Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia in conjunction with parotid basal cell adenoma: Cytologic, histologic, and molecular features

2021 ◽  
Author(s):  
Mushal Noor ◽  
Donna K. Russell ◽  
Anna‐Karoline Israel ◽  
Abberly Lott Limbach
Keyword(s):  
Basal Cell ◽  
Mucoepidermoid Carcinoma ◽  
Basal Cell Adenoma ◽  
Cell Adenoma ◽  
Molecular Features ◽  
Sclerosing Mucoepidermoid Carcinoma

scholarly journals An Unusual Hybrid Salivary Gland Tumor: Molecular Analysis Informs the Potential Pathogenesis of This Rare Neoplasm

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Yan Zhou ◽  
Ernesto Martinez Duarte ◽  
David J. Eleff ◽  
Laura J. Tafe ◽  
Jason M. Leibowitz ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Molecular Analysis ◽  
Basal Cell ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Tumor ◽  
Clinical History ◽  
Genetic Alterations ◽  
Basal Cell Adenoma ◽  
Gland Tumor ◽  
Cell Adenoma

Background. The presence of two or more tumor entities growing in adjacent locations within the salivary gland is very rare, and pathologic studies on such lesions are limited, particularly those with molecular information. Since the clinical history and imaging studies are usually nonspecific, accurate diagnosis and clinical management largely depend on a thorough histological examination. Methods and Results. We describe a 71-year-old man with an unusual case of hybrid salivary gland tumor composed of mucoepidermoid carcinoma and basal cell adenoma. Molecular analysis revealed differing driver genetic alterations in each component. Conclusions. Hybrid salivary gland tumors are rare, and their pathogenesis is controversial. The combination of mucoepidermoid carcinoma and basal cell adenoma has not been previously described. While malignant transformation of adenoma to carcinoma seems plausible, gene sequencing was more suggestive of their independent derivation. Key to appropriate surgical management is identifying the more aggressive component, ideally at the time of intraoperative consultation.

scholarly journals PROFIL PENDERITA TUMOR KELENJAR LIUR DI RSUP PROF. DR. R.D. KANDOU MANADO PERIODE JULI 2012-JUNI 2015

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Wirawan Iman ◽  
Marselus Merung ◽  
Ainun Aschorijanto
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Basal Cell ◽  
Mucoepidermoid Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Basal Cell Adenoma ◽  
Cell Adenoma

