Use of fine-needle aspirate calcitonin to detect medullary thyroid carcinoma: A systematic review

2015 ◽  
Vol 44 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Pierpaolo Trimboli ◽  
Leo Guidobaldi ◽  
Massimo Bongiovanni ◽  
Anna Crescenzi ◽  
Maria Alevizaki ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Fine Needle Aspirate ◽  
Medullary Thyroid ◽  
Fine Needle

scholarly journals Calcitonin in fine-needle aspirate washout fluid and serum for the differential diagnosis of Medullary Thyroid Carcinomain patients with thyroid nodules

2020 ◽  
Author(s):  
Xianming Liang ◽  
Ende Lin ◽  
Zhang Dai ◽  
Jianhui Zhu ◽  
Minjing Cai ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Fine Needle Aspirate ◽  
Characteristic Analysis ◽  
Cutoff Value ◽  
Medullary Thyroid ◽  
Fine Needle ◽  
Median Concentration

Abstract Purpose To assess a cutoff value and the diagnosis performance of CT in fine-needle aspirate washout fluid (FNA-CT) and serum in consecutive patients with thyroid nodules by chemiluminescence immunoassay method (CLIA).Methods 1,941 healthy persons, 212 patients with 235 thyroid nodules were investigated. They were classified into were classified into healthy, nodular goiter, chronic thyroiditis, thyroid follicular neoplasm, papillary thyroid carcinoma, follicular thyroid carcinoma and medullary thyroid carcinoma. Serum CT and FNA-CT were measured by CLIA.Results Serum CT median concentration in MTC was 301.0 pg/mL, significantly higher than other groups. The cutoff value of serum CT was 13.8 pg/mL, leading 100.00% sensitivity, 97.99% specificity and 0.86 Kappa value in MTC. The FNA-CT median concentration in MTC nodules was 5000.0 pg/mL, significantly higher than other groups. A receiver operating characteristic analysis of MTC nodules and non-MTC nodules indicated that the cutoff value was 91.6pg/mL, leading to 100.00% sensitivity, 97.25% specificity and 0.84 Kappa value.Conclusion FNA-CT and serum were perfect marker for the differential diagnosis of medullary thyroid carcinoma in patients with thyroid nodules. The optimal cutoff values with CLIA were 13.8 pg/mL and 91.6pg/mL, respectively.

ProGRP AS A NOVEL BIOMARKER FOR THE DIFFERENTIAL DIAGNOSIS OF MEDULLARY THYROID CARCINOMA IN PATIENTS WITH THYROID NODULES

2020 ◽  
Vol 26 (5) ◽  
pp. 514-522
Author(s):  
Xianming Liang ◽  
Jianhui Zhu ◽  
Minjing Cai ◽  
Zhang Dai ◽  
Lili Fang ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Fine Needle Aspirate ◽  
Cutoff Value ◽  
Medullary Thyroid ◽  
Fine Needle ◽  
Median Concentration ◽  
Kappa Value

Objective: To investigate the release of progastrin-releasing peptide (ProGRP) in patients with thyroid nodules and the value of ProGRP in fine-needle aspirate washout fluid (FNA-ProGRP) in the differential diagnosis between medullary thyroid carcinoma (MTC) and non-MTC thyroid nodules. Methods: We investigated 2,446 healthy persons and 212 patients with 235 thyroid nodules. They were classified into healthy, nodular goiter, chronic thyroiditis, thyroid follicular neoplasm, papillary thyroid carcinoma, follicular thyroid carcinoma, and medullary thyroid carcinoma. The serum ProGRP and FNA-ProGRP were measured. Results: The serum ProGRP median concentration in MTC was 124.40 pg/mL, significantly higher than in other groups. The cutoff value of serum ProGRP was 68.30 pg/mL, leading to 53.85% sensitivity, 96.98% specificity, and 0.51 kappa value in MTC. The FNA-ProGRP median concentration in MTC nodules was 2,096.00 pg/mL, significantly higher than in other groups. A receiver operating characteristic analysis of MTC nodules and non-MTC nodules indicated that the cutoff value was 22.77 pg/mL, leading to 94.12% sensitivity, 98.27% specificity, and 0.85 kappa value. Conclusion: FNA-ProGRP measurement could be served as an ancillary method for the differential diagnosis between MTC and non-MTC thyroid nodules. Abbreviations: CEA = carcinoembryonic antigen; CT = calcitonin; FNAC = fine-needle aspiration cytology; FNA-CT = calcitonin in fine-needle aspirate washout fluid; FNA-ProGRP = ProGRP in fine-needle aspirate washout fluid; MTC = medullary thyroid carcinoma; ProGRP = progastrin-releasing peptide; SCLC = small-cell lung cancer; TM = tumor marker

scholarly journals Procalcitonin for detecting medullary thyroid carcinoma: a systematic review

