Role of cytology and immunochemistry in diagnosis of metastatic malignancies in the lung: A critical appraisal

2018 ◽  
Vol 46 (11) ◽  
pp. 936-944
Author(s):  
Varsha Manucha ◽  
Jeffery T. Hansen ◽  
Maria F. Gonzalez ◽  
Israh Akhtar
Keyword(s):  
Critical Appraisal

935: Critical Appraisal of the Role of Ureteroscopy in Treatment of Pediatric Renal and Ureteric Calculi

2007 ◽  
Vol 177 (4S) ◽  
pp. 310-310
Author(s):  
Sumit Dave ◽  
Luis H. Braga ◽  
Antoine E. Khoury ◽  
Walid A. Farhat
Keyword(s):  
Critical Appraisal ◽  
Ureteric Calculi

scholarly journals Understanding the nature and scope of clinical research commentaries in PubMed

2019 ◽  
Vol 27 (3) ◽  
pp. 449-456
Author(s):  
James R Rogers ◽  
Hollis Mills ◽  
Lisa V Grossman ◽  
Andrew Goldstein ◽  
Chunhua Weng
Keyword(s):  
Clinical Research ◽  
Sentiment Analysis ◽  
Random Sample ◽  
Full Text ◽  
Topic Modeling ◽  
Critical Appraisal ◽  
Research Articles ◽  
Disease Specific ◽  
Research Studies

Abstract Scientific commentaries are expected to play an important role in evidence appraisal, but it is unknown whether this expectation has been fulfilled. This study aims to better understand the role of scientific commentary in evidence appraisal. We queried PubMed for all clinical research articles with accompanying comments and extracted corresponding metadata. Five percent of clinical research studies (N = 130 629) received postpublication comments (N = 171 556), resulting in 178 882 comment–article pairings, with 90% published in the same journal. We obtained 5197 full-text comments for topic modeling and exploratory sentiment analysis. Topics were generally disease specific with only a few topics relevant to the appraisal of studies, which were highly prevalent in letters. Of a random sample of 518 full-text comments, 67% had a supportive tone. Based on our results, published commentary, with the exception of letters, most often highlight or endorse previous publications rather than serve as a prominent mechanism for critical appraisal.

A critical appraisal of the role of respiratory supercomplexes in mitochondria

2013 ◽  
Vol 394 (5) ◽  
pp. 631-639 ◽  
Author(s):  
Maria Luisa Genova ◽  
Giorgio Lenaz
Keyword(s):  
Critical Appraisal ◽  
Dynamic Equilibrium ◽  
Coenzyme Q ◽  
Mitochondrial Respiratory Chain ◽  
Substantial Evidence ◽  
Mammalian Mitochondria ◽  
Respiratory Supercomplexes ◽  
Functional Relevance ◽  
The Individual

Abstract Substantial evidence exists that the mitochondrial respiratory chain is organized in supramolecular units called supercomplexes or respirasomes. While the structural evidence of the supercomplexes is overwhelming, fewer studies have focused on their functional relevance. Although the presence of coenzyme Q channeling between complexes I and III has been ascertained, no such clear demonstration has been carried out for cytochrome c between complexes III and IV, at least in mammalian mitochondria. This review also discusses the implications concerning the number of respiratory complexes organized in supercomplexes and the possibility that they represent associations in dynamic equilibrium with the individual complexes.

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