Acute promyelocytic leukemia-associated Sweet's syndrome mimicking an axillary abscess: A case report with review of literature

2015 ◽  
Vol 43 (12) ◽  
pp. 1007-1010 ◽  
Author(s):  
Vandana L. Gaopande ◽  
Sourabh S. Joshi ◽  
Avinash R. Joshi
Keyword(s):  
Case Report ◽  
Acute Promyelocytic Leukemia ◽  
Promyelocytic Leukemia ◽  
Sweet’S Syndrome ◽  
Review Of Literature ◽  
Sweet's Syndrome

Sweet's Syndrome During Treatment with All-Trans Retinoic Acid in a Patient with Acute Promyelocytic Leukemia

1998 ◽  
Vol 31 (5-6) ◽  
pp. 613-615 ◽  
Author(s):  
Banu Arun ◽  
Brenda Berberian ◽  
Norio Azumic ◽  
Stanley R Frankela ◽  
Harvey Luksenburga ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Acute Promyelocytic Leukemia ◽  
Promyelocytic Leukemia ◽  
Sweet’S Syndrome ◽  
Sweet's Syndrome ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals Distinct Characteristics of Sweet’s Syndrome of the Scrotum Caused by All-trans Retinoic Acid in a Patient with Acute Promyelocytic Leukemia

2021 ◽  
pp. 1466-1474
Author(s):  
Osamu Imataki ◽  
Shunsuke Yoshida ◽  
Tomohiro Kaji ◽  
Jun-ichiro Kida ◽  
Hiroyuki Kubo ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Acute Promyelocytic Leukemia ◽  
Induction Chemotherapy ◽  
Clinical Manifestations ◽  
Promyelocytic Leukemia ◽  
Skin Ulcer ◽  
Neutrophilic Dermatosis ◽  
Sweet’S Syndrome ◽  
Scrotal Skin ◽  
Sweet's Syndrome

Induction therapy with all-<i>trans</i> retinoic acid (ATRA) is effective for acute promyelocytic leukemia (APL). ATRA induces neutrophil differentiation and its associated side effects. The differentiation syndrome is the most characterized ATRA-induced adverse effect. Sweet’s syndrome, also known as neutrophilic dermatosis, is another form of ATRA-associated disease characterized by neutrophil infiltrating erythema that develops with fever. This is a case of a 34-year-old Japanese man diagnosed with APL. At the onset, the patient did not have skin involvement of APL cells. He was treated with ATRA and induction chemotherapy with idarubicin and cytarabine. Scrotal skin rash occurred at day 14, which developed into scrotal ulceration up to day 28 even after eliminating APL cells in his peripheral blood. Sweet’s syndrome is a pathological diagnosis of scrotal skin ulceration representing neutrophil infiltration. The infiltrating neutrophils showed PML-RARα rearrangement. The patient was diagnosed with ATRA-associated Sweet’s syndrome with skin ulcer. His cutaneous lesion did not respond to intravenous prednisolone therapy; thereby, ATRA was discontinued. After the cessation of ATRA, the skin lesion improved in the next week. We confirmed he achieved a complete response after induction chemotherapy. In our observation, ATRA-associated Sweet’s syndrome is characterized by the following clinical manifestations: preferable occurrence in the scrota, tend to progress into skin ulcer, and pathogenicity associated with PML-RARα-positive matured neutrophils. The etiology, pathogenesis, and risk factors of ATRA-associated scrotal ulceration were discussed in the literature review.

scholarly journals Acute promyelocytic leukemia presenting as recurrent spinal myeloid sarcomas 3 years before developing leukemia: A case report with review of literature

2019 ◽  
Vol 7 (2) ◽  
pp. 316-321 ◽  
Author(s):  
Tomoko Yamashita ◽  
Akihiko Nishijima ◽  
Yuma Noguchi ◽  
Kensuke Narukawa ◽  
Gaku Oshikawa ◽  
...  
Keyword(s):  
Case Report ◽  
Acute Promyelocytic Leukemia ◽  
Promyelocytic Leukemia ◽  
Review Of Literature
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