2015 ◽  
Vol 22 (3) ◽  
pp. R157-R164 ◽  
Author(s):  
Pierpaolo Trimboli ◽  
Ettore Seregni ◽  
Giorgio Treglia ◽  
Maria Alevizaki ◽  
Luca Giovanella
Keyword(s):  
Systematic Review ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Search Algorithm ◽  
Serum Marker ◽  
Medullary Thyroid ◽  
Previously Treated ◽  
Patient Series ◽  
Cutoff Levels

The aim of the present study was to perform a systematic review of published studies to provide a robust estimation of the use of procalcitonin (ProCT) as a diagnostic marker of medullary thyroid carcinoma (MTC), with particular focus on its specificity and negative predictive value in excluding MTC. A comprehensive computer literature search was conducted to find relevant published articles on the topic. We used a search algorithm based on a combination of the terms ‘medullary,’ ‘thyroid,’ and ‘ProCT.’ The search was updated until February 2015. To expand our search, references of the retrieved articles were also screened. A total of 39 articles were retrieved, of which nine original papers published from 2003 to 2014 were selected for the review. Some of these studies used ProCT in the preoperative diagnosis of MTC, whereas others measured ProCT during the follow-up of patients who had been previously treated for MTC. Other laboratory measurements were performed in some of the included studies. The results of the majority of the studies indicate that ProCT measurement appears to be a very promising and reliable serum marker for the diagnosis of MTC, and it is not inferior to calcitonin (CT). The sample handling is less laborious, and in the few CT-negative cases reviewed, the assay had even greater sensitivity. It would be worthwhile to establish cutoff levels using larger patient series, because we speculate that this assay could potentially replace CT measurement in the future.

Oncocytic variant of medullary thyroid carcinoma; a rare tumor with numerous diagnostic mimics by fine needle aspiration

2017 ◽  
Vol 45 (12) ◽  
pp. 1148-1152 ◽  
Author(s):  
Sharon B. Sams ◽  
Kenneth D. Tompkins ◽  
Sarah Mayson ◽  
Christopher D. Raeburn ◽  
Sanjana Mehrotra
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Rare Tumor ◽  
Medullary Thyroid ◽  
Fine Needle ◽  
Oncocytic Variant

Diagnosis of pseudopapillary variant of medullary thyroid carcinoma by fine-needle aspiration cytology

2013 ◽  
Vol 42 (9) ◽  
pp. 823-826 ◽  
Author(s):  
Namiki Kawanishi ◽  
Yoshiaki Norimatsu ◽  
Hiroyuki Ohsaki ◽  
Tsutomu Yuminamochi ◽  
Ryohei Katoh ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Medullary Thyroid ◽  
Fine Needle ◽  
Needle Aspiration Cytology

scholarly journals Diagnostic Pitfall of Thyroid Fine-needle Aspiration Induced Fibrosis: Follicular Adenoma Mimicking Medullary Thyroid Carcinoma in Frozen Section

2020 ◽  
Author(s):  
Woo Sung Moon ◽  
Myoung Jae Kang ◽  
Hyun Jo Youn ◽  
Kyoung Min Kim
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Fine Needle Aspiration ◽  
Frozen Section ◽  
Follicular Adenoma ◽  
Needle Aspiration ◽  
Medullary Thyroid ◽  
Fine Needle ◽  
Histological Alterations ◽  
Diagnostic Pitfall

Abstract Background:Fine-needle aspiration (FNA) is a frequently utilized method for the diagnosis of thyroid nodules. Although the technique has clear advantages, the injury caused by the aspiration needle can induce various histological alterations. Herein, we report a case of follicular adenoma showing histological alterations possibly caused by FNA biopsy. Furthermore, the histological appearance of the lesion mimicked those of medullary thyroid carcinoma, particularly in the frozen section. Case presentation: Ultrasonography of a thyroid nodule in a 39-year-old man revealed a mass (2.2cm in diameter) in the right thyroid lobe. FNA was performed three times on the mass, and the results of the cytology were atypia of undetermined significance. Thereafter, the patient underwent right hemithyroidectomy. The histological findings of the operative frozen section analysis indicated medullary thyroid carcinoma. However, after evaluation and immunohistochemical staining of the permanent section, the mass was diagnosed as follicular adenoma with extensive fibrosis.Conclusion:The histological alterations observed in the follicular adenoma are believed to have been caused by injury during the repeated FNA procedures.

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