Abstract: Salivary glands tumours are relatively rare to find. There is still no adequate data about the incidence of salivary gland tumours in Indonesia. The main objective of this research was to cognise the profile of salivary glands tumours patients in Prof. Dr. R.D. Kandou Central General Hospital Manado from July 2012 to June 2015. Methods used is descriptive retrospective. The results showed there are 37 patients with salivary gland(s) tumour(s). Male was 59,5% and female was 40,5%. By age groups found that <19 years for 2.7%, 19-30 years for 8,2%, 31-45 years for 21.6%, 46-60 years for 37,8%, >60 years for 29,7%. Based on the histopathological classification, pleomorphic adenoma for 56.8%, Whartin's tumor for 8.1%, myoepithelioma for 2,7%, basal cell adenoma for 2.7%, oncocytoma for 2.7%, cystadenoma for 5.4%, canalicular adenoma for 2.7%, mucoepidermoid carcinoma for 10.8%, adenocarcinoma for 5.4%, and acinic cell carcinoma for 2.7%. Based on the location of the tumours’ appearance, parotid gland for 83.8%, submandibular gland for 13.5%, minor salivary glands for 2.7%. Based by the incidences annually, first year for 21.6%, second year for 32.3%, and the third year for 46.1%.Conclusion: Males are more than females, most commonly found in the age group of 51-60 years, the most commonly benign tumour found is the pleomorphic adenoma, the most commonly found malign tumour is mucoepidermoid carcinoma, the most commonly location of the tumours’ appearance is the parotid gland. The salivary glands tumours continued to increase during the last three years.Suggestion: Still necessary to do further research about salivary glands tumours.Keywords: salivary glands tumours, age, gender, histopathology, location, profileAbstrak : Tumor kelenjar liur adalah tumor yang relatif sedikit dijumpai ditemukan. Belum ditemukan data yang lengkap tentang kejadian tumor kelenjar liur di Indonesia. Tujuan utama dari penelitian ini adalah untuk mengetahui profil penderita tumor kelenjar liur di RSUP Prof. Dr. R.D. Kandou Manado periode Juli 2012-Juni 2015. Metode penelitian yang digunakan adalah deskriptif retrospektif. Hasil penelitian memperlihatkan terdapat 37 penderita tumor kelenjar liur. Laki-laki sebanyak 59,5% dan perempuan 40,5%. Kelompok usia <16 tahun sebanyak 2,7%, 16-30 tahun sebanyak 8,1%, 31-45 tahun sebanyak 21,6%, 46-60 tahun sebanyak 37,8%, >60 tahun sebanyak 29,7%. Berdasarkan klasifikasi histopatologi jenis pleomorphic adenoma sebanyak 56,8%, Whartin’s tumor sebanyak 8,2%, myoepithelioma sebanyak 2,7%, basal cell adenoma sebanyak 2,7%, oncocytoma sebanyak 2,7%, cystadenoma sebanyak 5,4%, canalicular adenoma sebanyak 2,7%, mucoepidermoid carcinoma sebanyak 10,8%, adenocarcinoma sebanyak 5,4%, acinic cell carcinoma sebanyak 2,7%. Berdasarkan lokasi munculnya tumor, kelenjar parotis sebanyak 83,8%, kelenjar submandibula sebanyak 13,5%, kelenjar liur minor sebanyak 2,7%. Berdasarkan jumlah pertahunnya, tahun pertama sebanyak 21,6%, tahun kedua sebanyak 32,3%, dan tahun ketiga sebanyak 46,1%.Kesimpulan : Penderita laki-laki lebih banyak daripada perempuan, paling banyak ditemukan pada kelompok usia 46-60 tahun, tumor jinak yang paling banyak ditemukan adalah pleomorphic adenoma, tumor ganas yang paling banyak ditemukan adalah mucoepidermoid carcinoma, lokasi tersering munculnya tumor adalah kelenjar parotis. Penderita tumor kelenjar liur terus meningkat selama tiga tahun terakhir.Saran : Perlu dilakukan penelitian lebih lanjut tentang tumor kelenjar liurKata Kunci : tumor kelenjar liur, usia, jenis kelamin, histopatologi, lokasi, profil

scholarly journals Parotid gland tumors: clinical experience at tertiary care center

2018 ◽  
Vol 5 (1) ◽  
pp. 14
Author(s):  
Pritosh Sharma ◽  
Abhijit Vasantkumar Makwana ◽  
Rini Bishnoi ◽  
Shifa Vyas ◽  
Vinod Prakash Goyal
Keyword(s):  
Parotid Gland ◽  
Diagnostic Accuracy ◽  
Pleomorphic Adenoma ◽  
Basal Cell ◽  
Predictive Value ◽  
Mucoepidermoid Carcinoma ◽  
Cystic Lesion ◽  
Basal Cell Adenoma ◽  
Cell Adenoma ◽  
Pathology Department

<p class="abstract"><strong>Background:</strong> The objective of this study is to evaluate the diagnostic accuracy of FNAC in parotid gland lesions and it’s correlation with HPE, for better management of patient.</p><p class="abstract"><strong>Methods:</strong> A total of 46 FNAC were done of parotid gland lesion in Pathology department of GMCH from 2016 to 2018. Out of 46 patients of parotid gland lesions 44 were surgically resected by ENT Dept GMCH and formalin fixed specimen were sent to Pathology department and slides were prepared. The cytology and HPE stained slides were studied and correlated clinically.  </p><p class="abstract"><strong>Results:</strong> The cytology features of 44 cases are correlated with HPE. In cytology study: pleomorphic adenoma in 31, benign cystic lesion in 07, basal cell adenoma in 01, mucoepidermoid carcinoma in 04 and adenocystic carcinoma in 01. In HPE study: pleomorphic adenoma in 28, benign cystic lesion in 04, basal cell adenoma in 02 and warthin’s tumor in 02, adenocystic carcinoma in 02, mucoepidermoid carcinoma in 03, acinic cell carcinoma in 01, carcinoma of EX pleomorphic adenoma in 01 and cystadeno carcinoma in 02. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy are respectively 55.55%, 100%, 100%, 89.74% and 90.90%.</p><p class="abstract"><strong>Conclusions:</strong> FNAC of the parotid gland is safe and reliable technique in the primary diagnosis of salivary gland lesion. Although, sensitivity of this test has some limitation and to differentiate specific malignant lesion. This study has shown that FNAC has low sensitivity, high specificity, diagnostic accuracy, simple and cost effective for the patients of parotid gland lesion.</p>

