cases with an equivocal cytologic diagnosis.

scholarly journals Distribution of breast lesions diagnosed by cytology examination in symptomatic patients at Eritrean National Health Laboratory, Asmara, Eritrea: a retrospective study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Kidane Siele Embaye ◽  
Saud Mohammed Raja ◽  
Medhanie Haile Gebreyesus ◽  
Matiwos Araya Ghebrehiwet
Keyword(s):  
National Health ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Malignant Breast ◽  
Needle Aspiration Cytology ◽  
Age Range

Abstract Background Fine needle aspiration cytology is a simple, relatively accurate, non-invasive, and cost-effective method of diagnosing most breast pathologies. To date, there is no sufficient data depicting the distribution of breast lesions detected by fine needle aspiration cytology in our healthcare setting. The aim of this study was to elucidate the general distribution of breast lesions diagnosed by cytology test at Eritrean National Health Laboratory. Methods This retrospective study was carried out on 905 symptomatic patients between the years 2013 and 2017 at Eritrean National Health Laboratory. Diagnosis was made by fine needle aspiration cytology in patients with palpable breast lump and in some patients direct smear was prepared from a nipple discharge. Statistical analysis was carried out using Statistical Package for the Social Sciences version 23. Results A total of 905 patients were included in the study, of whom 871 (96.24%) were females. The age range of patients was from 13 to 93 years with mean and standard deviation of 33 ± 14.9 years. Breast lump, occurring in 892 (98.56%), was the most frequent presenting symptom. Fibroadenoma and fibrocystic breast lesions were the most prevalent lesions accounting for approximately 40% and 15%, respectively. Malignant breast lesions were seen predominantly in females above the age of 40 years with the highest frequency observed in the age range between 51 and 60 years. Pearson Chi-squared test showed significant association between patients’ age above 40 years and the risk of having a malignant breast lesion (p < 0.001). The highest number of benign and malignant breast lesions was documented in 2014 with little fluctuation elsewhere in the study period. Conclusion Fine needle aspiration cytology is a procedure of choice for preoperative diagnosis in breast lesions mainly in a resource-limited settings. Our study identified the occurrence of malignant breast lesions in young women, which is of a paramount public health concern. Of note, significant proportion of patients were late to seek medical attention. Therefore, enhancement of community awareness regarding breast disease and implementation of screening programs are necessary to ameliorate the morbidity and mortality associated with the disease.

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