Solitary cutaneous metastasis from an ovarian high‐grade serous carcinoma at the initial presentation: Cytologic diagnosis of a rare manifestation

2021 ◽  
Author(s):  
Amarjot Kaur ◽  
Parikshaa Gupta ◽  
Nalini Gupta ◽  
Bhavana Rai
Keyword(s):  
Cutaneous Metastasis ◽  
Initial Presentation ◽  
Serous Carcinoma ◽  
High Grade ◽  
Cytologic Diagnosis ◽  
Rare Manifestation

scholarly journals Solitary CNS Metastasis on Initial Presentation of High Grade Serous Carcinoma of the Fallopian Tube

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Felicity Harl ◽  
Cassandra Niemi ◽  
Lori Mankowski Gettle ◽  
Paul Weisman ◽  
Stephen Rose
Keyword(s):  
Fallopian Tube ◽  
Brain Lesion ◽  
Primary Site ◽  
Initial Presentation ◽  
Serous Carcinoma ◽  
High Grade ◽  
Metastatic Adenocarcinoma ◽  
Cns Metastasis ◽  
Small Primary ◽  
History Of

A 68-year-old woman presented with a three-week history of confusion and anomic aphasia. Imaging of her head demonstrated a single large left frontal mass. Pathology revealed metastatic adenocarcinoma of Müllerian origin. Subsequent surgery revealed a small primary site in a fallopian tube, high left para-aortic lymphadenopathy, and no disseminated intraperitoneal disease. This case was remarkable in that CNS metastasis was her presenting symptom and was restricted to a solitary brain lesion, and other disease sites were limited to retroperitoneal lymphadenopathy and a small fallopian tube primary.

scholarly journals Cytologic diagnosis of undifferentiated high grade pleomorphic sarcoma of breast presenting with brain metastasis

2013 ◽  
Vol 04 (02) ◽  
pp. 188-190
Author(s):  
Indranil Chakrabarti ◽  
Nilanjana Ghosh ◽  
Amita Giri
Keyword(s):  
Brain Metastasis ◽  
Initial Presentation ◽  
High Grade ◽  
Cytologic Diagnosis ◽  
Aspiration Cytology ◽  
Primary Sarcoma ◽  
Pleomorphic Sarcoma ◽  
The Brain ◽  
Rare Diagnosis ◽  
Cerebellar Metastasis

ABSTRACTPrimary sarcoma of breast are rare. Diagnosis by aspiration cytology is difficult due to nonspecific cytomorphologic features. An initial presentation with neurological symptoms due to metastasis of breast sarcoma to the brain has not been previously reported. Here, we describe a case of a 60‑year-old female who presented with headache, dizziness and convulsion and was subsequently diagnosed with undifferentiated high grade pleomorphic sarcoma of breast with cerebellar metastasis.

scholarly journals Targeting progesterone signaling prevents metastatic ovarian cancer

2020 ◽  
Vol 117 (50) ◽  
pp. 31993-32004
Author(s):  
Olga Kim ◽  
Eun Young Park ◽  
Sun Young Kwon ◽  
Sojin Shin ◽  
Robert E. Emerson ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Deleterious Mutation ◽  
Peritoneal Metastases ◽  
Cancer Development ◽  
Serous Carcinoma ◽  
Cancer Type ◽  
High Grade ◽  
Primary Tumors ◽  
High Risk Populations ◽  
Genetic Deletion

Effective cancer prevention requires the discovery and intervention of a factor critical to cancer development. Here we show that ovarian progesterone is a crucial endogenous factor inducing the development of primary tumors progressing to metastatic ovarian cancer in a mouse model of high-grade serous carcinoma (HGSC), the most common and deadliest ovarian cancer type. Blocking progesterone signaling by the pharmacologic inhibitor mifepristone or by genetic deletion of the progesterone receptor (PR) effectively suppressed HGSC development and its peritoneal metastases. Strikingly, mifepristone treatment profoundly improved mouse survival (∼18 human years). Hence, targeting progesterone/PR signaling could offer an effective chemopreventive strategy, particularly in high-risk populations of women carrying a deleterious mutation in the BRCA gene.

Clinical Outcomes of Patients with High-Grade Ovarian Carcinoma Arising in Endometriosis Compared to Ovarian High-Grade Serous Carcinoma

2021 ◽  
Vol 19 (4) ◽  
Author(s):  
Ibrahim Yalcin ◽  
Hanifi Sahin ◽  
Mustafa Erkan Sari ◽  
Asuman Nihan Haberal ◽  
Eda Adeviye Sahin ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Clinical Outcomes ◽  
Serous Carcinoma ◽  
High Grade
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