scholarly journals Management of Basal Cell Adenoma of Accessory Parotid Gland Through Transoral Approach: Report of a Rare Case With Review

2021 ◽  
Vol 6 ◽  
pp. 247275122110308
Author(s):  
Charudatta Naik ◽  
Sanjay Joshi ◽  
Bhupendra Mhatre ◽  
Sneha Punamiya
Keyword(s):  
Parotid Gland ◽  
Basal Cell ◽  
Benign Tumor ◽  
Transoral Approach ◽  
Surgical Approaches ◽  
Basal Cell Adenoma ◽  
Diagnostic Dilemma ◽  
Cell Adenoma ◽  
Rare Benign Tumor ◽  
Accessory Parotid Gland

Diagnosis of mid-cheek mass has always been a diagnostic dilemma for clinicians. The incidence of the accessory parotid gland (APG) has been well documented in the literature. However, a diverse spectrum of pathologies can arise from this accessory parotid tissue. Basal cell adenoma is a rare benign tumor that predominantly affects the parotid gland. Its occurrence in the accessory parotid gland has been documented in 9 cases till date. Surgical approaches for the management of such APG lesions have been in debate. This report documents a case of Basal Cell Adenoma arising in accessory parotid tissue in a 55-year-old woman who was treated by transoral excision. This paper also reviews previously documented cases of all APG lesions and attempts to elucidate the rationale for selecting an appropriate surgical approach.

Trabecular and solid-cribriform types of basal cell adenoma

1992 ◽  
Vol 73 (1) ◽  
pp. 75-83 ◽  
Author(s):  
Irving Dardick ◽  
Alice Lytwyn ◽  
Anthony J. Bourne ◽  
Roger W. Byard
Keyword(s):  
Basal Cell ◽  
Basal Cell Adenoma ◽  
Cell Adenoma

scholarly journals Tubular Type of Basal Cell Adenoma of Parotid Gland: A Rare Entity

2015 ◽  
Vol 5 (3) ◽  
pp. 184-187
Author(s):  
Pratik Dipak Shah ◽  
Srijon Mukherji
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Basal Cell ◽  
Myoepithelial Cell ◽  
Rare Case ◽  
Salivary Gland Neoplasm ◽  
Rare Entity ◽  
Basal Cell Adenoma ◽  
Cell Adenoma ◽  
Tubular Type

ABSTRACT Basal cell adenoma (BCA) is a significantly rare benign salivary gland neoplasm that includes isomorphic basaloid cells. Presence of myoepithelial cell is a characteristic of this tumor. Basal cell adenoma accounts for only 1 to 2% of all salivary gland epithelial tumors. The goal of the paper is to report a rare case of tubular type of BCA arising from parotid gland and discuss its management. How to cite this article Shah PD, Mukherji S. Tubular Type of Basal Cell Adenoma of Parotid Gland: A Rare Entity. J Contemp Dent 2015;5(3):184-187.

scholarly journals A case of basal cell adenoma in the parotid gland

2005 ◽  
Vol 51 (7) ◽  
pp. 352-355
Author(s):  
Hiroko SHIDA ◽  
Akio TANAKA ◽  
Masakatsu FUKUDA ◽  
Hisao SHIGEMATSU ◽  
Kaoru KUSAMA ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Basal Cell ◽  
Basal Cell Adenoma ◽  
Cell Adenoma
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